Rock Springs Capital Management LP
CIK: 0001595725Latest portfolio: $2.0B · Q4 2025
Holdings
98
Total Value
$2.0B
New Positions
17
Closed Positions
12
Top Holdings
View All 98 Holdings →| # | Stock | Shares | Value | % Portfolio | Change | Type |
|---|---|---|---|---|---|---|
| 1 | LLYELI LILLY & CO | 105,400 | $113.3M | 5.81% | — | |
| 2 | RVMDREVOLUTION MEDICINES INC | 1,335,270 | $106.4M | 5.45% | — | |
| 3 | ARGXARGENX SE | 103,250 | $86.8M | 4.45% | -39,500 | |
| 4 | TVTXTRAVERE THERAPEUTICS INC | 2,210,322 | $84.5M | 4.33% | +46K | |
| 5 | MDGLMADRIGAL PHARMACEUTICALS INC | 139,618 | $81.3M | 4.17% | +2K | |
| 6 | RYTMRHYTHM PHARMACEUTICALS INC | 695,010 | $74.4M | 3.81% | -22,092 | |
| 7 | EXASEXACT SCIENCES CORP | 601,800 | $61.1M | 3.13% | +8K | |
| 8 | MIRMMIRUM PHARMACEUTICALS INC | 762,294 | $60.2M | 3.09% | +1K | |
| 9 | IM8NINSMED INC | 319,250 | $55.6M | 2.85% | -65,750 | |
| 10 | GPCRSTRUCTURE THERAPEUTICS INC | 748,236 | $52.0M | 2.67% | -202,918 | |
| 11 | ISRGINTUITIVE SURGICAL INC | 82,000 | $46.4M | 2.38% | — | |
| 12 | CDTXCIDARA THERAPEUTICS INC | 204,878 | $45.3M | 2.32% | -44,524 | |
| 13 | ASNDASCENDIS PHARMA A/S | 203,500 | $43.4M | 2.23% | -11,000 | |
| 14 | IRTCIRHYTHM TECHNOLOGIES INC | 235,000 | $41.7M | 2.14% | — | |
| 15 | KYMRKYMERA THERAPEUTICS INC | 496,871 | $38.7M | 1.98% | +46K | |
| 16 | BSXBOSTON SCIENTIFIC CORP | 399,050 | $38.0M | 1.95% | +39K | |
| 17 | PENPENUMBRA INC | 120,500 | $37.5M | 1.92% | — | |
| 18 | XENEXENON PHARMACEUTICALS INC | 787,788 | $35.3M | 1.81% | -63,956 | |
| 19 | SRRKSCHOLAR ROCK HLDG CORP | 733,477 | $32.3M | 1.66% | -60,656 | |
| 20 | COGTCOGENT BIOSCIENCES INC | 849,030 | $30.2M | 1.55% | -159,278 | |
| 21 | RAREULTRAGENYX PHARMACEUTICAL IN | 1,267,241 | $29.1M | 1.49% | +21K | |
| 22 | VERAVERA THERAPEUTICS INC | 568,579 | $28.8M | 1.48% | -48,817 | |
| 23 | ALNYALNYLAM PHARMACEUTICALS INC | 71,250 | $28.3M | 1.45% | -3,000 | |
| 24 | AM6AMICUS THERAPEUTICS INC | 1,929,931 | $27.5M | 1.41% | -17,443 | |
| 25 | XBISPDR SERIES TRUST | 222,000 | $27.1M | 1.39% | +70K |
Quarterly Changes
New Positions
Increased Positions
Sector Breakdown
HealthcareNaN% ($InfinityT)
Unknown0.0% ($5.556245255274823e+33T)
Financial Services0.0% ($270.7B)
Filing History
| Quarter | Filing Date | Portfolio Value | Holdings |
|---|---|---|---|
| Q4 2025 | Feb 17, 2026 | $2.0B | 99 |
| Q3 2025 | Nov 14, 2025 | $1.7T | 93 |
| Q2 2025 | Aug 14, 2025 | $1.6T | 93 |
| Q1 2025 | May 15, 2025 | $1.7T | 96 |
| Q4 2024 | Feb 14, 2025 | $2.6T | 107 |
| Q3 2024 | Nov 14, 2024 | $3073.7T | 109 |
| Q2 2024 | Aug 14, 2024 | $3322.4T | 112 |
| Q1 2024 | May 15, 2024 | $3938.8T | 114 |
| Q4 2023 | Feb 14, 2024 | $4062.2T | 104 |
| Q3 2023 | Nov 14, 2023 | $3733.2T | 120 |
| Q2 2023 | Aug 14, 2023 | $4203.2T | 123 |
| Q1 2023 | May 15, 2023 | $4191.3T | 121 |
| Q4 2022 | Feb 14, 2023 | $4155.9T | 120 |
| Q3 2022 | Nov 14, 2022 | $3.9T | 128 |
| Q2 2022 | Aug 15, 2022 | $3.4T | 131 |
| Q1 2022 | May 16, 2022 | $4.0T | 135 |
| Q4 2021 | Feb 14, 2022 | $4.3T | 136 |
| Q3 2021 | Nov 15, 2021 | $4.8T | 153 |
| Q2 2021 | Aug 16, 2021 | $5.1T | 156 |
| Q1 2021 | May 17, 2021 | $4.6T | 151 |
| Q4 2020 | Feb 16, 2021 | $4.7T | 155 |
| Q3 2020 | Nov 16, 2020 | $3.9T | 148 |
| Q2 2020 | Aug 14, 2020 | $3.6T | 143 |
| Q1 2020 | May 15, 2020 | $2.4T | 131 |
| Q4 2019 | Feb 14, 2020 | $3.2T | 130 |
| Q3 2019 | Nov 14, 2019 | $2.5T | 138 |
| Q2 2019 | Aug 14, 2019 | $2.8T | 135 |
| Q1 2019 | May 15, 2019 | $2.6T | 131 |
| Q4 2018 | Feb 14, 2019 | $2.1T | 133 |
| Q3 2018 | Nov 14, 2018 | $2.8T | 144 |
| Q2 2018 | Aug 14, 2018 | $2.6T | 147 |
| Q1 2018 | May 15, 2018 | $2.3T | 149 |
| Q4 2017 | Feb 14, 2018 | $2.2T | 145 |
| Q3 2017 | Nov 14, 2017 | $2.2T | 147 |
| Q2 2017 | Aug 14, 2017 | $2.0T | 149 |
| Q1 2017 | May 15, 2017 | $1.7T | 140 |
| Q4 2016 | Feb 14, 2017 | $1.5T | 133 |
| Q3 2016 | Nov 14, 2016 | $1.6T | 137 |
| Q2 2016 | Aug 15, 2016 | $1.4T | 137 |
| Q1 2016 | May 16, 2016 | $1.2T | 128 |
Fund Information
Rock Springs Capital Management LP is an institutional investment manager that files 13F reports with the SEC. As of the Q4 2025 filing, the fund reported a portfolio valued at $2.0B across 98 holdings. The largest position is ELI LILLY & CO (LLY), representing 5.8% of the portfolio. Compared to the previous quarter, the fund opened 18 new positions and closed 12 positions. 13F filings are required quarterly disclosures that provide transparency into the holdings of institutional investment managers with at least $100 million in qualifying assets.