GREAT POINT PARTNERS LLC
CIK: 0001281446Latest portfolio: $308.4M · Q4 2025
Holdings
29
Total Value
$308.4M
New Positions
12
Closed Positions
13
Top Holdings
View All 29 Holdings →| # | Stock | Shares | Value | % Portfolio | Change | Type |
|---|---|---|---|---|---|---|
| 1 | APGEAPOGEE THERAPEUTICS INC | 374,000 | $28.2M | 9.15% | +70K | |
| 2 | AMLXAMYLYX PHARMACEUTICALS INC | 1,750,000 | $21.1M | 6.85% | +50K | |
| 3 | ZURAZURA BIO LTD | 3,815,930 | $20.0M | 6.48% | — | |
| 4 | IRONDISC MEDICINE INC | 250,000 | $19.9M | 6.44% | NEW | |
| 5 | RAPTRAPT THERAPEUTICS INC | 581,187 | $19.7M | 6.38% | NEW | |
| 6 | IMVTIMMUNOVANT INC | 750,000 | $19.1M | 6.18% | +250K | |
| 7 | SLNOSOLENO THERAPEUTICS INC | 400,000 | $18.5M | 6.00% | +175K | |
| 8 | VORVOR BIOPHARMA INC | 1,370,107 | $17.9M | 5.81% | NEW | |
| 9 | DNTHDIANTHUS THERAPEUTICS INC | 350,000 | $14.4M | 4.68% | +84K | |
| 10 | JBIOJADE BIOSCIENCES INC | 806,273 | $12.4M | 4.03% | +174K | |
| 11 | KALVKALVISTA PHARMACEUTICALS INC | 685,632 | $11.1M | 3.59% | NEW | |
| 12 | CTNMCONTINEUM THERAPEUTICS INC | 800,000 | $9.1M | 2.96% | NEW | |
| 13 | EPRXEUPRAXIA PHARMACEUTICALS INC | 1,200,000 | $9.1M | 2.94% | — | |
| 14 | FULCFULCRUM THERAPEUTICS INC | 800,000 | $9.0M | 2.93% | NEW | |
| 15 | NKTRNEKTAR THERAPEUTICS | 210,732 | $8.9M | 2.89% | -89,268 | |
| 16 | UPBUPSTREAM BIO INC | 300,000 | $8.1M | 2.64% | — | |
| 17 | NGNENEUROGENE INC | 350,000 | $7.2M | 2.34% | -96,814 | |
| 18 | RAREULTRAGENYX PHARMACEUTICAL IN | 300,000 | $6.9M | 2.24% | NEW | |
| 19 | CNTXCONTEXT THERAPEUTICS INC | 4,683,711 | $6.9M | 2.23% | — | |
| 20 | CGEMCULLINAN THERAPEUTICS INC | 634,032 | $6.6M | 2.13% | NEW | |
| 21 | EVMNEVOMMUNE INC | 325,000 | $5.6M | 1.80% | NEW | |
| 22 | ORKAORUKA THERAPEUTICS INC | 183,330 | $5.6M | 1.80% | — | |
| 23 | SLNSILENCE THERAPEUTICS PLC | 808,032 | $4.9M | 1.59% | NEW | |
| 24 | UNCYUNICYCIVE THERAPEUTICS INC | 796,558 | $4.6M | 1.49% | — | |
| 25 | CLYMCLIMB BIO INC | 979,534 | $3.9M | 1.27% | NEW |
Quarterly Changes
New Positions
Sector Breakdown
Healthcare100.0% ($2.822921140199952e+117T)
Filing History
Fund Information
GREAT POINT PARTNERS LLC is an institutional investment manager that files 13F reports with the SEC. As of the Q4 2025 filing, the fund reported a portfolio valued at $308.4M across 29 holdings. The largest position is APOGEE THERAPEUTICS INC (APGE), representing 9.2% of the portfolio. Compared to the previous quarter, the fund opened 12 new positions and closed 13 positions. 13F filings are required quarterly disclosures that provide transparency into the holdings of institutional investment managers with at least $100 million in qualifying assets.