BAKER BROS. ADVISORS LP Q4 2022 Filing

Filed February 14, 2023

Portfolio Value

$16651.4T

Holdings

113

Report Date

Q4 2022

Filing Type

13F-HR

All Holdings (113 positions)

#StockSharesValue% PortfolioType
1
SGENUSDSeagen Inc.
46,912,266$6028.7T36.21%
2
INCYIncyte Corporation
36,154,971$2904.0T17.44%
3
ONCBeiGene, Ltd.
11,668,897$2566.5T15.41%
4
BMRNBioMarin Pharmaceutical Inc.
7,620,494$788.6T4.74%
5
ACADACADIA Pharmaceuticals Inc.
41,923,486$667.4T4.01%
6
ASNDAscendis Pharma A/S
4,954,855$605.1T3.63%
7
MDGLMadrigal Pharmaceuticals, Inc.
1,545,113$448.5T2.69%
8
RYTMRhythm Pharmaceuticals, Inc.
6,354,608$185.0T1.11%
9
BCRXBioCryst Pharmaceuticals, Inc.
12,710,818$145.9T0.88%
10
IMCRImmunocore Holdings plc
2,520,731$143.9T0.86%
11
AKROAkero Therapeutics, Inc.
2,368,378$129.8T0.78%
12
REPLReplimune Group, Inc.
4,578,280$124.5T0.75%
13
KODKodiak Sciences Inc.
17,310,490$123.9T0.74%
14
HZNPHorizon Therapeutics Public Ltd Co
969,727$110.4T0.66%
15
ARGXargenx SE
280,159$106.1T0.64%
16
ABCLAbCellera Biologics Inc.
10,450,180$105.9T0.64%
17
KYMRKymera Therapeutics, Inc.
2,879,825$71.9T0.43%
18
290AChinook Therapeutics, Inc.
2,534,102$66.4T0.40%
19
TRDAEntrada Therapeutics, Inc.
4,865,819$65.8T0.40%
20
MRTXEURMirati Therapeutics, Inc.
1,409,784$63.9T0.38%
21
PRLDPrelude Therapeutics Inc.
10,123,824$61.1T0.37%
22
CERSCerus Corporation
16,067,558$58.6T0.35%
23
AVTEAerovate Therapeutics, Inc.
1,976,868$57.9T0.35%
24
1K0IGM Biosciences, Inc.
3,156,102$53.7T0.32%
25
IMTXImmatics N.V.
5,187,081$45.2T0.27%
26
NRIXNurix Therapeutics, Inc.
3,882,125$42.6T0.26%
27
KNSAKiniksa Pharmaceuticals, Ltd.
2,799,577$41.9T0.25%
28
SWTXSpringWorks Therapeutics, Inc.
1,528,538$39.8T0.24%
29
IDYAIDEAYA Biosciences, Inc.
1,668,355$30.3T0.18%
30
DNLIDenali Therapeutics Inc.
1,088,738$30.3T0.18%
31
XENEXenon Pharmaceuticals Inc.
751,639$29.6T0.18%
32
VERVVerve Therapeutics, Inc.
1,416,530$27.4T0.16%
33
DICE Therapeutics, Inc.
862,207$26.9T0.16%
34
TVTXTravere Therapeutics, Inc.
1,225,255$25.8T0.15%
35
BCYCBicycle Therapeutics plc
843,814$25.0T0.15%
36
ANABAnaptysBio, Inc.
775,924$24.0T0.14%
37
KRYSKrystal Biotech, Inc.
302,716$24.0T0.14%
38
DBV Technologies S.A.
14,614,264$22.4T0.13%
39
FGENEURFibroGen, Inc.
1,375,211$22.0T0.13%
40
RAREUltragenyx Pharmaceutical Inc.
470,974$21.8T0.13%
41
HRTXHeron Therapeutics, Inc.
8,131,678$20.3T0.12%
42
TSVT*2seventy bio, Inc.
2,062,744$19.3T0.12%
43
INSM 0.75 06/01/28Insmed Incorporated
23,500,000$19.2T0.12%
44
PRMEPrime Medicine, Inc.
1,028,466$19.1T0.11%
45
BMEABiomea Fusion, Inc.
2,104,559$17.7T0.11%
46
bluebird bio, Inc.
2,499,715$17.3T0.10%
47
SPRYARS Pharmaceuticals, Inc.
