RA CAPITAL MANAGEMENT, L.P.
CIK: 0001346824SEC EDGAR →
Portfolio Value
$9.8B
Holdings
71
As of
Q4 2025
New Positions
15
Closed Positions
11
Top 10 Holdings
| Rank | Stock | Shares | Value | % of Portfolio |
|---|---|---|---|---|
| 1 | ASCENDIS PHARMA A/S - ADR | 10,281,496 | $2.2B | 22.46% |
| 2 | CIDARA THERAPEUTICS INC | 3,365,523 | $743.4M | 7.62% |
| 3 | RHYTHM PHARMACEUTICALS INC | 6,666,837 | $713.6M | 7.31% |
| 4 | AVIDITY BIOSCIENCES INC | 8,641,031 | $623.3M | 6.39% |
| 5 | VAXCYTE INC | 10,724,599 | $494.8M | 5.07% |
| 6 | SIONNA THERAPEUTICS INC | 9,905,045 | $407.5M | 4.17% |
| 7 | NEWAMSTERDAM PHARMA CO NV | 9,550,191 | $335.0M | 3.43% |
| 8 | TYRA BIOSCIENCES INC | 12,198,625 | $320.7M | 3.29% |
| 9 | WAVE LIFE SCIENCES LTD | 18,203,009 | $309.5M | 3.17% |
| 10 | MINERALYS THERAPEUTICS INC | 7,323,750 | $265.8M | 2.72% |
Quarterly Changes
Top Buys
New Positions (22)
$123.5M · 15.8M shares
$110.2M · 374K shares
$65.0M · 2.6M shares
$59.2M · 3.5M shares
$53.1M · 1.6M shares
$49.6M · 5.0M shares
$43.5M · 1.5M shares
$36.7M · 428K shares
$24.9M · 1.9M shares
$21.7M · 9.2M shares
$17.5M · 10.7M shares
$16.7M · 7.1M shares
$15.3M · 8.0M shares
$14.1M · 335K shares
$11.5M · 8.5M shares
$8.0M · 948K shares
$4.7M · 144K shares
$3.7M · 80K shares
$2.1M · 44K shares
$2.0M · 110K shares
$1.9M · 794K shares
$1.1M · 70K shares
Closed Positions (18)
$292K · 19.9M shares
$43K · 1.2M shares
$42K · 1.5M shares
$35K · 676K shares
$27K · 1.1M shares
$20K · 6.0M shares
$17K · 2.0M shares
$17K · 3.0M shares
$15K · 1.1M shares
$12K · 200K shares
$9K · 3.6M shares
$8K · 2.7M shares
$8K · 603K shares
$6K · 7.5M shares
$5K · 579K shares
$4K · 54K shares
$3K · 55K shares
$3K · 2.0M shares
Sector Breakdown
| Sector | # Holdings | Value | % |
|---|---|---|---|
| Healthcare | 67 | $8.9B | 91.4% |
| Unknown | 2 | $827.6M | 8.5% |
| Financial Services | 1 | $9.8M | 0.1% |
| Technology | 1 | $4.7M | 0.0% |