RTW INVESTMENTS, LP Q3 2025 Filing
Filed November 14, 2025
Portfolio Value
$8.1B
Holdings
74
Report Date
Q3 2025
Filing Type
13F-HR
All Holdings (74 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | MDGLMADRIGAL PHARMACEUTICALS INC | 1,993,687 | $914.4B | 11266.74% | |
| 2 | ARGXARGENX SE | 673,497 | $496.7B | 6120.45% | |
| 3 | RNAAVIDITY BIOSCIENCES INC | 11,372,829 | $495.5B | 6105.29% | |
| 4 | PTCTPTC THERAPEUTICS INC | 7,746,415 | $475.4B | 5857.43% | |
| 5 | IM8NINSMED INC | 3,084,558 | $444.2B | 5473.13% | |
| 6 | PTGXPROTAGONIST THERAPEUTICS INC | 5,756,277 | $382.4B | 4711.47% | |
| 7 | NTRANATERA INC | 2,000,000 | $321.9B | 3966.66% | |
| 8 | AKROAKERO THERAPEUTICS INC | 5,477,561 | $260.1B | 3204.41% | |
| 9 | QUREUNIQURE NV | 4,424,968 | $258.3B | 3182.37% | |
| 10 | PENPENUMBRA INC | 866,499 | $219.5B | 2704.51% | |
| 11 | RDNTRADNET INC | 2,815,544 | $214.6B | 2643.78% | |
| 12 | MRUSMERUS N V | 2,025,277 | $190.7B | 2349.39% | |
| 13 | TARSTARSUS PHARMACEUTICALS INC | 3,177,436 | $188.8B | 2326.66% | |
| 14 | SYKSTRYKER CORPORATION | 490,000 | $181.1B | 2231.83% | |
| 15 | IMCRIMMUNOCORE HLDGS PLC | 4,869,798 | $176.9B | 2179.85% | |
| 16 | ACADACADIA PHARMACEUTICALS INC | 7,144,524 | $152.5B | 1878.53% | |
| 17 | CYTKCYTOKINETICS INC | 2,721,158 | $149.6B | 1842.68% | |
| 18 | NBIXNEUROCRINE BIOSCIENCES INC | 1,062,072 | $149.1B | 1837.00% | |
| 19 | AXSMAXSOME THERAPEUTICS INC | 1,118,883 | $135.9B | 1674.30% | |
| 20 | STOKSTOKE THERAPEUTICS INC | 5,123,525 | $120.4B | 1483.50% | |
| 21 | APGEAPOGEE THERAPEUTICS INC | 2,712,097 | $107.8B | 1327.62% | |
| 22 | ESTAESTABLISHMENT LABS HLDGS INC | 2,588,831 | $106.1B | 1307.47% | |
| 23 | 3M4MASIMO CORP | 683,294 | $100.8B | 1242.22% | |
| 24 | RAREULTRAGENYX PHARMACEUTICAL IN | 3,258,266 | $98.0B | 1207.58% | |
| 25 | GHGUARDANT HEALTH INC | 1,481,033 | $92.5B | 1140.14% | |
| 26 | URGNUROGEN PHARMA LTD | 4,543,895 | $90.7B | 1116.92% | |
| 27 | ISRGINTUITIVE SURGICAL INC | 202,456 | $90.5B | 1115.61% | |
| 28 | GHRSGH RESEARCH PLC | 5,569,564 | $79.6B | 981.31% | |
| 29 | TSHATAYSHA GENE THERAPIES INC | 24,354,291 | $79.6B | 981.24% | |
| 30 | ZLABZAI LAB LTD | 2,291,372 | $77.7B | 956.79% | |
| 31 | IMTXIMMATICS N.V | 8,815,617 | $75.1B | 925.43% | |
| 32 | XNCRXENCOR INC | 6,221,054 | $73.0B | 899.11% | |
| 33 | CGONCG ONCOLOGY INC | 1,701,216 | $68.5B | 844.31% | |
| 34 | BBNXBETA BIONICS INC | 3,299,191 | $65.6B | 807.71% | |
| 35 | SYRESPYRE THERAPEUTICS INC | 3,621,996 | $60.7B | 747.95% | |
