BAKER BROS. ADVISORS LP Q2 2024 Filing

Filed August 14, 2024

Portfolio Value

$7825.1T

Holdings

95

Report Date

Q2 2024

Filing Type

13F-HR

All Holdings (95 positions)

#StockSharesValue% PortfolioType
1
INCYIncyte Corporation
30,738,524$1863.4T23.81%
2
ONCBeiGene, Ltd.
10,568,897$1507.9T19.27%
3
ACADACADIA Pharmaceuticals Inc.
42,877,916$696.8T8.90%
4
MDGLMadrigal Pharmaceuticals, Inc.
1,974,590$553.2T7.07%
5
RVMDRevolution Medicines, Inc.
7,569,090$293.8T3.75%
6
RYTMRhythm Pharmaceuticals, Inc.
6,398,365$262.7T3.36%
7
IM8NInsmed Incorporated
3,576,038$239.6T3.06%
8
BCYCBicycle Therapeutics plc
9,399,960$190.3T2.43%
9
SMMTSummit Therapeutics Inc.
23,222,222$181.1T2.31%
10
KYMRKymera Therapeutics, Inc.
5,995,928$179.0T2.29%
11
EWTXEdgewise Therapeutics, Inc.
5,840,059$105.2T1.34%
12
ALKSAlkermes plc
4,181,751$100.8T1.29%
13
INSM 0.75 06/01/28Insmed Incorporated
42,850,000$90.4T1.16%
14
REPLReplimune Group, Inc.
10,045,336$90.4T1.16%
15
DNLIDenali Therapeutics Inc.
3,731,695$86.6T1.11%
16
ABCLAbCellera Biologics Inc.
27,525,640$81.5T1.04%
17
NRIXNurix Therapeutics, Inc.
3,882,125$81.0T1.04%
18
IMTXImmatics N.V.
6,443,398$74.9T0.96%
19
TRDAEntrada Therapeutics, Inc.
4,865,819$69.3T0.89%
20
RAREUltragenyx Pharmaceutical Inc.
1,466,547$60.3T0.77%
21
STOKStoke Therapeutics, Inc.
4,368,443$59.0T0.75%
22
INSM 1.75 01/15/25Insmed Incorporated
32,887,000$56.2T0.72%
23
KNSAKiniksa Pharmaceuticals International, plc
2,818,323$52.6T0.67%
24
IMCRImmunocore Holdings plc
1,515,318$51.4T0.66%
25
ARGXargenx SE
111,904$48.1T0.61%
26
KODKodiak Sciences Inc.
17,310,490$40.7T0.52%
27
XENEXenon Pharmaceuticals Inc.
993,679$38.7T0.50%
28
PRLDPrelude Therapeutics Inc.
10,123,824$38.6T0.49%
29
IDYAIDEAYA Biosciences, Inc.
1,062,123$37.3T0.48%
30
CERSCerus Corporation
19,477,339$34.3T0.44%
31
SERASera Prognostics, Inc.
5,434,399$32.2T0.41%
32
KRYSKrystal Biotech, Inc.
169,934$31.2T0.40%
33
CELCCelcuity Inc.
1,874,978$30.7T0.39%
34
ROIVRoivant Sciences Ltd.
2,798,716$29.6T0.38%
35
1K0IGM Biosciences, Inc.
4,090,316$28.1T0.36%
36
CERE1EURCerevel Therapeutics Holdings, Inc.
683,588$28.0T0.36%
37
AKROAkero Therapeutics, Inc.
1,097,082$25.7T0.33%
38
DYNDyne Therapeutics, Inc.
672,096$23.7T0.30%
39
ALMSAlumis Inc.
1,562,500$20.8T0.27%
40
GLUEMonte Rosa Therapeutics, Inc.
4,916,095$18.4T0.23%
41
MRUSMerus N.V.
300,000$17.8T0.23%
42
NGNENeurogene Inc.
456,015$16.6T0.21%
43
TCRXTScan Therapeutics, Inc.
2,784,792$16.3T0.21%
44
SANASana Biotechnology, Inc.
2,380,949$13.0T0.17%
45
IMVTImmunovant, Inc.
