BAKER BROS. ADVISORS LP Q2 2022 Filing

Filed August 15, 2022

Portfolio Value

$17.6T

Holdings

117

Report Date

Q2 2022

Filing Type

13F-HR

All Holdings (117 positions)

#StockSharesValue% PortfolioType
1
SGENUSDSeagen Inc.
46,912,266$8.3T47.09%
2
INCYIncyte Corporation
36,154,117$2.7T15.58%
3
ONCBeiGene, Ltd.
11,668,897$1.9T10.71%
4
BMRNBioMarin Pharmaceutical Inc.
7,620,494$631.5B3.58%
5
ACADACADIA Pharmaceuticals Inc.
41,923,486$590.7B3.35%
6
ASNDAscendis Pharma A/S
4,852,655$451.1B2.56%
7
ARGXargenx SE
1,119,557$424.2B2.41%
8
BCRXBioCryst Pharmaceuticals, Inc.
12,710,818$134.5B0.76%
9
KODKodiak Sciences Inc.
17,310,490$132.3B0.75%
10
GBTUSDGlobal Blood Therapeutics, Inc.
3,732,502$119.3B0.68%
11
ABCLAbCellera Biologics Inc.
10,450,180$111.3B0.63%
12
MDGLMadrigal Pharmaceuticals, Inc.
1,499,213$107.3B0.61%
13
MRTXEURMirati Therapeutics, Inc.
1,409,784$94.6B0.54%
14
IMCRImmunocore Holdings plc
2,520,730$94.0B0.53%
15
HZNPHorizon Therapeutics Public Ltd Co
1,148,504$91.6B0.52%
16
CERSCerus Corporation
16,067,558$85.0B0.48%
17
TVTXTravere Therapeutics, Inc.
3,300,009$80.0B0.45%
18
REPLReplimune Group, Inc.
3,591,081$62.8B0.36%
19
TRDAEntrada Therapeutics, Inc.
4,865,819$59.3B0.34%
20
1K0IGM Biosciences, Inc.
3,156,102$56.9B0.32%
21
KYMRKymera Therapeutics, Inc.
2,879,825$56.7B0.32%
22
KRYSKrystal Biotech, Inc.
807,735$53.0B0.30%
23
PRLDPrelude Therapeutics Inc.
10,123,824$52.8B0.30%
24
NRIXNurix Therapeutics, Inc.
3,882,125$49.2B0.28%
25
LEGNLegend Biotech Corporation
856,658$47.1B0.27%
26
ALKSAlkermes plc
1,500,000$44.7B0.25%
27
CCXIEURChemoCentryx, Inc.
1,792,657$44.4B0.25%
28
290AChinook Therapeutics, Inc.
2,534,102$44.3B0.25%
29
IM8NInsmed Incorporated
2,156,001$42.5B0.24%
30
IMTXImmatics N.V.
4,423,731$38.5B0.22%
31
DBV Technologies S.A.
14,614,264$37.3B0.21%
32
SRPT 1.5 11/15/24Sarepta Therapeutics, Inc.
29,174,000$36.6B0.21%
33
INSM 0.75 06/01/28Insmed Incorporated
40,000,000$33.3B0.19%
34
AVTEAerovate Therapeutics, Inc.
2,070,010$32.4B0.18%
35
AMRNAmarin Corporation plc
21,169,805$31.5B0.18%
36
VSTMVerastem, Inc.
26,988,898$31.3B0.18%
37
RAREUltragenyx Pharmaceutical Inc.
470,974$28.1B0.16%
38
TSVT*2seventy bio, Inc.
2,062,744$27.2B0.15%
39
KNSAKiniksa Pharmaceuticals, Ltd.
2,799,577$27.1B0.15%
40
BMEABiomea Fusion, Inc.
2,104,559$25.2B0.14%
41
ALTAltimmune, Inc.
2,075,403$24.3B0.14%
42
NVTA1EURInvitae Corporation
9,873,488$24.1B0.14%
43
PACBPacific Biosciences of California, Inc.
5,444,963$24.1B0.14%
44
XENEXenon Pharmaceuticals Inc.
751,639$22.9B0.13%
45
HRTXHeron Therapeutics, Inc.
8,131,678$22.7B0.13%
46
MRUSMerus N.V.
995,397$22.5B0.13%
47
VERVVerve Therapeutics, Inc.
