Affinity Asset Advisors, LLC Q3 2025 Filing

Filed November 13, 2025

Portfolio Value

$1.1T

Holdings

93

Report Date

Q3 2025

Filing Type

13F-HR

All Holdings (93 positions)

#StockSharesValue% PortfolioType
1
IM8NINSMED INC
655,000$94.3B8.22%Call
2
VRNAVERONA PHARMA PLC
625,000$66.7B5.81%
3
SPYSPDR S&P 500 ETF TR
84,490$56.3B4.90%
4
XENEXENON PHARMACEUTICALS INC
1,400,000$56.2B4.90%
5
MDGLMADRIGAL PHARMACEUTICALS INC
115,000$52.7B4.59%
6
APGEAPOGEE THERAPEUTICS INC
1,173,426$46.6B4.06%
7
ACLXARCELLX INC
500,000$41.0B3.58%
8
ALKSALKERMES PLC
1,250,000$37.5B3.27%
9
NUVLNUVALENT INC
384,417$33.2B2.90%
10
ABVXABIVAX SA
360,000$30.6B2.66%
11
MLYSMINERALYS THERAPEUTICS INC
750,000$28.4B2.48%
12
TEVATEVA PHARMACEUTICAL INDS LTD
1,400,000$28.3B2.46%
13
MRUSMERUS N V
285,769$26.9B2.34%
14
CNTACENTESSA PHARMACEUTICALS PLC
1,107,162$26.8B2.34%
15
LXEOLEXEO THERAPEUTICS INC
3,870,527$25.7B2.24%
16
TRVITREVI THERAPEUTICS INC
2,800,000$25.6B2.23%
17
SYRESPYRE THERAPEUTICS INC
1,419,299$23.8B2.07%
18
EX9EXELIXIS INC
500,000$20.6B1.80%Put
19
RZLTREZOLUTE INC
2,100,000$19.7B1.72%
20
CYTKCYTOKINETICS INC
350,000$19.2B1.68%
21
ORKAORUKA THERAPEUTICS INC
959,180$18.4B1.61%
22
QUREUNIQURE NV
300,000$17.5B1.53%
23
WVEWAVE LIFE SCIENCES LTD
2,100,000$15.4B1.34%
24
PTGXPROTAGONIST THERAPEUTICS INC
220,600$14.7B1.28%
25
SLNOSOLENO THERAPEUTICS INC
200,000$13.5B1.18%
26
AVTXAVALO THERAPEUTICS INC
1,006,217$12.8B1.11%
27
ESTAESTABLISHMENT LABS HLDGS INC
310,000$12.7B1.11%
28
KPTI 3 10/15/25KARYOPHARM THERAPEUTICS INC
15,250,000$12.5B1.09%
29
VTYXVENTYX BIOSCIENCES INC
3,924,415$12.2B1.06%
30
ROIVROIVANT SCIENCES LTD
800,000$12.1B1.05%
31
TVTXTRAVERE THERAPEUTICS INC
500,000$11.9B1.04%
32
DNTHDIANTHUS THERAPEUTICS INC
262,100$10.3B0.90%
33
TSHATAYSHA GENE THERAPIES INC
3,000,000$9.8B0.85%
34
ERASERASCA INC
4,285,787$9.3B0.81%
35
NRIXNURIX THERAPEUTICS INC
967,620$8.9B0.78%
36
VERAVERA THERAPEUTICS INC
303,330$8.8B0.77%
37
ELVNENLIVEN THERAPEUTICS INC
400,000$8.2B0.71%
38
TVTX 2.25 03/01/29TRAVERE THERAPEUTICS INC
7,000,000$7.9B0.69%
39
NAMSNEWAMSTERDAM PHARMA COMPANY
275,000$7.8B0.68%
40
TCE2CELLDEX THERAPEUTICS INC NEW
300,000$7.8B0.68%
41
PRQRPROQR THRAPEUTICS N V
3,600,000$7.7B0.67%
42
TARSTARSUS PHARMACEUTICALS INC
125,000$7.4B0.65%
43
SMMTSUMMIT THERAPEUTICS INC
350,000$7.2B0.63%Put
44
AKBAAKEBIA THERAPEUTICS INC
