Siren, L.L.C. Q3 2024 Filing

Filed November 13, 2024

Portfolio Value

$2000.3T

Holdings

110

Report Date

Q3 2024

Filing Type

13F-HR

All Holdings (110 positions)

#StockSharesValue% PortfolioType
1
KYMRKymera Therapeutics Inc
2,969,733$140.6T7.03%
2
ONCBeigene Ltd
563,314$126.5T6.32%
3
SRRKScholar Rock Holding Corp
11,259,438$90.2T4.51%
4
BCAXBicara Therapeutics Inc
3,072,827$78.3T3.91%
5
ARGXArgenx SE
143,647$77.9T3.89%
6
CRNXCrinetics Pharmaceuticals Inc
1,309,652$66.9T3.35%
7
RNAAvidity Biosciences Inc
1,440,736$66.2T3.31%
8
APLSApellis Pharmaceuticals Inc
2,167,224$62.5T3.12%
9
LXRXLexicon Pharmaceuticals Inc
38,918,903$61.1T3.05%
10
1K0IGM Biosciences Inc
3,330,422$55.1T2.75%
11
CNTACentessa Pharmaceuticals PLC
3,258,677$52.1T2.60%
12
ASNDAscendis Pharma A/S
347,921$51.9T2.60%
13
SLNSilence Therapeutics PLC
2,831,770$51.5T2.57%
14
ARWRArrowhead Pharmaceuticals Inc
2,458,778$47.6T2.38%
15
WVEWAVE Life Sciences Ltd
5,721,172$46.9T2.35%
16
SWTXSpringWorks Therapeutics Inc
1,377,701$44.1T2.21%
17
DYNDyne Therapeutics Inc
1,134,664$40.8T2.04%
18
VERAVera Therapeutics Inc
837,928$37.0T1.85%
19
NMRANeumora Therapeutics Inc
2,606,571$34.4T1.72%
20
PCVXVaxcyte Inc
299,991$34.3T1.71%
21
RVMDRevolution Medicines Inc
753,601$34.2T1.71%
22
MRUSMerus NV
682,201$34.1T1.70%
23
TBLATaboola.com Ltd
9,969,495$33.5T1.67%
24
Longboard Pharmaceuticals Inc
903,227$30.1T1.50%
25
XENEXenon Pharmaceuticals Inc
743,769$29.3T1.46%
26
CYTKCytokinetics Inc
525,971$27.8T1.39%
27
KURAKura Oncology Inc
1,339,942$26.2T1.31%
28
RCUSArcus Biosciences Inc
1,612,077$24.6T1.23%
29
DNLIDenali Therapeutics Inc
834,028$24.3T1.21%
30
ERASErasca Inc
8,857,179$24.2T1.21%
31
CGEMCullinan Therapeutics Inc
1,211,357$20.3T1.01%
32
TNGXTango Therapeutics Inc
2,603,897$20.1T1.00%
33
SLDBSolid Biosciences Inc
2,749,041$19.2T0.96%
34
PRTAProthena Corporation PLC
1,099,840$18.4T0.92%
35
NAMSNewAmsterdam Pharma Company NV
920,564$15.3T0.76%
36
BHVNBiohaven Ltd
283,540$14.2T0.71%
37
KRROKorro Bio Inc
418,833$14.0T0.70%
38
APLTApplied Therapeutics Inc
1,633,768$13.9T0.69%
39
GOSSGossamer Bio Inc
13,488,610$13.3T0.67%Call
40
TILInstil Bio Inc
192,433$13.0T0.65%
41
EWTXEdgewise Therapeutics Inc
404,113$10.8T0.54%
42
IOVAIovance Biotherapeutics Inc
1,106,040$10.4T0.52%
43
ORICOric Pharmaceuticals Inc
1,007,575$10.3T0.52%
44
ISIIonis Pharmaceuticals Inc
250,000$10.0T0.50%
45
TSHATaysha Gene Therapies Inc
4,879,875$9.8T0.49%
46
MSFTMicrosoft Corp
