ORBIMED ADVISORS LLC Q1 2022 Filing
Filed May 16, 2022
Portfolio Value
$6.2B
Holdings
141
Report Date
Q1 2022
Filing Type
13F-HR
All Holdings (141 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | SWTXSPRINGWORKS THERAPEUTICS INC | 6,028,307 | $340.2B | 5516.84% | |
| 2 | HZNPHORIZON THERAPEUTICS PUB L | 2,196,555 | $231.1B | 3747.21% | |
| 3 | BSXBOSTON SCIENTIFIC CORP | 4,599,500 | $203.7B | 3303.12% | |
| 4 | PFEPFIZER INC | 3,905,500 | $202.2B | 3278.41% | |
| 5 | —THESEUS PHARMACEUTICALS INC | 17,041,668 | $196.5B | 3186.02% | |
| 6 | BMYBRISTOL-MYERS SQUIBB CO | 2,607,700 | $190.4B | 3087.92% | |
| 7 | HUMHUMANA INC | 381,700 | $166.1B | 2693.32% | |
| 8 | ISRGINTUITIVE SURGICAL INC | 534,200 | $161.2B | 2613.10% | |
| 9 | UNHUNITEDHEALTH GROUP INC | 294,200 | $150.0B | 2432.73% | |
| 10 | TORCEURADICET BIO INC | 7,447,141 | $148.7B | 2411.43% | |
| 11 | ABBVABBVIE INC | 915,600 | $148.4B | 2406.71% | |
| 12 | PMVPPMV PHARMACEUTICALS INC | 6,855,423 | $142.7B | 2314.32% | |
| 13 | EWTXEDGEWISE THERAPEUTICS INC | 13,944,680 | $135.3B | 2193.24% | |
| 14 | MRTXEURMIRATI THERAPEUTICS INC | 1,630,500 | $134.1B | 2173.74% | |
| 15 | BMRNBIOMARIN PHARMACEUTICAL INC | 1,647,030 | $127.0B | 2059.03% | |
| 16 | EWEDWARDS LIFESCIENCES CORP | 1,051,300 | $123.8B | 2006.71% | |
| 17 | SYKSTRYKER CORPORATION | 457,100 | $122.2B | 1981.53% | |
| 18 | ARQTARCUTIS BIOTHERAPEUTICS INC | 6,073,850 | $117.0B | 1896.82% | |
| 19 | IOVAIOVANCE BIOTHERAPEUTICS INC | 6,633,006 | $110.4B | 1790.75% | |
| 20 | VRTXVERTEX PHARMACEUTICALS INC | 400,200 | $104.4B | 1693.46% | |
| 21 | SGENUSDSEAGEN INC | 667,700 | $96.2B | 1559.56% | |
| 22 | KROSKEROS THERAPEUTICS INC | 1,679,417 | $91.3B | 1480.84% | |
| 23 | GHGUARDANT HEALTH INC | 1,325,400 | $87.8B | 1423.55% | |
| 24 | —BIOHAVEN PHARMACTL HLDG CO L | 719,034 | $85.3B | 1382.40% | |
| 25 | 1T7TRICIDA INC | 10,280,947 | $84.5B | 1370.28% | |
| 26 | NBIXNEUROCRINE BIOSCIENCES INC | 875,515 | $82.1B | 1330.90% | |
| 27 | DC4DEXCOM INC | 149,900 | $76.7B | 1243.49% | |
| 28 | TMOTHERMO FISHER SCIENTIFIC INC | 120,600 | $71.2B | 1155.00% | |
| 29 | NTRANATERA INC | 1,745,385 | $71.0B | 1151.27% | Call |
| 30 | SIBNSI-BONE INC | 3,139,247 | $70.9B | 1150.38% | |
| 31 | CRNXCRINETICS PHARMACEUTICALS IN | 3,196,876 | $70.2B | 1137.80% | |
