BAKER BROS. ADVISORS LP Q3 2020 Filing

Filed November 16, 2020

Portfolio Value

$25.0B

Holdings

120

Report Date

Q3 2020

Filing Type

13F-HR

All Holdings (120 positions)

#StockSharesValue% PortfolioType
1
SGENUSDSeagen Inc.
47,269,424$9.3T36962.28%
2
ONCBeiGene, Ltd.
13,301,597$3.8T15224.65%
3
INCYIncyte Corporation
31,999,398$2.9T11474.60%
4
ACADACADIA Pharmaceuticals Inc.
41,904,586$1.7T6907.09%
5
ALXNAlexion Pharmaceuticals, Inc.
8,760,794$1.0T4005.84%
6
KODKodiak Sciences Inc.
12,352,175$731.4B2922.46%
7
BMRNBioMarin Pharmaceutical Inc.
7,589,294$577.4B2307.18%
8
ASNDAscendis Pharma A/S
3,540,270$546.3B2183.07%
9
NVTA1EURInvitae Corporation
11,850,962$513.7B2052.83%
10
MyoKardia, Inc.
3,009,344$410.3B1639.36%
11
PRLDPrelude Therapeutics Incorporated
10,118,636$304.9B1218.24%
12
ARGXargenx SE
1,019,557$267.7B1069.51%
13
MRTXEURMirati Therapeutics, Inc.
1,409,784$234.1B935.41%
14
1K0IGM Biosciences, Inc.
3,144,446$232.1B927.41%
15
EXASExact Sciences Corporation
1,846,139$188.2B752.08%
16
MDGLMadrigal Pharmaceuticals, Inc.
1,499,213$178.0B711.27%
17
AMRNAmarin Corporation plc
32,018,867$134.8B538.64%
18
HRTXHeron Therapeutics, Inc.
5,994,704$88.8B355.00%
19
Forma Therapeutics Holdings, Inc.
1,771,509$88.3B352.80%
20
CERSCerus Corporation
13,713,195$85.8B343.02%
21
Zymeworks Inc.
1,708,472$79.6B317.99%
22
IM8NInsmed Incorporated
2,272,712$73.0B291.88%
23
AXSMAxsome Therapeutics, Inc.
959,757$68.4B273.25%
24
NBIXNeurocrine Biosciences, Inc.
676,975$65.1B260.12%
25
KYMRKymera Therapeutics, Inc.
1,959,211$63.3B252.95%
26
NRIXNurix Therapeutics, Inc.
1,788,921$62.5B249.55%
27
ALLKGUSDAllakos Inc.
698,469$56.9B227.32%
28
ADCTADC Therapeutics SA
1,687,500$55.7B222.45%
29
RYTMRhythm Pharmaceuticals, Inc.
2,471,155$53.5B213.98%
30
HZNPHorizon Therapeutics Public Ltd Co
666,500$51.8B206.88%
31
GBTUSDGlobal Blood Therapeutics, Inc.
920,375$50.7B202.79%
32
ADAPYAdaptimmune Therapeutics plc
6,330,354$50.5B201.85%
33
BCELAtreca, Inc.
3,532,760$49.4B197.21%
34
CCXIEURChemoCentryx, Inc.
899,821$49.3B197.04%
35
Neoleukin Therapeutics, Inc.
3,821,740$45.9B183.25%
36
BCRXBioCryst Pharmaceuticals, Inc.
12,695,818$43.6B174.26%
37
KNSAKiniksa Pharmaceuticals, Ltd.
2,799,577$42.9B171.38%
38
NBIX 2.25 05/15/24Neurocrine Biosciences, Inc.
30,770,000$42.3B169.19%
39
KRYSKrystal Biotech, Inc.
775,192$33.4B133.35%
40
PACBPacific Biosciences of California, Inc.
3,250,000$32.1B128.18%
41
PTGXProtagonist Therapeutics, Inc.
1,596,198$31.2B124.69%
42
AGLEUSDAeglea BioTherapeutics, Inc.
4,379,592$31.1B124.08%
43
ALTAltimmune, Inc.
2,206,955$29.1B116.41%
44
APLSApellis Pharmaceuticals, Inc.
896,551$27.0B108.08%
45
ASMBAssembly Biosciences, Inc.
1,541,418$25.3B101.26%
46
DBV Technologies S.A.