22,000$9.5T0.47%
47
RNACCartesian Therapeutics Inc
572,236$9.2T0.46%
48
SLRNACELYRIN Inc
1,729,665$8.5T0.43%
49
PHATPhathom Pharmaceuticals Inc
460,753$8.3T0.42%
50
SEERSeer Inc
4,000,000$7.9T0.39%
51
RAPPRapport Therapeutics Inc
384,197$7.9T0.39%
52
NGNENeurogene Inc
175,898$7.4T0.37%
53
GBIOGBXGeneration Bio Co
2,982,733$7.4T0.37%
54
IHSIHS Holding Limited
2,357,520$7.0T0.35%
55
CRWDCrowdStrike Holdings Inc
25,000$7.0T0.35%
56
VIGLVigil Neuroscience Inc
1,991,038$6.8T0.34%
57
FHTXFoghorn Therapeutics Inc.
720,720$6.7T0.34%
58
NOWServiceNow Inc
7,500$6.7T0.34%
59
AMZNAmazon.com Inc
34,750$6.5T0.32%
60
BIOABIOAGE Labs Inc
300,000$6.2T0.31%
61
NVDANVIDIA Corp
48,932$5.9T0.30%
62
SYRSSyros Pharmaceuticals Inc
2,587,372$5.6T0.28%
63
NVCRNovocure Ltd
350,884$5.5T0.27%
64
LXEOLexeo Therapeutics Inc
603,435$5.5T0.27%
65
PDDPDD Holdings Inc
40,401$5.4T0.27%
66
Allovir Inc
6,597,167$5.3T0.27%
67
BDTXBlack Diamond Therapeutics Inc
1,046,517$4.6T0.23%
68
ANROAlto Neuroscience Inc
391,406$4.5T0.22%
69
DTDynatrace Inc
82,729$4.4T0.22%
70
IONQIONQ Inc
500,000$4.4T0.22%
71
TSMTaiwan Semiconductor Manufacturing Co Ltd
25,000$4.3T0.22%
72
AGENAgenus Inc
775,000$4.2T0.21%
73
DDOGDatadog Inc
32,925$3.8T0.19%
74
ADCTADC Therapeutics SA
1,163,461$3.7T0.18%
75
SESea Ltd
37,500$3.5T0.18%
76
OVIDOvid Therapeutics Inc
2,850,000$3.4T0.17%
77
PYPLPayPal Holdings Inc
41,000$3.2T0.16%Call
78
RGNXRegenxbio Inc
284,000$3.0T0.15%
79
N1UANew Oriental Education & Technology Group Inc
38,500$2.9T0.15%
80
QCOMQualcomm Inc
15,000$2.6T0.13%
81
HOOKHOOKIPA Pharma Inc
566,640$2.4T0.12%
82
TRMLTourmaline Bio Inc
91,426$2.4T0.12%
83
SGMTSagimet Biosciences Inc
724,771$2.0T0.10%
84
PCORProcore Technologies Inc
32,300$2.0T0.10%
85
BEKEKe Holdings Inc
100,000$2.0T0.10%
86
VVisa Inc
7,000$1.9T0.10%
87
2JQGritstone bio Inc
3,318,093$1.9T0.10%
88
GOOGLAlphabet Inc
11,000$1.8T0.09%
89
OXYOccidental Petroleum Corp
35,000$1.8T0.09%
90
FROGJfrog Ltd
61,000$1.8T0.09%
91
Omega Therapeutics Inc
1,323,530$1.6T0.08%
92
NTRANatera Inc
12,594$1.6T0.08%
93
PANWPalo Alto Networks Inc
4,500$1.5T0.08%
94
ESTCElastic NV
13,000$997.9B0.05%
95
INTCIntel Corp
40,000$938.4B0.05%
96
METAMeta Platforms Inc
1,500$858.7B0.04%
97
KRON1USDKronos Bio Inc
842,954$842.9B0.04%
98
TERNTerns Pharmaceuticals Inc
100,000$834.0B0.04%
99
RBRKRubrik Inc
25,000$803.8B0.04%
100
698Achilles Therapeutics PLC
755,375$770.5B0.04%
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