HighVista Strategies LLC

CIK: 0001335325Latest portfolio: $388.0M · Q4 2025

Holdings

145

Total Value

$388.0M

New Positions

33

Closed Positions

36

#StockSharesValue% PortfolioChangeType
1
DBCINVESCO DB COMMDY INDX TRCK
1,057,238$23.0M5.93%-378,898
2
GPCRSTRUCTURE THERAPEUTICS INC
193,001$13.0M3.35%-43,235
3
COGTCOGENT BIOSCIENCES INC
336,667$11.0M2.84%-125,738
4
VRDNVIRIDIAN THERAPEUTICS INC
372,472$11.0M2.84%-96,863
5
RVMDREVOLUTION MEDICINES INC
120,240$9.0M2.32%-55,208
6
ABVXABIVAX SA
72,185$9.0M2.32%-112,283
7
CYTKCYTOKINETICS INC
114,564$7.0M1.80%-18,366
8
TERNTERNS PHARMACEUTICALS INC
175,462$7.0M1.80%NEW
9
NUVLNUVALENT INC
73,287$7.0M1.80%-20,007
10
MAZEMAZE THERAPEUTICS INC
170,353$7.0M1.80%NEW
11
PRAXPRAXIS PRECISION MEDICINES I
25,841$7.0M1.80%-69,161
12
SLNOSOLENO THERAPEUTICS INC
135,069$6.0M1.55%+116K
13
BBIOBRIDGEBIO PHARMA INC
80,205$6.0M1.55%-1,754
14
IM8NINSMED INC
39,400$6.0M1.55%-10,549
15
SYRESPYRE THERAPEUTICS INC
188,206$6.0M1.55%-27,540
16
OLMAOLEMA PHARMACEUTICALS INC
241,489$6.0M1.55%-195,690
17
APGEAPOGEE THERAPEUTICS INC
89,229$6.0M1.55%-17,878
18
PTGXPROTAGONIST THERAPEUTICS INC
73,545$6.0M1.55%-48,137
19
LQDALIQUIDIA CORPORATION
156,003$5.0M1.29%-20,482
20
PCVXVAXCYTE INC
114,049$5.0M1.29%+27K
21
IMVTIMMUNOVANT INC
221,883$5.0M1.29%-31,244
22
CDTXCIDARA THERAPEUTICS INC
22,928$5.0M1.29%-47,976
23
AMZNAMAZON COM INC
17,397$4.0M1.03%-8,996
24
OCULOCULAR THERAPEUTIX INC
344,067$4.0M1.03%+237K
25
PHVSPHARVARIS N V
162,370$4.0M1.03%NEW

Quarterly Changes

New Positions

Closed Positions

Increased Positions

NameSharesChange
RLAY545K+305K
OCUL344K+237K
AVTX96K+68K
TARS54K+29K
RXO91K+10K
XOMA113K+7K
RYTM43K+5K
APLS151K+5K
NAMS36K+4K
NEE19K+4K

Decreased Positions

NameSharesChange
DBC1.1M-378898
BBD190K-329836
OLMA241K-195690
COGT337K-125738
VRDN372K-96863
MLYS125K-85285
PRAX26K-69161
CTMX194K-63207
RVMD120K-55208
BVN30K-53282

Sector Breakdown

Healthcare0.0% ($1.300011000110009e+231T)
Technology0.0% ($3.0002000200009998e+54T)
Industrials0.0% ($1.000100010001e+38T)
Financial Services0.0% ($2.3000200010001e+22T)
Unknown0.0% ($6000500020001001472.0T)
Utilities0.0% ($1000100010.0T)
Consumer Cyclical0.0% ($400.0T)
Communication Services0.0% ($100.0T)
Basic Materials0.0% ($100.0B)
Energy0.0% ($10.0M)

Filing History

QuarterFiling DatePortfolio ValueHoldings
Q4 2025Feb 17, 2026$388.0M145
Q3 2025Nov 14, 2025$408.0B148
Q2 2025Aug 14, 2025$272.1B146
Q1 2025May 15, 2025$259.5B148
Q4 2024Feb 14, 2025$268.8B137

Fund Information

CIK0001335325
Most Recent FilingFeb 17, 2026
Number of Filings5

HighVista Strategies LLC is an institutional investment manager that files 13F reports with the SEC. As of the Q4 2025 filing, the fund reported a portfolio valued at $388.0M across 145 holdings. The largest position is INVESCO DB COMMDY INDX TRCK (DBC), representing 5.9% of the portfolio. Compared to the previous quarter, the fund opened 33 new positions and closed 36 positions. 13F filings are required quarterly disclosures that provide transparency into the holdings of institutional investment managers with at least $100 million in qualifying assets.