RTW INVESTMENTS, LP Q4 2022 Filing
Filed February 14, 2023
Portfolio Value
$4.9T
Holdings
77
Report Date
Q4 2022
Filing Type
13F-HR
All Holdings (77 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | ALNYALNYLAM PHARMACEUTICALS INC | 1,683,362 | $400.1B | 8.17% | |
| 2 | —PROMETHEUS BIOSCIENCES INC | 3,354,303 | $369.0B | 7.53% | |
| 3 | RCKTROCKET PHARMACEUTICALS INC | 17,687,772 | $346.1B | 7.07% | |
| 4 | IMCRIMMUNOCORE HLDGS PLC | 5,559,322 | $317.3B | 6.48% | |
| 5 | TMOTHERMO FISHER SCIENTIFIC INC | 435,500 | $239.8B | 4.90% | |
| 6 | AXSMAXSOME THERAPEUTICS INC | 2,980,482 | $229.9B | 4.69% | |
| 7 | 3M4MASIMO CORP | 1,501,493 | $222.1B | 4.53% | |
| 8 | PTCTPTC THERAPEUTICS INC | 5,615,387 | $214.3B | 4.38% | |
| 9 | RAREULTRAGENYX PHARMACEUTICAL IN | 3,966,915 | $183.8B | 3.75% | |
| 10 | ARGXARGENX SE | 482,195 | $182.7B | 3.73% | |
| 11 | MRTXEURMIRATI THERAPEUTICS INC | 3,643,114 | $165.1B | 3.37% | |
| 12 | ESTAESTABLISHMENT LABS HLDGS INC | 2,374,138 | $155.9B | 3.18% | |
| 13 | PENPENUMBRA INC | 698,371 | $155.4B | 3.17% | |
| 14 | TCE2CELLDEX THERAPEUTICS INC NEW | 3,084,215 | $137.5B | 2.81% | |
| 15 | RNAAVIDITY BIOSCIENCES INC | 5,605,566 | $124.4B | 2.54% | |
| 16 | CYTKCYTOKINETICS INC | 2,574,198 | $117.9B | 2.41% | |
| 17 | ILMNILLUMINA INC | 564,375 | $114.1B | 2.33% | |
| 18 | NTRANATERA INC | 2,609,283 | $104.8B | 2.14% | |
| 19 | VCELVERICEL CORP | 3,099,904 | $81.7B | 1.67% | |
| 20 | CUTREURCUTERA INC | 1,798,675 | $79.5B | 1.62% | |
| 21 | ACADACADIA PHARMACEUTICALS INC | 3,670,938 | $58.4B | 1.19% | |
| 22 | GMEDGLOBUS MED INC | 747,685 | $55.5B | 1.13% | |
| 23 | AXNX*AXONICS INC | 884,974 | $55.3B | 1.13% | |
| 24 | VTYXVENTYX BIOSCIENCES INC | 1,551,778 | $50.9B | 1.04% | |
| 25 | RGNXREGENXBIO INC | 1,845,366 | $41.9B | 0.85% | |
| 26 | AVDLAVADEL PHARMACEUTICALS PLC | 5,741,939 | $41.1B | 0.84% | |
| 27 | PTGXPROTAGONIST THERAPEUTICS INC | 3,591,986 | $39.2B | 0.80% | |
| 28 | TORCEURADICET BIO INC | 4,241,472 | $37.9B | 0.77% | |
| 29 | PMVPPMV PHARMACEUTICALS INC | 4,356,920 | $37.9B | 0.77% | |
| 30 | TARSTARSUS PHARMACEUTICALS INC | 2,548,125 | $37.4B | 0.76% | |
| 31 | BCYCBICYCLE THERAPEUTICS PLC | 1,258,587 | $37.3B | 0.76% | |
| 32 | FULCFULCRUM THERAPEUTICS INC | 4,993,279 | $36.4B | 0.74% | |
| 33 | STOKSTOKE THERAPEUTICS INC | 3,870,981 | $35.7B | 0.73% | |
| 34 | TXG10X GENOMICS INC | 872,592 | $31.8B | 0.65% | |
| 35 | OYSTOYSTER PT PHARMA INC | 2,304,977 | $25.7B | 0.53% | |
| 36 | —OLINK HLDG AB | 981,918 | $24.9B | 0.51% | |
