ORBIMED ADVISORS LLC Q4 2022 Filing
Filed February 14, 2023
Portfolio Value
$5.2B
Holdings
115
Report Date
Q4 2022
Filing Type
13F-HR
All Holdings (115 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | SVASINOVAC BIOTECH LTD | 2,718,735 | $340.0T | 6504117.30% | |
| 2 | UNHUNITEDHEALTH GROUP INC | 380,500 | $201.7T | 3859112.59% | |
| 3 | BMYBRISTOL-MYERS SQUIBB CO | 2,584,900 | $186.0T | 3557820.17% | |
| 4 | BSXBOSTON SCIENTIFIC CORP | 3,898,200 | $180.4T | 3450428.76% | |
| 5 | HUMHUMANA INC | 348,700 | $178.6T | 3416587.05% | |
| 6 | BMRNBIOMARIN PHARMACEUTICAL INC | 1,615,210 | $167.2T | 3197693.47% | |
| 7 | ISRGINTUITIVE SURGICAL INC | 620,500 | $164.6T | 3149708.23% | |
| 8 | SWTXSPRINGWORKS THERAPEUTICS INC | 5,250,000 | $136.6T | 2612216.11% | |
| 9 | EWTXEDGEWISE THERAPEUTICS INC | 14,567,176 | $130.2T | 2491278.80% | |
| 10 | SRPTSAREPTA THERAPEUTICS INC | 972,300 | $126.0T | 2410170.18% | |
| 11 | VRNAVERONA PHARMA PLC | 4,572,289 | $119.5T | 2285506.88% | |
| 12 | SYKSTRYKER CORPORATION | 481,000 | $117.6T | 2249653.46% | |
| 13 | SGENUSDSEAGEN INC | 913,812 | $117.4T | 2246483.47% | |
| 14 | CMPXCOMPASS THERAPEUTICS INC | 22,362,850 | $112.5T | 2151813.29% | |
| 15 | TMOTHERMO FISHER SCIENTIFIC INC | 202,200 | $111.3T | 2130089.19% | |
| 16 | —THESEUS PHARMACEUTICALS INC | 17,233,668 | $85.8T | 1641785.87% | |
| 17 | NBIXNEUROCRINE BIOSCIENCES INC | 687,700 | $82.1T | 1571296.95% | |
| 18 | KROSKEROS THERAPEUTICS INC | 1,679,417 | $80.6T | 1542730.79% | |
| 19 | EVHEVOLENT HEALTH INC | 2,824,832 | $79.3T | 1517396.85% | |
| 20 | VRTXVERTEX PHARMACEUTICALS INC | 271,500 | $78.4T | 1499845.05% | |
| 21 | NTRANATERA INC | 1,946,353 | $78.2T | 1495660.03% | |
| 22 | TERNTERNS PHARMACEUTICALS INC | 7,619,135 | $77.6T | 1483757.38% | |
| 23 | ISIIONIS PHARMACEUTICALS INC | 1,993,600 | $75.3T | 1440437.63% | |
| 24 | SPRYARS PHARMACEUTICALS INC | 8,740,887 | $74.6T | 1426310.19% | |
| 25 | BIIBBIOGEN INC | 258,200 | $71.5T | 1367791.84% | |
| 26 | PFEPFIZER INC | 1,393,600 | $71.4T | 1366018.89% | |
| 27 | TORCEURADICET BIO INC | 7,447,140 | $66.6T | 1273610.08% | |
| 28 | EWEDWARDS LIFESCIENCES CORP | 860,500 | $64.2T | 1228166.83% | |
| 29 | PCVXVAXCYTE INC | 1,283,126 | $61.5T | 1176975.35% | |
| 30 | —VECTIVBIO HLDG AG | 7,006,861 | $60.7T | 1161452.68% | |
| 31 | PRLDPRELUDE THERAPEUTICS INC | 10,039,691 | $60.6T | 1160023.36% | |