| 32 | PRLDPRELUDE THERAPEUTICS INC | 10,039,691 | $69.3B | 1123.25% | |
| 33 | —SIERRA ONCOLOGY INC | 1,964,770 | $63.0B | 1021.05% | |
| 34 | GBTUSDGLOBAL BLOOD THERAPEUTICS IN | 1,626,600 | $56.3B | 913.61% | Call |
| 35 | —TURNING POINT THERAPEUTICS I | 2,018,950 | $54.2B | 878.98% | |
| 36 | THCTENET HEALTHCARE CORP | 628,300 | $54.0B | 875.74% | |
| 37 | ARGXARGENX SE | 169,800 | $53.5B | 868.13% | |
| 38 | XTNTXTANT MED HLDGS INC | 72,943,918 | $49.6B | 804.28% | |
| 39 | RPTXREPARE THERAPEUTICS INC | 3,322,488 | $47.3B | 767.15% | |
| 40 | MGTXMEIRAGTX HLDGS PLC | 3,296,666 | $45.7B | 740.34% | |
| 41 | —KINNATE BIOPHARMA INC | 4,043,629 | $45.5B | 738.27% | |
| 42 | EVHEVOLENT HEALTH INC | 1,400,000 | $45.2B | 733.23% | |
| 43 | ABCLABCELLERA BIOLOGICS INC | 4,180,768 | $40.8B | 660.94% | |
| 44 | JANXJANUX THERAPEUTICS INC | 2,836,386 | $40.7B | 659.51% | |
| 45 | NSTGEURNANOSTRING TECHNOLOGIES INC | 1,157,387 | $40.2B | 652.14% | |
| 46 | IMAPRELUDE THERAPEUTICS INC | 5,680,186 | $39.2B | 635.50% | |
| 47 | IMAIKENA ONCOLOGY INC | 6,215,466 | $37.9B | 614.76% | |
| 48 | SNDXSYNDAX PHARMACEUTICALS INC | 2,158,300 | $37.5B | 608.23% | |
| 49 | NVLSEURALPINE IMMUNE SCIENCES INC | 4,081,592 | $36.6B | 593.65% | |
| 50 | PCVXVAXCYTE INC | 1,513,659 | $36.6B | 592.73% | |
| 51 | TELATELA BIO INC | 3,027,542 | $35.2B | 570.92% | |
| 52 | NPCENEUROPACE INC | 4,012,281 | $32.9B | 534.13% | |
| 53 | TBPHTHERAVANCE BIOPHARMA INC | 3,254,713 | $31.1B | 504.52% | |
| 54 | SPRYSILVERBACK THERAPEUTICS INC | 8,740,887 | $30.7B | 497.48% | |
| 55 | CMPXCOMPASS THERAPEUTICS INC | 21,642,975 | $29.7B | 480.78% | |
| 56 | VRNAVERONA PHARMA PLC | 5,694,841 | $28.4B | 460.77% | |
| 57 | SCPHSCPHARMACEUTICALS INC | 4,797,148 | $27.2B | 441.82% | |
| 58 | ACRSACLARIS THERAPEUTICS INC | 1,579,900 | $27.2B | 441.64% | |
| 59 | GHRSGH RESEARCH PLC | 1,428,732 | $26.1B | 423.72% | |
| 60 | —VECTIVBIO HLDG AG | 5,330,704 | $25.1B | 407.12% | |
| 61 | —FUSION PHARMACEUTICALS INC | 3,224,770 | $25.1B | 406.27% | |
| 62 | BIIBBIOGEN INC | 117,900 | $24.8B | 402.61% | |
| 63 | 290ACHINOOK THERAPEUTICS INC | 1,418,300 | $23.2B | 376.23% | |
| 64 | IVVDADAGIO THERAPEUTICS INC | 5,056,000 | $23.1B | 373.83% | |
| 65 | PASGPASSAGE BIO INC | 7,331,999 | $22.7B | 368.54% | |
| 66 | XENEXENON PHARMACEUTICALS INC | 686,000 | $21.0B | 340.04% | |
