Rock Springs Capital Management LP Q4 2025 Filing
Filed February 17, 2026
Portfolio Value
$2.0T
Holdings
98
Report Date
Q4 2025
Filing Type
13F-HR
All Holdings (98 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | LLYELI LILLY & CO | 105,400 | $113.3B | 5.81% | |
| 2 | RVMDREVOLUTION MEDICINES INC | 1,335,270 | $106.4B | 5.45% | |
| 3 | ARGXARGENX SE | 103,250 | $86.8B | 4.45% | |
| 4 | TVTXTRAVERE THERAPEUTICS INC | 2,210,322 | $84.5B | 4.33% | |
| 5 | MDGLMADRIGAL PHARMACEUTICALS INC | 139,618 | $81.3B | 4.17% | |
| 6 | RYTMRHYTHM PHARMACEUTICALS INC | 695,010 | $74.4B | 3.81% | |
| 7 | EXASEXACT SCIENCES CORP | 601,800 | $61.1B | 3.13% | |
| 8 | MIRMMIRUM PHARMACEUTICALS INC | 762,294 | $60.2B | 3.09% | |
| 9 | IM8NINSMED INC | 319,250 | $55.6B | 2.85% | |
| 10 | GPCRSTRUCTURE THERAPEUTICS INC | 748,236 | $52.0B | 2.67% | |
| 11 | ISRGINTUITIVE SURGICAL INC | 82,000 | $46.4B | 2.38% | |
| 12 | CDTXCIDARA THERAPEUTICS INC | 204,878 | $45.3B | 2.32% | |
| 13 | ASNDASCENDIS PHARMA A/S | 203,500 | $43.4B | 2.23% | |
| 14 | IRTCIRHYTHM TECHNOLOGIES INC | 235,000 | $41.7B | 2.14% | |
| 15 | KYMRKYMERA THERAPEUTICS INC | 496,871 | $38.7B | 1.98% | |
| 16 | BSXBOSTON SCIENTIFIC CORP | 399,050 | $38.0B | 1.95% | |
| 17 | PENPENUMBRA INC | 120,500 | $37.5B | 1.92% | |
| 18 | XENEXENON PHARMACEUTICALS INC | 787,788 | $35.3B | 1.81% | |
| 19 | SRRKSCHOLAR ROCK HLDG CORP | 733,477 | $32.3B | 1.66% | |
| 20 | COGTCOGENT BIOSCIENCES INC | 849,030 | $30.2B | 1.55% | |
| 21 | RAREULTRAGENYX PHARMACEUTICAL IN | 1,267,241 | $29.1B | 1.49% | |
| 22 | VERAVERA THERAPEUTICS INC | 568,579 | $28.8B | 1.48% | |
| 23 | ALNYALNYLAM PHARMACEUTICALS INC | 71,250 | $28.3B | 1.45% | |
| 24 | AM6AMICUS THERAPEUTICS INC | 1,929,931 | $27.5B | 1.41% | |
| 25 | XBISPDR SERIES TRUST | 222,000 | $27.1B | 1.39% | |
| 26 | THCTENET HEALTHCARE CORP | 125,000 | $24.8B | 1.27% | |
| 27 | DC4DEXCOM INC | 347,300 | $23.1B | 1.18% | |
| 28 | AGIOAGIOS PHARMACEUTICALS INC | 799,163 | $21.8B | 1.12% | |
| 29 | TARSTARSUS PHARMACEUTICALS INC | 260,344 | $21.3B | 1.09% | |
| 30 | CMPXCOMPASS THERAPEUTICS INC | 3,927,202 | $21.1B | 1.08% | |
| 31 | NAMSNEWAMSTERDAM PHARMA COMPANY | 588,794 | $20.7B | 1.06% | Call |
| 32 | AZTAAZENTA INC | 569,100 | $18.9B | 0.97% | |
| 33 | TCE2CELLDEX THERAPEUTICS INC NEW | 692,538 | $18.8B | 0.96% | |
| 34 | CAICARIS LIFE SCIENCES INC | 687,500 | $18.5B | 0.95% | |
| 35 | ZBIOZENAS BIOPHARMA INC | 502,077 | $18.2B | 0.93% | |
| 36 | DYNDYNE THERAPEUTICS INC | 912,955 | $17.9B | 0.92% | |
| 37 | NBIXNEUROCRINE BIOSCIENCES INC | 125,500 | $17.8B | 0.91% | |
| 38 | PHVSPHARVARIS N V | 623,402 | $17.3B | 0.89% | |
| 39 | MLYSMINERALYS THERAPEUTICS INC | 427,596 | $15.5B | 0.80% | |
| 40 | PHRPHREESIA INC | 876,600 | $14.8B | 0.76% | |
| 41 | ZLABZAI LAB LTD | 811,546 | $14.3B | 0.73% | |
| 42 | DHRDANAHER CORPORATION | 61,500 | $14.1B | 0.72% | |
| 43 | UNHUNITEDHEALTH GROUP INC | 40,800 | $13.5B | 0.69% | |
| 44 | ARDXARDELYX INC | 2,299,473 | $13.4B | 0.69% | |
| 45 | ACRSACLARIS THERAPEUTICS INC | 4,453,741 | $13.4B | 0.69% | |
| 46 | SMMTSUMMIT THERAPEUTICS INC | 710,000 | $12.4B | 0.64% | |
| 47 | ELVNENLIVEN THERAPEUTICS INC | 798,405 | $12.3B | 0.63% | |
