ORBIMED ADVISORS LLC Q1 2019 Filing

Filed May 15, 2019

Portfolio Value

$6.5B

Holdings

119

Report Date

Q1 2019

Filing Type

13F-HR

All Holdings (119 positions)

#StockSharesValue% PortfolioType
1
ASNDASCENDIS PHARMA A S
3,970,673$467.3B7234.81%
2
1T7TRICIDA INC
10,889,280$420.5B6510.26%
3
CLEMENTIA PHARMACEUTICALS IN
10,425,225$272.1B4212.23%
4
ALXNALEXION PHARMACEUTICALS INC
1,957,200$264.6B4095.76%
5
ALECALECTOR INC
13,182,329$246.8B3820.19%
6
BSXBOSTON SCIENTIFIC CORP
5,790,400$222.2B3440.34%
7
MRKMERCK & CO INC
2,570,100$213.8B3309.05%
8
VRTXVERTEX PHARMACEUTICALS INC
955,300$175.7B2720.35%
9
NBIXNEUROCRINE BIOSCIENCES INC
1,833,200$161.5B2500.19%
10
WRIGHT MED GROUP N V
4,437,799$139.6B2160.61%Call
11
MYLAN N V
4,861,800$137.8B2132.96%
12
EWEDWARDS LIFESCIENCES CORP
715,000$136.8B2117.76%
13
TMOTHERMO FISHER SCIENTIFIC INC
447,300$122.4B1895.36%
14
ISRGINTUITIVE SURGICAL INC
210,300$120.0B1857.56%
15
GHGUARDANT HEALTH INC
1,534,464$117.7B1821.95%
16
SYNTHORX INC
5,316,355$108.3B1676.45%
17
SRPTSAREPTA THERAPEUTICS INC
828,400$98.7B1528.50%
18
ELVANTHEM INC
325,200$93.3B1444.74%
19
BHCBAUSCH HEALTH COS INC
3,740,700$92.4B1430.33%
20
PRINCIPIA BIOPHARMA INC
2,605,713$88.6B1371.49%
21
REGNREGENERON PHARMACEUTICALS
214,800$88.2B1365.40%
22
DCPHEURDECIPHERA PHARMACEUTICALS IN
3,618,171$84.0B1300.03%
23
INSPINSPIRE MED SYS INC
1,471,000$83.5B1292.98%
24
IMMUNOMEDICS INC
4,270,403$82.0B1269.93%
25
EHTHEHEALTH INC
1,181,214$73.6B1139.94%
26
PBYIPUMA BIOTECHNOLOGY INC
1,880,000$72.9B1128.92%
27
AUDENTES THERAPEUTICS INC
1,815,000$70.8B1096.35%
28
ILMNILLUMINA INC
227,300$70.6B1093.24%
29
CLVSEURCLOVIS ONCOLOGY INC
2,832,300$70.3B1088.25%
30
EX9EXELIXIS INC
2,801,900$66.7B1032.32%
31
AG8AGILENT TECHNOLOGIES INC
798,700$64.2B993.85%
32
TEVATEVA PHARMACEUTICAL INDS LTD
4,079,000$64.0B990.12%
33
LOGICBIO THERAPEUTICS INC
6,466,783$63.9B989.08%
34
PTCTPTC THERAPEUTICS INC
1,519,700$57.2B885.52%
35
BMYBRISTOL MYERS SQUIBB CO
1,195,000$57.0B882.59%
36
HUMHUMANA INC
210,300$55.9B865.98%
37
IOVAIOVANCE BIOTHERAPEUTICS INC
5,548,326$52.8B816.83%
38
AVEDRO INC
4,240,128$52.0B805.39%
39
ENDO INTL PLC
6,165,464$49.5B766.43%
40
ABTABBOTT LABS
615,400$49.2B761.57%
41
MYOKARDIA INC
906,600$47.1B729.66%
42
ARGXARGENX SE
361,300$45.1B698.25%
43
CRNXCRINETICS PHARMACEUTICALS IN
1,914,282$43.6B674.47%
44
MGTXMEIRAGTX HOLDINGS PLC
2,460,251$42.4B656.22%
45
ZLABZAI LAB LTD
1,401,318$41.4B640.17%
46
CICIGNA CORP NEW
252,600$40.6B628.87%
47
TNDMTANDEM DIABETES CARE INC
631,300$40.1B620.59%
48
ARVNARVINAS INC
2,678,810$39.5B612.09%
49
VRAYQVIEWRAY INC
5,149,019$38.1B589.05%