| 67 | JNCEEURJOUNCE THERAPEUTICS INC | 2,859,900 | $19.4B | 314.87% | |
| 68 | MREOMEREO BIOPHARMA GROUP PLC | 17,264,764 | $19.3B | 313.53% | |
| 69 | —MERSANA THERAPEUTICS INC | 4,788,900 | $19.1B | 309.83% | |
| 70 | GRCLGRACELL BIOTECHNOLOGIES INC | 7,884,870 | $18.4B | 297.90% | |
| 71 | —IKENA ONCOLOGY INC | 2,933,941 | $17.9B | 290.19% | |
| 72 | VTYXVENTYX BIOSCIENCES INC | 1,289,280 | $17.5B | 283.69% | |
| 73 | RXSTRXSIGHT INC | 1,383,500 | $17.1B | 277.72% | |
| 74 | GILDGILEAD SCIENCES INC | 287,600 | $17.1B | 277.24% | |
| 75 | QUREUNIQURE NV | 919,249 | $16.6B | 269.34% | |
| 76 | MISTMILESTONE PHARMACEUTICALS IN | 2,583,821 | $16.6B | 268.97% | |
| 77 | RAREULTRAGENYX PHARMACEUTICAL IN | 227,600 | $16.5B | 268.00% | |
| 78 | VTGNUSDVISTAGEN THERAPEUTICS INC | 12,909,283 | $16.0B | 259.56% | |
| 79 | ILMNILLUMINA INC | 45,100 | $15.8B | 255.51% | |
| 80 | —HARPOON THERAPEUTICS INC | 3,039,508 | $15.1B | 244.94% | |
| 81 | —DECIBEL THERAPEUTICS INC | 4,945,192 | $15.0B | 243.75% | |
| 82 | —SINGULAR GENOMICS SYSTEMS IN | 2,300,792 | $14.5B | 235.40% | |
| 83 | —SYNLOGIC INC | 6,029,995 | $14.5B | 234.66% | |
| 84 | BBIO 2.25 02/01/29BRIDGEBIO PHARMA INC | 30,000,000 | $14.4B | 233.75% | |
| 85 | ERASERASCA INC | 1,667,693 | $14.3B | 232.55% | |
| 86 | TCE2CELLDEX THERAPEUTICS INC NEW | 406,100 | $13.8B | 224.28% | |
| 87 | AMGNAMGEN INC | 57,100 | $13.8B | 223.89% | |
| 88 | ETNBGBP89BIO INC | 3,658,869 | $13.8B | 223.66% | |
| 89 | BNRBURNING ROCK BIOTECH LTD | 1,452,402 | $13.5B | 218.78% | |
| 90 | NXTCNEXTCURE INC | 2,711,013 | $13.2B | 213.64% | |
| 91 | GLPGGALAPAGOS NV | 208,225 | $12.9B | 209.40% | |
| 92 | DHR 5 04/15/23 BDANAHER CORPORATION | 8,039 | $12.7B | 205.86% | |
| 93 | CMMBCHEMOMAB THERAPEUTICS LTD | 2,578,174 | $12.4B | 200.66% | |
| 94 | BBIO 2.5 03/15/27BRIDGEBIO PHARMA INC | 20,000,000 | $12.0B | 194.58% | |
| 95 | CRVSCORVUS PHARMACEUTICALS INC | 6,943,654 | $11.4B | 184.65% | |
| 96 | SGFYGBPSIGNIFY HEALTH INC | 620,700 | $11.3B | 182.67% | |
| 97 | TERNTERNS PHARMACEUTICALS INC | 3,791,204 | $11.3B | 182.58% | |
| 98 | ORICORIC PHARMACEUTICALS INC | 2,087,568 | $11.1B | 180.76% | |
| 99 | LUNGPULMONX CORP | 435,000 | $10.8B | 174.99% | |
| 100 | ALXOALX ONCOLOGY HLDGS INC | 621,700 | $10.5B | 170.37% |
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