2,006,451$17.1T0.10%
48
NVTA1EURInvitae Corporation
8,402,035$15.6T0.09%
49
OPTEYOpthea Limited
2,691,391$14.4T0.09%
50
ADAPYAdaptimmune Therapeutics plc
9,830,877$14.4T0.09%
51
CBAYUSDCymaBay Therapeutics, Inc.
2,170,464$13.6T0.08%
52
ZYMEZymeworks Inc.
1,708,472$13.4T0.08%
53
WHWKAadi Bioscience, Inc.
989,928$12.7T0.08%
54
CABACabaletta Bio, Inc.
1,344,000$12.4T0.07%
55
VSTMVerastem, Inc.
26,988,898$10.9T0.07%
56
ALTAltimmune, Inc.
653,562$10.8T0.06%
57
STOKStoke Therapeutics, Inc.
1,108,913$10.2T0.06%
58
CinCor Pharma, Inc.
807,212$9.9T0.06%
59
VORVor Biopharma Inc.
1,465,925$9.7T0.06%
60
RNAAvidity Biosciences, Inc.
434,782$9.6T0.06%
61
PACBPacific Biosciences of California, Inc.
1,127,782$9.2T0.06%
62
POINT Biopharma Global Inc.
1,169,103$8.5T0.05%
63
RETAEURReata Pharmaceuticals, Inc.
223,976$8.5T0.05%
64
SMMTSummit Therapeutics Inc.
2,000,000$8.5T0.05%
65
VERUEURVeru Inc.
1,609,579$8.5T0.05%
66
Affimed N.V.
6,596,830$8.2T0.05%
67
Invitae Corporation
10,300,000$8.1T0.05%
68
CMPXCompass Therapeutics, Inc.
1,557,630$7.8T0.05%
69
DSGNDesign Therapeutics, Inc.
692,131$7.1T0.04%
70
BHVNBiohaven Ltd.
476,190$6.6T0.04%
71
VERAVera Therapeutics, Inc.
333,333$6.4T0.04%
72
ALECAlector, Inc.
681,991$6.3T0.04%
73
MGNXMacroGenics, Inc.
892,579$6.0T0.04%
74
Athira Pharma, Inc.
1,879,836$6.0T0.04%
75
IPSCCentury Therapeutics, Inc.
1,149,340$5.9T0.04%
76
ROIVRoivant Sciences Ltd.
716,653$5.7T0.03%
77
TNGXTango Therapeutics, Inc.
750,000$5.4T0.03%
78
RVMDRevolution Medicines, Inc.
222,222$5.3T0.03%
79
EWTXEdgewise Therapeutics, Inc.
500,000$4.5T0.03%
80
PRAXPraxis Precision Medicines, Inc.
1,830,315$4.4T0.03%
81
TCRXTScan Therapeutics, Inc.
2,784,792$4.3T0.03%
82
VSAREURAravive, Inc.
3,261,224$4.3T0.03%
83
CYTCyteir Therapeutics, Inc.
2,492,118$4.1T0.02%
84
NTRANatera, Inc.
100,000$4.0T0.02%
85
Talis Biomedical Corporation
7,624,835$3.4T0.02%
86
TILInstil Bio, Inc.
5,273,789$3.3T0.02%
87
XNCRXencor, Inc.
123,127$3.2T0.02%
88
5E7iTeos Therapeutics, Inc.
150,346$2.9T0.02%
89
KALAKala Pharmaceuticals, Inc.
76,813$2.9T0.02%
90
BCELAtreca, Inc.
3,532,760$2.8T0.02%
91
HOOKGBPHOOKIPA Pharma Inc.
3,475,535$2.8T0.02%
92
PMVPPMV Pharmaceuticals, Inc.
322,024$2.8T0.02%
93
ATRAGBXAtara Biotherapeutics, Inc.
744,186$2.4T0.01%
94
NKTXNkarta, Inc.
400,000$2.4T0.01%
95
PCVXVaxcyte, Inc.
48,885$2.3T0.01%
96
698Achilles Therapeutics plc
2,591,366$2.3T0.01%
97
FATEFate Therapeutics, Inc.
215,695$2.2T0.01%
98
ALGSAligos Therapeutics, Inc.
2,076,400$2.0T0.01%
99
Neoleukin Therapeutics, Inc.
3,821,740$1.9T0.01%
100
KRON1USDKronos Bio, Inc.
1,198,151$1.9T0.01%
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