BAKER BROS. ADVISORS LP Q3 2022 Filing

Filed November 14, 2022

Portfolio Value

$15.3T

Holdings

115

Report Date

Q3 2022

Filing Type

13F-HR

All Holdings (115 positions)

#StockSharesValue% PortfolioType
1
SGENUSDSeagen Inc.
46,912,266$6.4T42.04%
2
INCYIncyte Corporation
36,154,574$2.4T15.78%
3
ONCBeiGene, Ltd.
11,668,897$1.6T10.30%
4
ACADACADIA Pharmaceuticals Inc.
41,923,486$685.9B4.49%
5
BMRNBioMarin Pharmaceutical Inc.
7,620,494$646.0B4.23%
6
ASNDAscendis Pharma A/S
4,852,655$501.1B3.28%
7
GBTUSDGlobal Blood Therapeutics, Inc.
3,732,502$254.2B1.66%
8
BCRXBioCryst Pharmaceuticals, Inc.
12,710,818$160.2B1.05%
9
RYTMRhythm Pharmaceuticals, Inc.
6,062,702$148.5B0.97%
10
KODKodiak Sciences Inc.
17,310,490$134.0B0.88%
11
IMCRImmunocore Holdings plc
2,520,731$118.3B0.77%
12
ABCLAbCellera Biologics Inc.
10,450,180$103.4B0.68%
13
ARGXargenx SE
280,159$98.9B0.65%
14
MRTXEURMirati Therapeutics, Inc.
1,409,784$98.5B0.64%
15
MDGLMadrigal Pharmaceuticals, Inc.
1,499,213$97.4B0.64%
16
CCXIEURChemoCentryx, Inc.
1,792,657$92.6B0.61%
17
TVTXTravere Therapeutics, Inc.
3,300,009$81.3B0.53%
18
AKROAkero Therapeutics, Inc.
2,368,378$80.6B0.53%
19
TRDAEntrada Therapeutics, Inc.
4,865,819$76.7B0.50%
20
1K0IGM Biosciences, Inc.
3,156,102$71.8B0.47%
21
REPLReplimune Group, Inc.
3,893,843$67.2B0.44%
22
PRLDPrelude Therapeutics Inc.
10,123,824$66.9B0.44%
23
KYMRKymera Therapeutics, Inc.
2,879,825$62.7B0.41%
24
HZNPHorizon Therapeutics Public Ltd Co
969,727$60.0B0.39%
25
CERSCerus Corporation
16,067,558$57.8B0.38%
26
NRIXNurix Therapeutics, Inc.
3,882,125$50.6B0.33%
27
290AChinook Therapeutics, Inc.
2,534,102$49.8B0.33%
28
VERVVerve Therapeutics, Inc.
1,416,530$48.7B0.32%
29
IMTXImmatics N.V.
4,423,731$44.2B0.29%
30
Forma Therapeutics Holdings, Inc.
1,886,760$37.6B0.25%
31
INSM 0.75 06/01/28Insmed Incorporated
40,000,000$36.3B0.24%
32
KNSAKiniksa Pharmaceuticals, Ltd.
2,799,577$35.9B0.24%
33
HRTXHeron Therapeutics, Inc.
8,131,678$34.3B0.22%
34
AVTEAerovate Therapeutics, Inc.
1,979,568$32.8B0.21%
35
TSVT*2seventy bio, Inc.
2,062,744$30.0B0.20%
36
KRYSKrystal Biotech, Inc.
422,185$29.4B0.19%
37
XENEXenon Pharmaceuticals Inc.
751,639$27.1B0.18%
38
CinCor Pharma, Inc.
807,212$26.5B0.17%
39
DBV Technologies S.A.
14,614,264$25.9B0.17%
40
IDYAIDEAYA Biosciences, Inc.
1,668,355$24.9B0.16%
41
DSGNDesign Therapeutics, Inc.
1,436,636$24.0B0.16%
42
VSTMVerastem, Inc.
26,988,898$22.9B0.15%
43
ALTAltimmune, Inc.
1,769,681$22.6B0.15%
44
NVTA1EURInvitae Corporation
8,402,035$20.7B0.14%
45
BMEABiomea Fusion, Inc.
2,104,559$20.6B0.13%
46
BCYCBicycle Therapeutics plc
843,814$19.6B0.13%
47
RAREUltragenyx Pharmaceutical Inc.
