SPHERA FUNDS MANAGEMENT LTD. Q4 2024 Filing

Filed February 14, 2025

Portfolio Value

$553.1M

Holdings

103

Report Date

Q4 2024

Filing Type

13F-HR

All Holdings (103 positions)

#StockSharesValue% PortfolioType
1
TEVATEVA PHARMACEUTICAL INDS LTD
1,569,181$34.6M6.25%
2
BBIOBRIDGEBIO PHARMA INC
905,279$24.8M4.49%
3
SNYSANOFI
384,515$18.5M3.35%
4
SNDXSYNDAX PHARMACEUTICALS INC
1,381,241$18.3M3.30%
5
AZNASTRAZENECA PLC
225,060$14.7M2.67%
6
AMZNAMAZON COM INC
62,607$13.7M2.48%
7
PRAXPRAXIS PRECISION MEDICINES I
174,583$13.4M2.43%Call
8
NVMINOVA LTD
68,146$13.4M2.43%
9
METAMETA PLATFORMS INC
21,001$12.3M2.22%
10
SRPTSAREPTA THERAPEUTICS INC
98,921$12.0M2.17%
11
TCE2CELLDEX THERAPEUTICS INC NEW
474,103$12.0M2.17%
12
ELDNELEDON PHARMACEUTICALS INC
2,551,619$10.5M1.90%
13
LLYELI LILLY & CO
13,190$10.2M1.84%
14
JNJJOHNSON & JOHNSON
69,831$10.1M1.83%
15
RAREULTRAGENYX PHARMACEUTICAL IN
228,776$9.6M1.74%
16
CYTKCYTOKINETICS INC
203,021$9.6M1.73%Call
17
MSFTMICROSOFT CORP
22,327$9.4M1.70%
18
MRVLMARVELL TECHNOLOGY INC
78,611$8.7M1.57%
19
TSEMTOWER SEMICONDUCTOR LTD
166,149$8.6M1.55%
20
NVONOVO-NORDISK A S
98,080$8.4M1.53%
21
WIXWIX COM LTD
39,253$8.4M1.52%
22
GOOGALPHABET INC
43,500$8.3M1.50%
23
PHVSPHARVARIS N V
388,183$7.4M1.35%
24
NSYNICE LTD
42,500$7.2M1.30%
25
CHKPCHECK POINT SOFTWARE TECH LT
35,635$6.7M1.20%
26
APLSAPELLIS PHARMACEUTICALS INC
206,251$6.6M1.19%
27
IMTXIMMATICS N.V
921,111$6.5M1.18%
28
ANNXANNEXON INC
1,243,039$6.4M1.15%
29
ABBVABBVIE INC
34,256$6.1M1.10%
30
MRKMERCK & CO INC
59,600$5.9M1.07%
31
JSPRJASPER THERAPEUTICS INC
274,320$5.9M1.06%Put
32
BHVNBIOHAVEN LTD
156,494$5.8M1.06%
33
RZLTREZOLUTE INC
1,165,895$5.7M1.03%
34
FROGJFROG LTD
190,381$5.6M1.01%
35
DYNDYNE THERAPEUTICS INC
236,262$5.6M1.01%
36
MRUSMERUS N V
130,532$5.5M0.99%
37
NTLAINTELLIA THERAPEUTICS INC
466,080$5.4M0.98%
38
HNMORMAT TECHNOLOGIES INC
79,000$5.3M0.97%
39
KURAKURA ONCOLOGY INC
610,087$5.3M0.96%
40
ACADACADIA PHARMACEUTICALS INC
288,539$5.3M0.96%
41
SEDGSOLAREDGE TECHNOLOGIES INC
375,000$5.1M0.92%
42
ORA 2.5 07/15/27 SEPTORMAT TECHNOLOGIES INC
5,037,000$5.0M0.91%
43
NVSNNOVARTIS AG
50,000$4.9M0.88%
44
HELPCYBIN INC
538,111$4.7M0.86%
45
SKYESKYE BIOSCIENCE INC
1,564,628$4.4M0.80%
46
GSKGSK PLC
130,000$4.4M0.79%
47
ETNBGBP89BIO INC
556,532$4.4M0.79%
48
VIRVIR BIOTECHNOLOGY INC
581,829$4.3M0.77%
49
DAWNDAY ONE BIOPHARMACEUTICALS I
334,987$4.2M0.77%
50
