Opaleye Management Inc. Q4 2023 Filing

Filed February 14, 2024

Portfolio Value

$376.1B

Holdings

46

Report Date

Q4 2023

Filing Type

13F-HR

All Holdings (46 positions)

#StockSharesValue% PortfolioType
1
HROWHARROW HEALTH INC
3,820,000$42.8B11.38%
2
TGTXTG THERAPEUTICS INC
2,215,000$37.8B10.06%
3
SLRNACELYRIN INC
4,146,138$30.9B8.22%
4
RYTMRHYTHM PHARMACEUTICALS INC
610,000$28.0B7.46%
5
OCULOCULAR THERAPEUTIX INC
6,070,000$27.1B7.20%
6
CPRXCATALYST PHARMACEUTICALS INC
1,257,200$21.4B5.70%
7
KROSKEROS THERAPEUTICS INC
357,500$14.2B3.78%
8
IDYAIDEAYA BIOSCIENCES INC
311,500$11.1B2.95%
9
ETONETON PHARMACEUTICALS INC
2,529,887$11.1B2.95%
10
CRNXCRINETICS PHARMACEUTICALS INC
307,500$10.9B2.91%
11
ARVNARVINAS INC
263,700$10.9B2.89%
12
CDXSCODEXIS INC
3,045,525$9.3B2.47%
13
BHVNBIOHAVEN LTD
200,000$8.6B2.28%
14
EWTXEDGEWISE THERAPEUTICS INC
699,000$7.6B2.03%
15
IOVAIOVANCE BIOTHERAPEUTICS INC
897,000$7.3B1.94%
16
ARQTARCUTIS BIOTHERAPEUTICS INC
1,960,000$6.3B1.68%
17
FDMT4D MOLECULAR THERAPEUTICS INC
308,500$6.3B1.66%
18
MRNS*MARINUS PHARMACEUTICALS INC
563,500$6.1B1.63%
19
PCVXVAXCYTE INC
90,000$5.7B1.50%
20
LQDALIQUIDIA CORPORATION
445,000$5.4B1.42%
21
TARAPROTARA THERAPEUTICS INC
2,692,594$5.0B1.34%
22
URGNUROGEN PHARMA LTD
320,000$4.8B1.28%
23
XOMAXOMA CORP DEL
250,000$4.6B1.23%
24
APLTAPPLIED THERAPEUTICS
1,092,500$3.7B0.97%
25
RLMDRELMADA THERAPEUTICS INC
877,000$3.6B0.97%
26
TRVITREVI THERAPEUTICS INC
2,535,000$3.4B0.90%
27
JSPRJASPER THERAPEUTICS INC
3,985,340$3.1B0.84%
28
NTLAINTELLIA THERAPEUTICS INC
99,000$3.0B0.80%
29
NAMSNEWAMSTERDAM PHARMA COMPANY
265,388$3.0B0.79%
30
GOSS 5 06/01/27GOSSAMER BIO INC
8,000,000$2.9B0.78%
31
LRMRLARIMAR THERAPEUTICS INC
623,500$2.8B0.75%
32
BDSXBRIDGEBIO PHARMA INC
70,000$2.8B0.75%
33
VTYXVENTYX BIOSCIENCES INC
1,140,000$2.8B0.75%
34
SYRSSYROS PHARMACEUTICALS INC
359,370$2.8B0.74%
35
GOSSGOSSAMER BIO INC
2,982,200$2.7B0.72%
36
PTGXPROTAGONIST THERAPEUTICS INC
112,700$2.6B0.69%
37
KALVKALVISTA PHARMACEUTICALS INC
150,000$1.8B0.49%
38
VSTMVERASTEM INC
211,400$1.7B0.46%
39
NYXHNYXOAH S A
344,800$1.6B0.43%
40
MOR2MORPHOSYS AG
145,000$1.4B0.38%
41
PGENPRECIGEN INC
1,012,500$1.4B0.36%
42
STROSUTRO BIOPHARMA INC
301,491$1.3B0.34%
43
CNTXCONTEXT THERAPEUTICS INC
975,000$1.1B0.29%
44
FULCFULCRUM THERAPEUTICS INC
130,000$877.5M0.23%
45
ALGSALIGOS THERAPEUTICS INC
1,297,000$861.2M0.23%
46
BDSXBIODESIX
426,500$784.8M0.21%
47
KNSAKINIKSA PHARMACEUTICALS LTD
37,500$640.2M0.17%