HighVista Strategies LLC Q4 2025 Filing

Filed February 17, 2026

Portfolio Value

$388.0B

Holdings

145

Report Date

Q4 2025

Filing Type

13F-HR

All Holdings (145 positions)

#StockSharesValue% PortfolioType
1
DBCINVESCO DB COMMDY INDX TRCK
1,057,238$23.0B5.93%
2
GPCRSTRUCTURE THERAPEUTICS INC
193,001$13.0B3.35%
3
COGTCOGENT BIOSCIENCES INC
336,667$11.0B2.84%
4
VRDNVIRIDIAN THERAPEUTICS INC
372,472$11.0B2.84%
5
ABVXABIVAX SA
72,185$9.0B2.32%
6
RVMDREVOLUTION MEDICINES INC
120,240$9.0B2.32%
7
MAZEMAZE THERAPEUTICS INC
170,353$7.0B1.80%
8
NUVLNUVALENT INC
73,287$7.0B1.80%
9
CYTKCYTOKINETICS INC
114,564$7.0B1.80%
10
TERNTERNS PHARMACEUTICALS INC
175,462$7.0B1.80%
11
PRAXPRAXIS PRECISION MEDICINES I
25,841$7.0B1.80%
12
SLNOSOLENO THERAPEUTICS INC
135,069$6.0B1.55%
13
BBIOBRIDGEBIO PHARMA INC
80,205$6.0B1.55%
14
SYRESPYRE THERAPEUTICS INC
188,206$6.0B1.55%
15
APGEAPOGEE THERAPEUTICS INC
89,229$6.0B1.55%
16
PTGXPROTAGONIST THERAPEUTICS INC
73,545$6.0B1.55%
17
IM8NINSMED INC
39,400$6.0B1.55%
18
OLMAOLEMA PHARMACEUTICALS INC
241,489$6.0B1.55%
19
LQDALIQUIDIA CORPORATION
156,003$5.0B1.29%
20
CDTXCIDARA THERAPEUTICS INC
22,928$5.0B1.29%
21
IMVTIMMUNOVANT INC
221,883$5.0B1.29%
22
PCVXVAXCYTE INC
114,049$5.0B1.29%
23
EWTXEDGEWISE THERAPEUTICS INC
171,137$4.0B1.03%
24
RLAYRELAY THERAPEUTICS INC
545,079$4.0B1.03%
25
ACLXARCELLX INC
75,002$4.0B1.03%
26
TARSTARSUS PHARMACEUTICALS INC
53,564$4.0B1.03%
27
PHVSPHARVARIS N V
162,370$4.0B1.03%
28
AGIOAGIOS PHARMACEUTICALS INC
147,662$4.0B1.03%
29
RYTMRHYTHM PHARMACEUTICALS INC
42,867$4.0B1.03%
30
AMZNAMAZON COM INC
17,397$4.0B1.03%
31
MLYSMINERALYS THERAPEUTICS INC
124,544$4.0B1.03%
32
OCULOCULAR THERAPEUTIX INC
344,067$4.0B1.03%
33
STOKSTOKE THERAPEUTICS INC
115,539$3.0B0.77%
34
GHRSGH RESEARCH PLC
240,524$3.0B0.77%
35
PALIPALISADE BIO INC
1,300,031$3.0B0.77%
36
APLSAPELLIS PHARMACEUTICALS INC
150,776$3.0B0.77%
37
GHGUARDANT HEALTH INC
36,758$3.0B0.77%
38
LBRXLB PHARMACEUTICALS INC
140,107$3.0B0.77%
39
ARGXARGENX SE
3,588$3.0B0.77%
40
XOMAXOMA ROYALTY CORPORATION
112,917$3.0B0.77%
41
MSFTMICROSOFT CORP
6,537$3.0B0.77%
42
CMPSCOMPASS PATHWAYS PLC
498,933$3.0B0.77%
43
T7DTRANSDIGM GROUP INC
2,175$2.0B0.52%
44
RNAAVIDITY BIOSCIENCES INC
40,020$2.0B0.52%
45
VVISA INC
6,291$2.0B0.52%
46
NVDANVIDIA CORPORATION
14,220$2.0B0.52%