| 37 | OMGBPOUTSET MED INC | 909,652 | $23.5B | 0.48% | |
| 38 | GHRSGH RESEARCH PLC | 2,168,957 | $21.1B | 0.43% | |
| 39 | OPHTEURIVERIC BIO INC | 821,288 | $17.6B | 0.36% | |
| 40 | MISTMILESTONE PHARMACEUTICALS IN | 4,315,102 | $17.1B | 0.35% | |
| 41 | —CINCOR PHARMA INC | 1,389,705 | $17.1B | 0.35% | |
| 42 | CCCCC4 THERAPEUTICS INC | 2,819,472 | $16.6B | 0.34% | |
| 43 | ALLKGUSDALLAKOS INC | 1,643,500 | $13.8B | 0.28% | |
| 44 | CSTLCASTLE BIOSCIENCES INC | 516,995 | $12.2B | 0.25% | |
| 45 | GHGUARDANT HEALTH INC | 430,887 | $11.7B | 0.24% | |
| 46 | TERNTERNS PHARMACEUTICALS INC | 1,000,000 | $10.2B | 0.21% | |
| 47 | —HEALTH SCIENCES ACQ CORP 2 | 1,000,000 | $10.0B | 0.20% | |
| 48 | WHWKAADI BIOSCIENCE INC | 764,701 | $9.8B | 0.20% | |
| 49 | GLUEMONTE ROSA THERAPEUTICS INC | 1,214,572 | $9.2B | 0.19% | |
| 50 | SGHTSIGHT SCIENCES INC | 665,323 | $8.1B | 0.17% | |
| 51 | APYXAPYX MEDICAL CORPORATION | 3,398,279 | $8.0B | 0.16% | |
| 52 | URGNUROGEN PHARMA LTD | 857,464 | $7.6B | 0.16% | |
| 53 | IMTXIMMATICS N.V | 845,000 | $7.4B | 0.15% | |
| 54 | RLMDRELMADA THERAPEUTICS INC | 2,067,824 | $7.2B | 0.15% | |
| 55 | ROIVROIVANT SCIENCES LTD | 802,717 | $6.4B | 0.13% | |
| 56 | JNCEEURJOUNCE THERAPEUTICS INC | 5,106,341 | $5.7B | 0.12% | |
| 57 | IMUXIMMUNIC INC | 3,861,290 | $5.4B | 0.11% | |
| 58 | MLTXMOONLAKE IMMUNOTHERAPEUTICS | 500,000 | $5.3B | 0.11% | |
| 59 | —SUMMIT HEALTHCRE ACQUISTN CO | 500,000 | $5.1B | 0.10% | |
| 60 | —ARYA SCIENCES ACQU CORP IV | 500,000 | $5.0B | 0.10% | |
| 61 | —ARYA SCIENCES ACQUISITN CORP | 500,000 | $5.0B | 0.10% | |
| 62 | TNYATENAYA THERAPEUTICS INC | 2,458,750 | $4.9B | 0.10% | |
| 63 | DMTKQDERMTECH INC | 2,718,356 | $4.8B | 0.10% | |
| 64 | —AKOYA BIOSCIENCES INC | 483,815 | $4.6B | 0.09% | |
| 65 | TELATELA BIO INC | 390,364 | $4.5B | 0.09% | |
| 66 | BWAYBRAINSWAY LTD | 1,602,381 | $4.0B | 0.08% | |
| 67 | XGNEXAGEN INC | 1,364,336 | $3.3B | 0.07% | |
| 68 | JNJJOHNSON & JOHNSON | 18,127 | $3.2B | 0.07% | |
| 69 | —MEDICUS SCIENCES ACQUISITION | 300,000 | $3.0B | 0.06% | |
| 70 | THRDTHIRD HARMONIC BIO INC | 609,687 | $2.6B | 0.05% | |
| 71 | MASS908 DEVICES INC | 312,000 | $2.4B | 0.05% | |
| 72 | LUNGPULMONX CORP | 275,000 | $2.3B | 0.05% | |
| 73 | NYXHNYXOAH S A | 269,993 | $1.3B | 0.03% | |
| 74 | NAUTNAUTILUS BIOTECHNOLOGY INC | 600,000 | $1.1B | 0.02% | |
| 75 | —SCIENCE 37 HOLDINGS INC | 2,586,108 | $1.1B | 0.02% | |
| 76 | —MIROMATRIX MED INC | 280,000 | $837.2M | 0.02% | |
| 77 | —MEDICUS SCIENCES ACQUISITION | 33,331 | $3.0M | 0.00% |