| 48 | INSPINSPIRE MED SYS INC | 131,000 | $12.1B | 0.62% | |
| 49 | OMDAOMADA HEALTH INC | 740,000 | $11.7B | 0.60% | |
| 50 | SLNOSOLENO THERAPEUTICS INC | 247,053 | $11.4B | 0.59% | |
| 51 | ACLXARCELLX INC | 169,859 | $11.1B | 0.57% | |
| 52 | EVHEVOLENT HEALTH INC | 2,675,000 | $10.7B | 0.55% | |
| 53 | GOSSGOSSAMER BIO INC | 3,266,960 | $10.1B | 0.52% | |
| 54 | MBXMBX BIOSCIENCES INC | 282,624 | $8.9B | 0.46% | |
| 55 | CNTACENTESSA PHARMACEUTICALS PLC | 324,015 | $8.1B | 0.42% | |
| 56 | HTFLHEARTFLOW INC | 277,700 | $8.1B | 0.42% | |
| 57 | BBIOBRIDGEBIO PHARMA INC | 103,500 | $7.9B | 0.41% | |
| 58 | REGNREGENERON PHARMACEUTICALS | 10,100 | $7.8B | 0.40% | |
| 59 | IMNMIMMUNOME INC | 347,666 | $7.5B | 0.38% | |
| 60 | RAPTRAPT THERAPEUTICS INC | 213,731 | $7.2B | 0.37% | |
| 61 | BCAXBICARA THERAPEUTICS INC | 429,095 | $7.2B | 0.37% | |
| 62 | EWEDWARDS LIFESCIENCES CORP | 82,500 | $7.0B | 0.36% | |
| 63 | GOSS 5 06/01/27GOSSAMER BIO INC | 9,573,000 | $6.6B | 0.34% | |
| 64 | ATECALPHATEC HLDGS INC | 302,500 | $6.4B | 0.33% | |
| 65 | AMLXAMYLYX PHARMACEUTICALS INC | 499,764 | $6.0B | 0.31% | |
| 66 | TMOTHERMO FISHER SCIENTIFIC INC | 10,000 | $5.8B | 0.30% | |
| 67 | JANXJANUX THERAPEUTICS INC | 358,798 | $5.0B | 0.25% | |
| 68 | SGRYSURGERY PARTNERS INC | 310,000 | $4.8B | 0.25% | |
| 69 | EYPTEYEPOINT INC | 258,739 | $4.7B | 0.24% | |
| 70 | PTCTPTC THERAPEUTICS INC | 61,879 | $4.7B | 0.24% | |
| 71 | AGLAGILON HEALTH INC | 6,500,000 | $4.5B | 0.23% | |
| 72 | MRSNMERSANA THERAPEUTICS INC | 152,586 | $4.4B | 0.23% | |
| 73 | TERNTERNS PHARMACEUTICALS INC | 108,481 | $4.4B | 0.22% | |
| 74 | RCUSARCUS BIOSCIENCES INC | 180,000 | $4.3B | 0.22% | |
| 75 | EDAEDAP TMS S A | 1,286,500 | $4.2B | 0.22% | |
| 76 | OCULOCULAR THERAPEUTIX INC | 345,820 | $4.2B | 0.22% | |
| 77 | LENZLENZ THERAPEUTICS INC | 257,460 | $4.1B | 0.21% | |
| 78 | TLPHTALPHERA INC | 3,589,186 | $4.1B | 0.21% | |
| 79 | SIONSIONNA THERAPEUTICS INC | 99,429 | $4.1B | 0.21% | |
| 80 | TBPHTHERAVANCE BIOPHARMA INC | 208,771 | $3.9B | 0.20% | |
| 81 | ALKSALKERMES PLC | 139,228 | $3.9B | 0.20% | |
| 82 | APLSAPELLIS PHARMACEUTICALS INC | 150,500 | $3.8B | 0.19% | |
| 83 | —INDIVIOR PLC | 105,100 | $3.8B | 0.19% | |
| 84 | ERASERASCA INC | 951,710 | $3.5B | 0.18% | |
| 85 | TNGXTANGO THERAPEUTICS INC | 386,915 | $3.4B | 0.18% | |
| 86 | OLMAOLEMA PHARMACEUTICALS INC | 98,240 | $2.5B | 0.13% | |
| 87 | CYTKCYTOKINETICS INC | 35,853 | $2.3B | 0.12% | |
| 88 | PCVXVAXCYTE INC | 47,000 | $2.2B | 0.11% | |
| 89 | NGNENEUROGENE INC | 104,339 | $2.1B | 0.11% | |
| 90 | JSPRJASPER THERAPEUTICS INC | 1,100,726 | $2.0B | 0.10% | |
| 91 | ROIVROIVANT SCIENCES LTD | 88,750 | $1.9B | 0.10% | |
| 92 | HTDCORCEPT THERAPEUTICS INC | 50,250 | $1.7B | 0.09% | |
| 93 | ACHCACADIA HEALTHCARE COMPANY IN | 120,000 | $1.7B | 0.09% | |
| 94 | TEVATEVA PHARMACEUTICAL INDS LTD | 45,500 | $1.4B | 0.07% | |
| 95 | MLTXMOONLAKE IMMUNOTHERAPEUTICS | 61,700 | $813.0M | 0.04% | |
| 96 | LEGNLEGEND BIOTECH CORP | 33,800 | $734.0M | 0.04% | |
| 97 | JAZZJAZZ PHARMACEUTICALS PLC | 1,750 | $297.0M | 0.02% | |
| 98 | NUVB/WSNUVATION BIO INC | 134,028 | $44.0M | 0.00% |