2,450,000$6.7B0.58%
45
MNPRMONOPAR THERAPEUTICS INC
79,483$6.5B0.57%
46
ZURAZURA BIO LTD
1,274,351$5.5B0.48%
47
VRDNVIRIDIAN THERAPEUTICS INC
250,000$5.4B0.47%
48
YB4PSAVARA INC
1,500,000$5.4B0.47%
49
NTLAINTELLIA THERAPEUTICS INC
300,000$5.2B0.45%Call
50
OLMAOLEMA PHARMACEUTICALS INC
500,000$4.9B0.43%Call
51
IMVTIMMUNOVANT INC
300,000$4.8B0.42%
525,525,000$4.7B0.41%
53
RVMDREVOLUTION MEDICINES INC
100,000$4.7B0.41%
54
OMEROMEROS CORP
1,133,900$4.6B0.40%Put
55
PCVXVAXCYTE INC
125,000$4.5B0.39%
56
NAMSNEWAMSTERDAM PHARMA COMPANY
245,000$4.2B0.37%
57
CELC 2.75 08/01/31CELCUITY INC
3,000,000$4.0B0.35%
58
PERCEPTIVE CAP SOLUTIONS COR
350,000$3.8B0.33%
59
INSPINSPIRE MED SYS INC
50,000$3.7B0.32%
60
OVIDOVID THERAPEUTICS INC
2,650,000$3.4B0.30%
61
BBIOBRIDGEBIO PHARMA INC
65,000$3.4B0.29%
62
JAZZJAZZ PHARMACEUTICALS PLC
25,000$3.3B0.29%
63
CRNXCRINETICS PHARMACEUTICALS IN
75,000$3.1B0.27%
64
MBXMBX BIOSCIENCES INC
165,000$2.9B0.25%
65
AUTLAUTOLUS THERAPEUTICS PLC
1,750,000$2.9B0.25%
66
OCULOCULAR THERAPEUTIX INC
239,000$2.8B0.24%
67
OACCOAKTREE ACQUISITION CORP III
250,000$2.7B0.23%
68
CLYMCLIMB BIO INC
1,300,000$2.6B0.23%
69
SGMTSAGIMET BIOSCIENCES INC
350,000$2.4B0.21%
70
CATBUSDASTRIA THERAPEUTICS INC
300,000$2.2B0.19%
71
UTHUNITED THERAPEUTICS CORP DEL
5,000$2.1B0.18%
72
GONGERON CORP
1,500,000$2.1B0.18%
73
AVRANTERIS TECHNOLOGIES GLOBAL
450,000$2.0B0.18%
74
OBIOORCHESTRA BIOMED HLDGS INC
727,272$1.8B0.16%
75
EPRXEUPRAXIA PHARMACEUTICALS INC
300,000$1.8B0.15%
76
CGEMCULLINAN THERAPEUTICS INC
263,817$1.6B0.14%
77
ATYRATYR PHARMA INC
2,100,000$1.5B0.13%Put
78
MISTMILESTONE PHARMACEUTICALS IN
666,666$1.3B0.12%
79
CMPSCOMPASS PATHWAYS PLC
200,000$1.1B0.10%
80
NXTCNEXTCURE INC
191,882$1.1B0.10%
81
KPTIKARYOPHARM THERAPEUTICS INC
157,600$1.0B0.09%Call
82
CATXPERSPECTIVE THERAPEUTICS INC
300,000$1.0B0.09%
83
I9DNARBUTUS BIOPHARMA CORP
211,500$960.2M0.08%Call
84
STROSUTRO BIOPHARMA INC
752,722$653.7M0.06%
85
JBIOJADE BIOSCIENCES INC
65,317$563.7M0.05%
86
ENGNENGENE HOLDINGS INC
77,000$525.9M0.05%
87
CNTXCONTEXT THERAPEUTICS INC
402,653$390.1M0.03%
88
RPTXREPARE THERAPEUTICS INC
200,000$352.0M0.03%
89
CBIOCRESCENT BIOPHARMA INC.
17,998$214.0M0.02%
90
ADGMADAGIO MED HLDGS INC
80,000$155.2M0.01%
91
QTTBQ32 BIO INC
27,777$55.0M0.00%
92
SPRYARS PHARMACEUTICALS INC
2,500$25.1M0.00%
93
RCKTWROCKET PHARMACEUTICALS INC
75,000$3.0M0.00%