| 36 | RCKTROCKET PHARMACEUTICALS INC | 17,687,772 | $57.7B | 710.46% | |
| 37 | CNTACENTESSA PHARMACEUTICALS PLC | 2,291,747 | $55.6B | 684.75% | |
| 38 | ALKSALKERMES PLC | 1,672,356 | $50.2B | 618.16% | |
| 39 | CMPSCOMPASS PATHWAYS PLC | 8,707,390 | $49.9B | 614.74% | |
| 40 | COGTCOGENT BIOSCIENCES INC | 3,467,486 | $49.8B | 613.51% | |
| 41 | VSTMVERASTEM INC | 5,426,306 | $47.9B | 590.36% | |
| 42 | DGXQUEST DIAGNOSTICS INC | 250,000 | $47.6B | 587.04% | |
| 43 | LENZLENZ THERAPEUTICS INC | 863,389 | $40.2B | 495.51% | |
| 44 | RAPTRAPT THERAPEUTICS INC | 1,470,499 | $37.9B | 467.27% | |
| 45 | ORKAORUKA THERAPEUTICS INC | 1,945,649 | $37.4B | 460.99% | |
| 46 | DYNDYNE THERAPEUTICS INC | 2,890,567 | $36.6B | 450.53% | |
| 47 | CRNXCRINETICS PHARMACEUTICALS IN | 872,387 | $36.3B | 447.69% | |
| 48 | AQSTAQUESTIVE THERAPEUTICS INC | 6,250,000 | $34.9B | 430.47% | |
| 49 | ABVXABIVAX SA | 350,000 | $29.7B | 366.12% | |
| 50 | GEHCGE HEALTHCARE TECHNOLOGIES I | 393,500 | $29.6B | 364.11% | |
| 51 | REPLREPLIMUNE GROUP INC | 6,395,732 | $26.8B | 330.18% | |
| 52 | NGNENEUROGENE INC | 1,362,456 | $23.6B | 290.92% | |
| 53 | BLTEBELITE BIO INC | 312,500 | $23.1B | 284.93% | |
| 54 | ALECALECTOR INC | 6,990,806 | $20.7B | 254.96% | |
| 55 | OBIOORCHESTRA BIOMED HLDGS INC | 8,306,063 | $20.6B | 253.80% | |
| 56 | CRVSCORVUS PHARMACEUTICALS INC | 2,679,479 | $19.7B | 243.31% | |
| 57 | XGNEXAGEN INC | 1,696,866 | $18.6B | 229.77% | |
| 58 | HTFLHEARTFLOW INC | 495,000 | $16.7B | 205.29% | |
| 59 | TEMTEMPUS AI INC | 200,000 | $16.1B | 198.89% | |
| 60 | JBIOJADE BIOSCIENCES INC | 1,449,273 | $12.5B | 154.10% | |
| 61 | CTMXCYTOMX THERAPEUTICS INC | 3,461,500 | $11.0B | 136.05% | |
| 62 | CGEMCULLINAN THERAPEUTICS INC | 1,705,960 | $10.1B | 124.64% | |
| 63 | LRMRLARIMAR THERAPEUTICS INC | 3,125,000 | $10.1B | 124.37% | |
| 64 | CMPXCOMPASS THERAPEUTICS INC | 2,500,000 | $8.8B | 107.81% | |
| 65 | —PERCEPTIVE CAP SOLUTIONS COR | 742,500 | $7.8B | 96.61% | |
| 66 | PEPGPEPGEN INC | 1,500,000 | $6.9B | 85.39% | |
| 67 | WVEWAVE LIFE SCIENCES LTD | 900,000 | $6.6B | 81.17% | |
| 68 | ALURALLURION TECHNOLOGIES INC | 2,542,603 | $5.2B | 64.22% | |
| 69 | MISTMILESTONE PHARMACEUTICALS IN | 2,506,102 | $5.0B | 61.76% | |
| 70 | OMDAOMADA HEALTH INC | 200,000 | $4.4B | 54.48% | |
| 71 | TENXTENAX THERAPEUTICS INC | 378,346 | $2.9B | 35.48% | |
| 72 | IMAIMAGENEBIO INC | 334,445 | $2.7B | 33.58% | |
| 73 | ADGMADAGIO MED HLDGS INC | 209,361 | $406.2M | 5.00% | |
| 74 | RCKTWROCKET PHARMACEUTICALS INC | 350,000 | $13.7M | 0.17% |