Paradigm Biocapital Advisors LP Q3 2025 Filing

Filed November 14, 2025

Portfolio Value

$3.5T

Holdings

34

Report Date

Q3 2025

Filing Type

13F-HR

All Holdings (34 positions)

#StockSharesValue% PortfolioType
1
NUVLNUVALENT INC
5,269,433$455.7B12.96%
2
MRUSMERUS N V
4,673,770$440.0B12.51%Call
3
ACLXARCELLX INC
4,649,016$381.7B10.86%
4
RVMDREVOLUTION MEDICINES INC
6,223,291$290.6B8.27%
5
TARSTARSUS PHARMACEUTICALS INC
2,665,698$158.4B4.51%
6
PCVXVAXCYTE INC
3,784,755$136.3B3.88%
7
ABVXABIVAX SA
1,564,196$132.8B3.78%
8
GMABGENMAB A/S
3,816,851$117.1B3.33%
9
AGIOAGIOS PHARMACEUTICALS INC
2,873,555$115.3B3.28%Call
10
CRNXCRINETICS PHARMACEUTICALS IN
2,550,774$106.2B3.02%
11
XBISPDR SERIES TRUST
1,000,000$100.2B2.85%Put
12
EWTXEDGEWISE THERAPEUTICS INC
6,170,131$100.1B2.85%
13
CDTXCIDARA THERAPEUTICS INC
961,164$92.0B2.62%
14
URGNUROGEN PHARMA LTD
4,216,084$84.1B2.39%
15
SRRKSCHOLAR ROCK HLDG CORP
2,009,745$74.8B2.13%
16
JANXJANUX THERAPEUTICS INC
2,920,258$71.4B2.03%
17
OLMAOLEMA PHARMACEUTICALS INC
6,794,172$66.5B1.89%
18
APGEAPOGEE THERAPEUTICS INC
1,521,757$60.5B1.72%
19
VRDNVIRIDIAN THERAPEUTICS INC
2,609,353$56.3B1.60%
20
ALKSALKERMES PLC
1,719,334$51.6B1.47%
21
LENZLENZ THERAPEUTICS INC
1,073,461$50.0B1.42%
22
PHVSPHARVARIS N V
1,835,494$45.8B1.30%
23
COGTCOGENT BIOSCIENCES INC
3,156,398$45.3B1.29%
24
OCULOCULAR THERAPEUTIX INC
3,497,307$40.9B1.16%
25
BBIOBRIDGEBIO PHARMA INC
684,277$35.5B1.01%
26
ERASERASCA INC
13,560,017$29.6B0.84%
27
EYPTEYEPOINT PHARMACEUTICALS INC
2,005,365$28.6B0.81%
28
TNGXTANGO THERAPEUTICS INC
3,086,184$25.9B0.74%
29
AMLXAMYLYX PHARMACEUTICALS INC
1,900,000$25.8B0.73%
30
SYRESPYRE THERAPEUTICS INC
1,467,266$24.6B0.70%
31
DYNDYNE THERAPEUTICS INC
1,898,950$24.0B0.68%
32
BBOTBRIDGEBIO ONCOLOGY THERAPEUT
1,866,141$21.6B0.61%
33
IRONDISC MEDICINE INC
247,716$16.4B0.47%
34
GPCRSTRUCTURE THERAPEUTICS INC
372,869$10.4B0.30%