| 1 | Opaleye Management Inc. | 2,070,784 | $13.5M | 1.78% | Share |
| 2 | Solas Capital Management, LLC | 1,968,052 | $12.8M | 7.26% | Share |
| 3 | AWM Investment Company, Inc. | 1,672,168 | $10.9M | 1.05% | Share |
| 4 | Cable Car Capital, LP | 1,060,212 | $6.9M | 0.23% | Share |
| 5 | Ikarian Capital, LLC | 1,056,259 | $6.9M | 0.54% | Share |
| 6 | SPHERA FUNDS MANAGEMENT LTD. | 567,616 | $3.7M | 0.71% | Share |
| 7 | Alyeska Investment Group, L.P. | 365,000 | $2.0M | 0.01% | Share |
| 8 | CANTOR FITZGERALD, L. P. | 163,431 | $1.1M | 0.02% | Share |
| 9 | Aristides Capital LLC | 215,458 | $1.0M | 0.18% | Share |
| 10 | BOOTHBAY FUND MANAGEMENT, LLC | 256,393 | $1.0M | 0.01% | Share |
| 11 | VILLERE ST DENIS J & CO LLC | 73,875 | $480K | 0.05% | Share |
| 12 | ACT CAPITAL MANAGEMENT, LLC | 51,500 | $334K | 0.27% | Share |
| 13 | BERKSHIRE ASSET MANAGEMENT LLC/PA | 19,824 | $128K | 0.01% | Share |
| 14 | Green Alpha Advisors, LLC | 11,126 | $72K | 0.07% | Share |
| 15 | UBS Group AG | 927 | $6K | 0.00% | Share |
| 16 | Allworth Financial LP | 750 | $4K | 0.00% | Share |
| 17 | PNC FINANCIAL SERVICES GROUP, INC. | 120 | $0 | 0.00% | Share |
| 18 | NATIONAL BANK OF CANADA /FI/ | 5,292 | $0 | 0.00% | Share |
| 19 | TUDOR INVESTMENT CORP ET AL | 61,596 | $0 | 0.00% | Share |
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,706 | $0 | 0.00% | Share |
| 21 | CITADEL ADVISORS LLC | 118,421 | $0 | 0.00% | Share |
| 22 | TWO SIGMA INVESTMENTS, LP | 57,572 | $0 | 0.00% | Share |
| 23 | ROYAL BANK OF CANADA | 122 | $0 | 0.00% | Share |
| 24 | MARSHALL WACE, LLP | 46,831 | $0 | 0.00% | Share |
| 25 | MARSHALL WACE, LLP | 6,372 | $0 | 0.00% | Share |
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 11,992 | $0 | 0.00% | Share |
| 27 | Quadrature Capital Ltd | 12,501 | $0 | 0.00% | Share |
| 28 | Steward Partners Investment Advisory, LLC | 200 | $0 | 0.00% | Share |