| 32 | THCTENET HEALTHCARE CORP | 1,220,300 | $59.5T | 1138955.82% | |
| 33 | CRNXCRINETICS PHARMACEUTICALS IN | 3,196,876 | $58.5T | 1119144.93% | |
| 34 | MRTXEURMIRATI THERAPEUTICS INC | 1,283,692 | $58.2T | 1112664.80% | |
| 35 | PMVPPMV PHARMACEUTICALS INC | 6,563,077 | $57.1T | 1092285.58% | |
| 36 | 290ACHINOOK THERAPEUTICS INC | 2,029,300 | $53.2T | 1017084.40% | |
| 37 | —MERSANA THERAPEUTICS INC | 9,011,437 | $52.8T | 1010185.47% | |
| 38 | SNDXSYNDAX PHARMACEUTICALS INC | 2,006,500 | $51.1T | 976869.16% | |
| 39 | RPTXREPARE THERAPEUTICS INC | 3,322,488 | $48.9T | 934943.87% | |
| 40 | XTNTXTANT MED HLDGS INC | 73,114,592 | $48.3T | 923118.48% | |
| 41 | ETNBGBP89BIO INC | 3,658,869 | $46.6T | 891014.37% | |
| 42 | SIBNSI-BONE INC | 3,368,000 | $45.8T | 876234.68% | |
| 43 | XENEXENON PHARMACEUTICALS INC | 1,149,100 | $45.3T | 866750.40% | |
| 44 | ACRSACLARIS THERAPEUTICS INC | 2,758,434 | $43.4T | 831098.71% | |
| 45 | IRONDISC MEDICINE INC | 2,160,941 | $43.0T | 822218.29% | |
| 46 | ABCLABCELLERA BIOLOGICS INC | 4,180,768 | $42.4T | 810167.77% | |
| 47 | SCPHSCPHARMACEUTICALS INC | 5,559,528 | $39.9T | 762546.84% | |
| 48 | QUREUNIQURE NV | 1,747,555 | $39.6T | 757864.95% | |
| 49 | BLUBELLUS HEALTH INC NEW | 4,708,900 | $38.7T | 739534.24% | |
| 50 | JANXJANUX THERAPEUTICS INC | 2,836,386 | $37.4T | 714595.97% | |
| 51 | ARQTARCUTIS BIOTHERAPEUTICS INC | 2,460,108 | $36.4T | 696506.75% | |
| 52 | TELATELA BIO INC | 3,027,542 | $34.8T | 666035.63% | |
| 53 | IMAPRELUDE THERAPEUTICS INC | 5,680,186 | $34.3T | 656309.87% | |
| 54 | ALXOALX ONCOLOGY HLDGS INC | 2,871,000 | $32.4T | 618965.66% | |
| 55 | KZRKEZAR LIFE SCIENCES INC | 4,584,322 | $32.3T | 617386.63% | |
| 56 | PGNYPROGYNY INC | 1,035,000 | $32.2T | 616748.14% | |
| 57 | VTYXVENTYX BIOSCIENCES INC | 925,000 | $30.3T | 580219.87% | |
| 58 | NVLSEURALPINE IMMUNE SCIENCES INC | 4,081,592 | $30.0T | 573886.98% | |
| 59 | TVTXTRAVERE THERAPEUTICS INC | 1,253,130 | $26.4T | 504132.68% | |
| 60 | THRDTHIRD HARMONIC BIO INC | 5,779,071 | $24.9T | 475374.55% | |
| 61 | RAPTEURRAPT THERAPEUTICS INC | 1,251,070 | $24.8T | 473866.76% | |
| 62 | —KINNATE BIOPHARMA INC | 4,043,629 | $24.7T | 471857.20% | |
| 63 | —CINCOR PHARMA INC | 1,906,000 | $23.4T | 448109.58% | |
| 64 | AVTEAEROVATE THERAPEUTICS INC | 759,540 | $22.3T | 425723.59% | |
| 65 | HZNPHORIZON THERAPEUTICS PUB L | 171,000 | $19.5T | 372261.24% | |