47
SEPNSEPTERNA INC
78,682$2.0B0.52%
48
CRMSALESFORCE INC
8,613$2.0B0.52%
49
AXSMAXSOME THERAPEUTICS INC
11,131$2.0B0.52%
50
BBOTBRIDGEBIO ONCOLOGY THERAPEUT
229,263$2.0B0.52%
51
AMLXAMYLYX PHARMACEUTICALS INC
238,812$2.0B0.52%
52
APPAPPLOVIN CORP
2,482$1.0B0.26%
53
NUNU HLDGS LTD
62,570$1.0B0.26%
54
RKTROCKET COS INC
97,430$1.0B0.26%
55
CELCCELCUITY INC
16,543$1.0B0.26%
56
AVGOBROADCOM INC
5,639$1.0B0.26%
57
XPOXPO INC
12,723$1.0B0.26%
58
PTCPTC INC
6,374$1.0B0.26%
59
METAMETA PLATFORMS INC
2,562$1.0B0.26%
60
HPEHEWLETT PACKARD ENTERPRISE C
76,181$1.0B0.26%
61
CIENCIENA CORP
5,185$1.0B0.26%
62
CNTACENTESSA PHARMACEUTICALS PLC
44,490$1.0B0.26%
63
APGAPI GROUP CORP
30,958$1.0B0.26%
64
TMOTHERMO FISHER SCIENTIFIC INC
2,269$1.0B0.26%
65
TLNTALEN ENERGY CORP
3,488$1.0B0.26%
66
ACHCACADIA HEALTHCARE COMPANY IN
81,630$1.0B0.26%
67
AMRZAMRIZE LTD
33,468$1.0B0.26%
68
MAMASTERCARD INCORPORATED
2,784$1.0B0.26%
69
DNTHDIANTHUS THERAPEUTICS INC
48,484$1.0B0.26%
70
AVTXAVALO THERAPEUTICS INC
95,631$1.0B0.26%
71
LITELUMENTUM HLDGS INC
4,317$1.0B0.26%
72
SNDKSANDISK CORP
4,378$1.0B0.26%
73
MDGLMADRIGAL PHARMACEUTICALS INC
2,839$1.0B0.26%
74
NAMSNEWAMSTERDAM PHARMA COMPANY
35,586$1.0B0.26%
75
GEVGE VERNOVA INC
1,768$1.0B0.26%
76
RXORXO INC
90,938$1.0B0.26%
77
SCHWSCHWAB CHARLES CORP
10,601$1.0B0.26%
78
MTZMASTEC INC
5,027$1.0B0.26%
79
GOOGALPHABET INC
6,277$1.0B0.26%
80
K6BKBR INC
30,006$1.0B0.26%
81
UTHUNITED THERAPEUTICS CORP DEL
2,330$1.0B0.26%
82
FLSFLOWSERVE CORP
24,958$1.0B0.26%
83
WDAYWORKDAY INC
6,486$1.0B0.26%
84
TCE2CELLDEX THERAPEUTICS INC NEW
51,805$1.0B0.26%
85
DYNDYNE THERAPEUTICS INC
59,643$1.0B0.26%
86
BKNGBOOKING HOLDINGS INC
243$1.0B0.26%
87
UNFUNIFIRST CORP MASS
7,727$1.0B0.26%
88
RBCRBC BEARINGS INC
2,703$1.0B0.26%
89
NEENEXTERA ENERGY INC
19,285$1.0B0.26%
90
ELVNENLIVEN THERAPEUTICS INC
82,536$1.0B0.26%
91
RDDTREDDIT INC
5,300$1.0B0.26%
92
FERGFERGUSON ENTERPRISES INC
6,973$1.0B0.26%
93
UUNITY SOFTWARE INC
28,663$1.0B0.26%
94
TRVITREVI THERAPEUTICS INC
106,159$1.0B0.26%
95
EQTEQT CORP
27,090$1.0B0.26%
96
CGONCG ONCOLOGY INC
29,325$1.0B0.26%
97
IMCRIMMUNOCORE HLDGS PLC
32,998$1.0B0.26%
98
OFIXORTHOFIX MED INC
85,049$1.0B0.26%
99
QXOQXO INC
58,720$1.0B0.26%
100
CLHCLEAN HARBORS INC
6,243$1.0B0.26%
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