464,718$12.3T0.16%
46
XNCRXencor, Inc.
545,431$10.3T0.13%
47
NMRANeumora Therapeutics, Inc.
1,034,600$10.2T0.13%
48
FATEFate Therapeutics, Inc.
2,997,772$9.8T0.13%
49
TSVT*2seventy bio, Inc.
2,497,526$9.6T0.12%
50
BMEABiomea Fusion, Inc.
2,108,949$9.5T0.12%
51
TCE2Celldex Therapeutics, Inc.
247,644$9.2T0.12%
52
TSHATaysha Gene Therapies, Inc.
4,004,756$9.0T0.11%
53
Athira Pharma, Inc.
3,153,807$8.4T0.11%
54
VERVVerve Therapeutics, Inc.
1,691,530$8.3T0.11%
55
RLAYRelay Therapeutics, Inc.
1,160,117$7.6T0.10%
56
MIRMMirum Pharmaceuticals, Inc.
190,476$6.5T0.08%
57
TNGXTango Therapeutics, Inc.
750,000$6.4T0.08%
58
KALAKALA BIO, Inc.
891,335$6.3T0.08%
59
DBVTDBV Technologies S.A.
7,307,131$5.9T0.07%
60
DSGNDesign Therapeutics, Inc.
1,695,294$5.7T0.07%
61
CTNMContineum Therapeutics, Inc.
312,500$5.5T0.07%
62
PRAXPraxis Precision Medicines, Inc.
131,533$5.4T0.07%
63
CRSPCRISPR Therapeutics AG
100,000$5.4T0.07%
64
PRMEPrime Medicine, Inc.
1,028,466$5.3T0.07%
65
CNTACentessa Pharmaceuticals plc
549,212$5.0T0.06%
66
HOOKHOOKIPA Pharma Inc.
8,128,151$4.8T0.06%
67
SGMTSagimet Biosciences Inc.
1,381,898$4.7T0.06%
68
CRNXCrinetics Pharmaceuticals, Inc.
103,927$4.7T0.06%
69
TLISTalis Biomedical Corporation
508,323$4.4T0.06%
70
ALECAlector, Inc.
927,264$4.2T0.05%
71
OPTEYOpthea Limited
2,173,622$4.2T0.05%
72
SKYESkye Bioscience, Inc.
500,000$4.0T0.05%
73
PCVXVaxcyte, Inc.
48,885$3.7T0.05%
74
ARCTArcturus Therapeutics Holdings Inc.
151,329$3.7T0.05%
75
GBIOGBXGeneration Bio Co.
1,206,957$3.4T0.04%
76
ELVNEnliven Therapeutics, Inc.
114,833$2.7T0.03%
77
CYPHLeap Therapeutics, Inc.
1,172,175$2.3T0.03%
78
ADAPYAdaptimmune Therapeutics plc
2,343,695$2.3T0.03%
79
Mersana Therapeutics, Inc.
1,086,115$2.2T0.03%
80
IPSCCentury Therapeutics, Inc.
797,460$2.0T0.03%
81
NAMSNewAmsterdam Pharma Company N.V.
96,827$1.9T0.02%
82
SG7Sage Therapeutics, Inc.
171,026$1.9T0.02%
83
VTVTvTv Therapeutics, Inc.
97,314$1.7T0.02%
84
CMPXCompass Therapeutics, Inc.
1,557,630$1.6T0.02%
85
TARAProtara Therapeutics, Inc.
536,832$1.1T0.01%
86
AVTEAerovate Therapeutics, Inc.
628,939$1.0T0.01%
87
PFEPfizer Inc.
35,000$979.3B0.01%
88
698Achilles Therapeutics plc
1,108,767$903.6B0.01%
89
ALGSAligos Therapeutics, Inc.
2,076,400$726.7B0.01%
90
PMVPPMV Pharmaceuticals, Inc.
322,024$521.7B0.01%
91
BCRXBioCryst Pharmaceuticals, Inc.
75,778$468.3B0.01%
92
ACRVAcrivon Therapeutics, Inc.
52,885$306.7B0.00%
93
FHTXFoghorn Therapeutics Inc.
45,027$258.9B0.00%
94
TYRATyra Biosciences, Inc.
10,607$169.6B0.00%
95
SRZNWSurrozen, Inc.
833,333$13.8B0.00%