VKTXVIKING THERAPEUTICS INC
103,270$4.2M0.75%
51
PLRXPLIANT THERAPEUTICS INC
297,362$3.9M0.71%
52
AVGOBROADCOM INC
16,880$3.9M0.71%
53
SRRKSCHOLAR ROCK HLDG CORP
90,193$3.9M0.70%
54
TVTXTRAVERE THERAPEUTICS INC
220,700$3.8M0.69%
55
ENGNENGENE HOLDINGS INC
560,000$3.7M0.67%
56
YB4PSAVARA INC
1,211,533$3.7M0.67%
57
ARWRARROWHEAD PHARMACEUTICALS IN
197,550$3.7M0.67%
58
JANXJANUX THERAPEUTICS INC
68,333$3.7M0.66%
59
ACOGALPHA COGNITION INC
620,000$3.7M0.66%
60
SWTXSPRINGWORKS THERAPEUTICS INC
100,000$3.6M0.65%
61
BIIBBIOGEN INC
22,738$3.5M0.63%
62
ENPHENPHASE ENERGY INC
50,198$3.4M0.62%
63
RCKTROCKET PHARMACEUTICALS INC
271,792$3.4M0.62%
64
INZYINOZYME PHARMA INC
1,191,140$3.3M0.60%
65
CAMTCAMTEK LTD
36,287$2.9M0.53%
66
CRVSCORVUS PHARMACEUTICALS INC
500,491$2.7M0.48%
67
CRGXCARGO THERAPEUTICS INC
179,674$2.6M0.47%
68
WDAYWORKDAY INC
10,000$2.6M0.47%
69
VIGLVIGIL NEUROSCIENCE INC
1,502,429$2.6M0.46%
70
NTRNUTRIEN LTD
55,894$2.5M0.45%
71
CGEMCULLINAN THERAPEUTICS INC
205,000$2.5M0.45%
72
PFEPFIZER INC
90,000$2.4M0.43%
73
VTGNVISTAGEN THERAPEUTICS INC
808,550$2.4M0.43%
74
MLYSMINERALYS THERAPEUTICS INC
190,672$2.3M0.42%
75
ISIIONIS PHARMACEUTICALS INC
63,821$2.2M0.40%
76
VTYXVENTYX BIOSCIENCES INC
1,012,749$2.2M0.40%
77
ORICORIC PHARMACEUTICALS INC
273,213$2.2M0.40%
78
CMMBCHEMOMAB THERAPEUTICS LTD
1,214,575$2.2M0.40%
79
XENEXENON PHARMACEUTICALS INC
52,097$2.0M0.37%
80
PMNEURPROMIS NEUROSCIENCES INC
1,929,297$1.8M0.33%
81
UBERUBER TECHNOLOGIES INC
30,000$1.8M0.33%
82
LRMRLARIMAR THERAPEUTICS INC
455,604$1.8M0.32%
83
ZURAZURA BIO LTD
690,718$1.7M0.31%
84
SHLTSHL TELEMEDICINE LTD
632,456$1.7M0.30%
85
CATXPERSPECTIVE THERAPEUTICS INC
460,247$1.5M0.27%
86
CATBUSDASTRIA THERAPEUTICS INC
139,800$1.2M0.23%
87
BMYBRISTOL-MYERS SQUIBB CO
20,000$1.1M0.20%
88
MERSANA THERAPEUTICS INC
690,272$987K0.18%
89
ALMSALUMIS INC
125,000$982K0.18%
90
HOWLWEREWOLF THERAPEUTICS INC
626,810$927K0.17%
91
APREAPREA THERAPEUTICS INC
270,000$888K0.16%
92
PERIPERION NETWORK LTD
102,612$869K0.16%
93
OKURONKURE THERAPEUTICS INC
87,354$751K0.14%
94
KZRKEZAR LIFE SCIENCES INC
108,473$728K0.13%
95
FATEFATE THERAPEUTICS INC
397,177$655K0.12%
96
ALECALECTOR INC
324,639$613K0.11%
97
ELEVATION ONCOLOGY INC
1,018,562$573K0.10%
98
CLYMCLIMB BIO INC
251,935$453K0.08%
99
KYTXKYVERNA THERAPEUTICS INC
118,758$444K0.08%
100
CGENCOMPUGEN LTD
177,094$270K0.05%
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