| 1 | FARALLON CAPITAL MANAGEMENT LLC | 5,159,505 | $140.4M | 0.66% | Share |
| 2 | VANGUARD GROUP INC | 5,136,492 | $139.8M | 0.00% | Share |
| 3 | STATE STREET CORP | 3,108,145 | $84.0M | 0.00% | Share |
| 4 | ARMISTICE CAPITAL, LLC | 3,036,000 | $82.6M | 0.98% | Share |
| 5 | ARMISTICE CAPITAL, LLC | 3,000,000 | $81.7M | 0.97% | Call |
| 6 | Erste Asset Management GmbH | 2,804,900 | $76.0M | 0.64% | Share |
| 7 | BlackRock, Inc. | 2,464,200 | $67.0M | 0.00% | Share |
| 8 | NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 1,701,409 | $46.0M | 0.07% | Share |
| 9 | BlackRock, Inc. | 1,670,066 | $45.0M | 0.00% | Share |
| 10 | D. E. Shaw & Co., Inc. | 1,352,662 | $36.0M | 0.02% | Share |
| 11 | MPM BioImpact LLC | 1,303,373 | $35.5M | 4.06% | Share |
| 12 | Frazier Life Sciences Management, L.P. | 1,279,754 | $34.8M | 0.94% | Share |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 1,225,114 | $33.0M | 0.00% | Share |
| 14 | TCG Crossover Management, LLC | 1,181,841 | $32.2M | 1.06% | Share |
| 15 | BNP Paribas Asset Management Holding S.A. | 1,181,000 | $32.0M | 0.04% | Share |
| 16 | GW&K Investment Management, LLC | 1,155,757 | $31.5M | 0.27% | Share |
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,142,432 | $31.0M | 0.00% | Share |
| 18 | CITADEL ADVISORS LLC | 1,052,743 | $28.0M | 0.00% | Share |
| 19 | GOLDMAN SACHS GROUP INC | 931,169 | $25.0M | 0.00% | Share |
| 20 | DIMENSIONAL FUND ADVISORS LP | 950,221 | $25.0M | 0.01% | Share |
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 903,900 | $24.0M | 0.00% | Put |
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 836,000 | $22.0M | 0.00% | Call |
| 23 | Rock Springs Capital Management LP | 799,163 | $21.8M | 1.12% | Share |
| 24 | Capital International Investors | 703,865 | $19.0M | 0.00% | Share |
| 25 | JANE STREET GROUP, LLC | 666,875 | $18.0M | 0.00% | Share |
| 26 | BALYASNY ASSET MANAGEMENT L.P. | 635,069 | $17.0M | 0.02% | Share |
| 27 | SCS Capital Management LLC | 598,765 | $16.3M | 0.17% | Share |
| 28 | BlackRock, Inc. | 592,696 | $16.0M | 0.00% | Share |
| 29 | PRICE T ROWE ASSOCIATES INC /MD/ | 570,898 | $15.0M | 0.00% | Share |
| 30 | Connor, Clark & Lunn Investment Management Ltd. | 562,642 | $15.0M | 0.04% | Share |
| 31 | Foresite Capital Management VI LLC | 530,000 | $14.4M | 4.36% | Share |
| 32 | MORGAN STANLEY | 541,101 | $14.0M | 0.00% | Share |
| 33 | D. E. Shaw & Co., Inc. | 484,524 | $13.0M | 0.01% | Share |
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 482,622 | $13.0M | 0.00% | Share |
| 35 | Artisan Partners Limited Partnership | 504,485 | $13.0M | 0.02% | Share |
| 36 | ArrowMark Colorado Holdings LLC | 466,151 | $12.7M | 0.28% | Share |
| 37 | NORTHERN TRUST CORP | 451,759 | $12.0M | 0.00% | Share |
| 38 | ALGERT GLOBAL LLC | 414,218 | $11.0M | 0.17% | Share |
| 39 | VANGUARD GROUP INC | 372,819 | $10.1M | 0.00% | Share |
| 40 | MILLENNIUM MANAGEMENT LLC | 398,267 | $10.0M | 0.00% | Share |
| 41 | Qube Research & Technologies Ltd | 378,373 | $10.0M | 0.01% | Share |
| 42 | Vestal Point Capital, LP | 325,000 | $8.8M | 0.30% | Share |
| 43 | Nuveen, LLC | 294,230 | $8.0M | 0.00% | Share |
| 44 | CITADEL ADVISORS LLC | 296,225 | $8.0M | 0.00% | Share |
| 45 | TWO SIGMA INVESTMENTS, LP | 300,156 | $8.0M | 0.01% | Share |
| 46 | BARCLAYS PLC | 319,535 | $8.0M | 0.00% | Share |
| 47 | Legal & General Group Plc | 315,925 | $8.0M | 0.00% | Share |
| 48 | WELLINGTON MANAGEMENT GROUP LLP | 318,609 | $8.0M | 0.00% | Share |
| 49 | JANE STREET GROUP, LLC | 324,206 | $8.0M | 0.00% | Share |
| 50 | MARSHALL WACE, LLP | 302,063 | $8.0M | 0.01% | Share |