| 66 | GRCLGRACELL BIOTECHNOLOGIES INC | 7,884,870 | $18.1T | 346921.98% | |
| 67 | —IMARA INC | 4,386,568 | $17.9T | 343208.17% | |
| 68 | IMAIKENA ONCOLOGY INC | 6,467,691 | $17.2T | 329109.44% | |
| 69 | GHRSGH RESEARCH PLC | 1,622,060 | $15.8T | 301607.84% | |
| 70 | RXSTRXSIGHT INC | 1,202,833 | $15.2T | 291535.47% | |
| 71 | MRNAMODERNA INC | 82,550 | $14.8T | 283648.97% | |
| 72 | IOVAIOVANCE BIOTHERAPEUTICS INC | 2,007,458 | $12.8T | 245389.96% | |
| 73 | BBIO 2.25 02/01/29BRIDGEBIO PHARMA INC | 30,000,000 | $12.6T | 241034.94% | |
| 74 | PASGPASSAGE BIO INC | 8,931,999 | $12.3T | 235796.42% | |
| 75 | —FUSION PHARMACEUTICALS INC | 3,224,770 | $10.2T | 194320.57% | |
| 76 | —DECIBEL THERAPEUTICS INC | 4,945,192 | $10.1T | 193930.66% | |
| 77 | TSVT*2SEVENTY BIO INC | 1,041,300 | $9.8T | 186648.67% | |
| 78 | ORICORIC PHARMACEUTICALS INC | 1,607,568 | $9.5T | 181131.56% | |
| 79 | CMMBCHEMOMAB THERAPEUTICS LTD | 2,578,174 | $8.3T | 157823.50% | |
| 80 | SRRKSCHOLAR ROCK HLDG CORP | 879,003 | $8.0T | 152176.78% | |
| 81 | MREOMEREO BIOPHARMA GROUP PLC | 10,605,522 | $8.0T | 152160.80% | |
| 82 | BBIO 2.5 03/15/27BRIDGEBIO PHARMA INC | 20,000,000 | $8.0T | 152081.57% | |
| 83 | IVVDINVIVYD INC | 5,270,400 | $7.9T | 151232.21% | |
| 84 | —IKENA ONCOLOGY INC | 2,933,941 | $7.8T | 149294.04% | |
| 85 | CGEMCULLINAN ONCOLOGY INC | 637,287 | $6.7T | 128616.59% | |
| 86 | VSTMVERASTEM INC | 16,503,237 | $6.6T | 127070.42% | |
| 87 | XBISPDR SER TR | 76,400 | $6.3T | 121305.61% | |
| 88 | AM6AMICUS THERAPEUTICS INC | 516,000 | $6.3T | 120524.35% | |
| 89 | ARGXARGENX SE | 16,200 | $6.1T | 117400.20% | |
| 90 | NPCENEUROPACE INC | 4,012,281 | $6.0T | 114363.41% | |
| 91 | CRVSCORVUS PHARMACEUTICALS INC | 6,943,654 | $5.9T | 112905.85% | |
| 92 | ASNSUSDX4 PHARMACEUTICALS INC | 5,817,726 | $5.8T | 110512.64% | |
| 93 | VIGLVIGIL NEUROSCIENCE INC | 448,891 | $5.6T | 107339.71% | |
| 94 | BNTXBIONTECH SE | 36,300 | $5.5T | 104314.30% | |
| 95 | SNYSANOFI | 100,000 | $4.8T | 92645.41% | Call |
| 96 | GLTOUSDGALECTO INC | 4,090,937 | $4.7T | 89997.43% | |
| 97 | —SYNLOGIC INC | 6,029,995 | $4.6T | 87667.77% | |
| 98 | NXTCNEXTCURE INC | 2,711,013 | $3.8T | 73124.03% | |
| 99 | AMRXAMNEAL PHARMACEUTICALS INC | 1,583,490 | $3.2T | 60280.64% | |
| 100 | AFIBACUTUS MED INC | 2,648,386 | $3.0T | 58262.43% |
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