470,974$19.5B0.13%
48
TILInstil Bio, Inc.
3,893,700$18.8B0.12%
49
VERUEURVeru Inc.
1,609,579$18.5B0.12%
50
RLMDRelmada Therapeutics, Inc.
495,113$18.3B0.12%
51
ALKSAlkermes plc
815,016$18.2B0.12%
52
DNLIDenali Therapeutics Inc.
588,738$18.1B0.12%
53
OPTEYOpthea Limited
2,691,391$16.7B0.11%
54
bluebird bio, Inc.
2,499,715$15.8B0.10%
55
CRNXCrinetics Pharmaceuticals, Inc.
735,716$14.4B0.09%
56
WHWKAadi Bioscience, Inc.
989,928$14.0B0.09%
57
1T7Tricida, Inc.
1,320,290$13.8B0.09%
58
Affimed N.V.
6,596,830$13.6B0.09%
59
DICE Therapeutics, Inc.
588,235$11.9B0.08%
60
ANABAnaptysBio, Inc.
427,179$10.9B0.07%
61
FGENEURFibroGen, Inc.
815,718$10.6B0.07%
62
ADAPYAdaptimmune Therapeutics plc
9,830,877$10.6B0.07%
63
Zymeworks Inc.
1,708,472$10.5B0.07%
64
POINT Biopharma Global Inc.
1,169,103$9.0B0.06%
65
TCRXTScan Therapeutics, Inc.
2,784,792$8.5B0.06%
66
Invitae Corporation
10,300,000$8.1B0.05%
67
CBAYUSDCymaBay Therapeutics, Inc.
2,170,464$7.6B0.05%
68
VERAVera Therapeutics, Inc.
333,333$7.1B0.05%
69
PACBPacific Biosciences of California, Inc.
1,127,782$6.5B0.04%
70
FLGTFulgent Genetics, Inc.
166,619$6.4B0.04%
71
AMRNAmarin Corporation plc
5,377,113$5.9B0.04%
72
698Achilles Therapeutics plc
2,591,366$5.9B0.04%
73
VORVor Biopharma Inc.
1,465,925$5.8B0.04%
74
RETAEURReata Pharmaceuticals, Inc.
223,976$5.6B0.04%
75
BCELAtreca, Inc.
3,532,760$5.5B0.04%
76
NKTXNkarta, Inc.
400,000$5.3B0.03%
77
Talis Biomedical Corporation
7,624,835$5.2B0.03%
78
KRON1USDKronos Bio, Inc.
1,539,616$5.2B0.03%
79
CYTCyteir Therapeutics, Inc.
2,643,640$5.1B0.03%
80
SRZNSurrozen, Inc.
2,500,000$5.0B0.03%
81
EWTXEdgewise Therapeutics, Inc.
500,000$4.9B0.03%
82
FATEFate Therapeutics, Inc.
215,695$4.8B0.03%
83
STOKStoke Therapeutics, Inc.
369,327$4.7B0.03%
84
RVMDRevolution Medicines, Inc.
222,222$4.4B0.03%
85
NTRANatera, Inc.
100,000$4.4B0.03%
86
ALLKGUSDAllakos Inc.
703,050$4.3B0.03%
87
CLDNEUREiger BioPharmaceuticals, Inc.
539,851$4.1B0.03%
88
PMVPPMV Pharmaceuticals, Inc.
322,024$3.8B0.03%
89
IPSCCentury Therapeutics, Inc.
370,587$3.7B0.02%
90
HOOKGBPHOOKIPA Pharma Inc.
2,400,481$3.2B0.02%
91
Athira Pharma, Inc.
1,040,834$3.1B0.02%
92
MGNXMacroGenics, Inc.
892,579$3.1B0.02%
93
5E7iTeos Therapeutics, Inc.
150,346$2.9B0.02%
94
ATRAGBXAtara Biotherapeutics, Inc.
744,186$2.8B0.02%
95
TNGXTango Therapeutics, Inc.
750,000$2.7B0.02%
96
SNDXSyndax Pharmaceuticals, Inc.
110,729$2.7B0.02%
97
OTICEUROtonomy, Inc.
8,443,134$2.5B0.02%
98
Neoleukin Therapeutics, Inc.
3,821,740$2.4B0.02%
99
ALGSAligos Therapeutics, Inc.
2,076,400$2.3B0.01%
100
ALECAlector, Inc.
239,228$2.3B0.01%
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