14,614,264$25.3B101.03%
47
MRUSMerus N.V.
2,037,469$24.4B97.70%
48
AUPHAurinia Pharmaceuticals Inc.
1,618,029$23.8B95.24%
49
CBAYUSDCymabay Therapeutics, Inc.
3,252,542$23.5B94.09%
50
ALKSAlkermes plc
1,359,001$22.5B89.98%
51
FLGTFulgent Genetics, Inc.
546,189$21.9B87.39%
52
ADPTAdaptive Biotechnologies Corporation
440,539$21.4B85.60%
53
NVV1Novavax, Inc.
187,376$20.3B81.12%
54
Immunomedics, Inc.
237,694$20.2B80.76%
55
BDQMAlbireo Pharma, Inc.
549,047$18.3B73.21%
56
Frequency Therapeutics, Inc.
949,555$18.2B72.89%
57
Invitae Corporation
10,300,000$16.9B67.55%
58
Athira Pharma, Inc.
882,352$16.3B65.08%
59
XNCRXencor, Inc.
410,142$15.9B63.57%
60
BMRN 0.599 08/01/24BioMarin Pharmaceutical Inc.
15,000,000$15.7B62.54%
61
bluebird bio, Inc.
252,000$13.6B54.32%
62
HRMYHarmony Biosciences Holdings, Inc.
400,000$13.6B54.18%
63
GW Pharmaceuticals plc
138,745$13.5B53.97%
64
MIRMMirum Pharmaceuticals, Inc.
553,009$10.7B42.58%
65
IMTXImmatics N.V.
1,001,414$10.6B42.46%
66
VXRTVaxart, Inc.
1,566,121$10.4B41.62%
67
Idera Pharmaceuticals, Inc.
4,608,786$9.9B39.41%
68
Urovant Sciences Ltd.
978,505$9.1B36.52%
69
GBYSangamo Therapeutics, Inc.
949,823$9.0B35.87%
70
XENEXenon Pharmaceuticals Inc.
760,308$8.4B33.63%
71
OPHTEURIVERIC bio, Inc.
1,406,037$7.9B31.69%
72
ANABAnaptysBio, Inc.
487,243$7.2B28.72%
73
QUREuniQure N.V.
194,383$7.2B28.61%
74
CABACabaletta Bio, Inc.
636,363$6.9B27.56%
75
HOOKGBPHOOKIPA Pharma Inc.
700,481$6.6B26.51%
76
Syros Pharmaceuticals, Inc.
690,167$6.1B24.38%
77
KRTXKaruna Therapeutics, Inc.
77,776$6.0B24.03%
78
BNRBurning Rock Biotech Limited
237,300$6.0B23.78%
79
AUTLAutolus Therapeutics plc
461,324$5.4B21.46%
80
RETAEURReata Pharmaceuticals, Inc.
53,183$5.2B20.70%
81
REPLReplimune Group, Inc.
206,586$4.8B19.00%
82
CRNXCrinetics Pharmaceuticals, Inc.
302,320$4.7B18.93%
83
IFRXInflarx N.V.
1,007,559$4.3B17.15%
84
5E7Iteos Therapeutics, Inc.
167,562$4.1B16.52%
85
AKROAkero Therapeutics, Inc.
131,788$4.1B16.22%
86
LEGNLegend Biotech Corporation
128,200$4.0B15.82%
87
DNLIDenali Therapeutics Inc.
99,400$3.6B14.23%
88
PASGPassage Bio, Inc.
261,066$3.4B13.68%
89
OVIDOvid Therapeutics Inc.
590,761$3.4B13.55%
90
TARAProtara Therapeutics, Inc.
199,671$3.4B13.43%
91
Chiasma, Inc.
742,133$3.2B12.75%
92
INZYInozyme Pharma, Inc.
118,500$3.1B12.45%
93
XLRNAcceleron Pharma Inc.
25,640$2.9B11.53%
94
ALECAlector, Inc.
265,600$2.8B11.18%
95
KZRKezar Life Sciences, Inc.
574,958$2.8B11.12%
96
Constellation Pharmaceuticals, Inc.
133,333$2.7B10.79%
97
Gamida Cell Ltd.
633,324$2.6B10.50%
98
TCR2 Therapeutics Inc.
122,532$2.5B9.95%
99
NTLAIntellia Therapeutics, Inc.
122,238$2.4B9.71%
100
VKTXViking Therapeutics, Inc.
404,200$2.4B9.40%
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