50
ONCBEIGENE LTD
282,500$37.3B577.27%
51
APLSAPELLIS PHARMACEUTICALS INC
1,837,300$35.8B554.64%Call
52
TAKTAKEDA PHARMACEUTICAL CO LTD
1,750,000$35.6B551.85%Call
53
OBSEVA SA
2,605,531$33.3B515.89%
54
RESTORBIO INC
4,830,387$32.9B509.98%
55
PRTAPROTHENA CORP PLC
2,435,278$29.5B457.30%
56
GNFTYGENFIT S A
1,230,314$29.5B457.11%
57
BMRNBIOMARIN PHARMACEUTICAL INC
326,500$29.0B448.98%Put
58
GILDGILEAD SCIENCES INC
443,800$28.9B446.63%
59
KALAKALA PHARMACEUTICALS INC
3,447,840$28.5B441.41%
60
XTNTXTANT MED HLDGS INC
9,207,012$28.1B434.71%
61
CELGCELGENE CORP
295,000$27.8B430.82%
62
PRQRPROQR THRAPEUTICS N V
1,982,031$27.5B425.58%
63
HRTXHERON THERAPEUTICS INC
1,069,000$26.1B404.45%
64
CDNACAREDX INC
827,600$26.1B403.83%
65
NVLSEURALPINE IMMUNE SCIENCES INC
3,670,955$25.2B389.85%
66
CBAYUSDCYMABAY THERAPEUTICS INC
1,874,955$24.9B385.45%
67
CRVSCORVUS PHARMACEUTICALS INC
5,967,584$24.0B371.38%
68
AMGNAMGEN INC
122,100$23.2B359.10%
69
HARPOON THERAPEUTICS INC
2,446,409$23.2B358.64%
70
ENTAENANTA PHARMACEUTICALS INC
233,100$22.3B344.69%
71
NTRANATERA INC
1,077,586$22.2B343.98%
72
RYTMRHYTHM PHARMACEUTICALS INC
787,300$21.6B334.07%
73
BIIBBIOGEN INC
87,700$20.7B320.93%
74
AUPHAURINIA PHARMACEUTICALS INC
3,149,810$20.5B316.95%
75
ASMBASSEMBLY BIOSCIENCES INC
996,123$19.6B303.64%
76
FOAMIX PHARMACEUTICALS LTD
5,195,330$19.5B301.59%
77
SIBNSI BONE INC
985,368$18.6B287.38%
78
SVASINOVAC BIOTECH LTD
2,839,500$18.4B284.41%
79
AGLEUSDAEGLEA BIOTHERAPEUTICS INC
2,165,524$17.4B269.86%
80
NVONOVO-NORDISK A S
330,000$17.3B267.23%
81
AMRNAMARIN CORP PLC
817,600$17.0B262.75%Call
82
DC4DEXCOM INC
138,700$16.5B255.72%
83
VRCAVERRICA PHARMACEUTICALS INC
1,479,733$16.0B247.63%
84
SYNLOGIC INC
2,029,996$15.4B238.52%
85
SPYSPDR S&P 500 ETF TR
50,000$14.1B218.65%Put
86
NABRIVA THERAPEUTICS PLC
4,644,600$11.3B175.44%
87
CONSTELLATION PHARMCETICLS I
835,842$11.3B175.33%
88
SYKSTRYKER CORP
54,000$10.7B165.12%
89
SCPHSCPHARMACEUTICALS INC
3,409,865$10.2B158.37%
90
NOVUS THERAPEUTICS INC
2,537,110$10.2B157.89%
91
MERSANA THERAPEUTICS INC
1,891,119$9.9B153.99%
92
VRNAVERONA PHARMA PLC
1,250,396$8.1B125.83%
93
AM6AMICUS THERAPEUTICS INC
518,309$7.0B109.12%
94
WVEWAVE LIFE SCIENCES LTD
180,000$7.0B108.26%Put
95
SELBUSDSELECTA BIOSCIENCES INC
2,879,064$6.8B105.62%
96
ADVMCHFADVERUM BIOTECHNOLOGIES INC
1,243,200$6.5B100.84%
97
SPROSPERO THERAPEUTICS INC
507,471$6.5B100.64%
98
XENEXENON PHARMACEUTICALS INC
634,812$6.5B99.85%
99
NTLAINTELLIA THERAPEUTICS INC
377,600$6.4B99.83%
100
ADAPYADAPTIMMUNE THERAPEUTICS PLC
1,350,655$5.8B89.91%
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