1,416,530$21.6B0.12%
48
DSGNDesign Therapeutics, Inc.
1,436,636$20.1B0.11%
49
Affimed N.V.
6,596,830$18.3B0.10%
50
TILInstil Bio, Inc.
3,893,700$18.0B0.10%
51
OTICEUROtonomy, Inc.
8,412,634$17.5B0.10%
52
DNLIDenali Therapeutics Inc.
588,738$17.3B0.10%
53
RYTMRhythm Pharmaceuticals, Inc.
4,125,062$17.1B0.10%
54
OPTEYOpthea Limited
2,696,191$17.0B0.10%
55
ADAPYAdaptimmune Therapeutics plc
9,830,877$16.7B0.09%
56
CRNXCrinetics Pharmaceuticals, Inc.
827,480$15.4B0.09%
57
1T7Tricida, Inc.
1,503,090$14.6B0.08%
58
Forma Therapeutics Holdings, Inc.
2,024,876$14.0B0.08%
59
FLGTFulgent Genetics, Inc.
201,444$11.0B0.06%
60
bluebird bio, Inc.
2,499,715$10.3B0.06%
61
RLMDRelmada Therapeutics, Inc.
495,113$9.4B0.05%
62
DICE Therapeutics, Inc.
588,235$9.1B0.05%
63
Zymeworks Inc.
1,708,472$9.1B0.05%
64
KRTXKaruna Therapeutics, Inc.
69,966$8.9B0.05%
65
TCRXTScan Therapeutics, Inc.
2,784,792$8.8B0.05%
66
ANABAnaptysBio, Inc.
427,179$8.7B0.05%
67
FGENEURFibroGen, Inc.
815,718$8.6B0.05%
68
Invitae Corporation
10,300,000$8.1B0.05%
69
CYTCyteir Therapeutics, Inc.
2,643,640$7.9B0.04%
70
SRZNSurrozen, Inc.
2,500,000$7.5B0.04%
71
RETAEURReata Pharmaceuticals, Inc.
223,976$6.8B0.04%
72
698Achilles Therapeutics plc
2,591,366$6.5B0.04%
73
CBAYUSDCymaBay Therapeutics, Inc.
2,170,464$6.4B0.04%
74
BCELAtreca, Inc.
3,532,760$6.3B0.04%
75
Talis Biomedical Corporation
7,624,835$6.2B0.04%
76
HRMYHarmony Biosciences Holdings, Inc.
123,600$6.0B0.03%
77
ATRAGBXAtara Biotherapeutics, Inc.
744,186$5.8B0.03%
78
VORVor Biopharma Inc.
1,138,768$5.7B0.03%
79
CNTACentessa Pharmaceuticals plc
1,127,273$5.5B0.03%
80
NKTXNkarta, Inc.
400,000$4.9B0.03%
81
VERAVera Therapeutics, Inc.
333,333$4.5B0.03%
82
RVMDRevolution Medicines, Inc.
222,222$4.3B0.02%
83
EWTXEdgewise Therapeutics, Inc.
500,000$4.0B0.02%
84
Neoleukin Therapeutics, Inc.
3,821,740$3.9B0.02%
85
HOOKGBPHOOKIPA Pharma Inc.
2,400,481$3.9B0.02%
86
NTRANatera, Inc.
100,000$3.5B0.02%
87
TNGXTango Therapeutics, Inc.
750,000$3.4B0.02%
88
Athira Pharma, Inc.
1,040,834$3.2B0.02%
89
5E7iTeos Therapeutics, Inc.
150,346$3.1B0.02%
90
Evofem Biosciences, Inc.
2,583,616$2.9B0.02%
91
MGNXMacroGenics, Inc.
892,579$2.6B0.01%
92
ALGSAligos Therapeutics, Inc.
2,076,400$2.5B0.01%
93
ALECAlector, Inc.
239,228$2.4B0.01%
94
BCABBioAtla, Inc.
825,000$2.4B0.01%
95
ALLKGUSDAllakos Inc.
703,050$2.2B0.01%
96
TCR2 Therapeutics Inc.
753,064$2.2B0.01%
97
SNDXSyndax Pharmaceuticals, Inc.
110,729$2.1B0.01%
98
AGLEUSDAeglea BioTherapeutics, Inc.
3,410,106$1.7B0.01%
99
Epizyme, Inc.
1,000,000$1.5B0.01%
100
AKROAkero Therapeutics, Inc.
118,378$1.1B0.01%
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