PERCEPTIVE ADVISORS LLC Q4 2025 Filing
Filed February 17, 2026
Portfolio Value
$5.6B
Holdings
116
Report Date
Q4 2025
Filing Type
13F-HR
All Holdings (116 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | PRAXPRAXIS PRECISION MEDICINES I | 1,995,986 | $588.3B | 10486.03% | |
| 2 | CELCCELCUITY INC | 3,160,200 | $315.2B | 5618.22% | |
| 3 | RYTMRHYTHM PHARMACEUTICALS INC | 2,546,391 | $272.6B | 4858.31% | |
| 4 | ASNDASCENDIS PHARMA A/S | 1,081,421 | $230.6B | 4110.34% | |
| 5 | APGEAPOGEE THERAPEUTICS INC | 2,330,651 | $175.9B | 3135.62% | |
| 6 | ROIVROIVANT SCIENCES LTD | 7,985,461 | $173.3B | 3088.68% | |
| 7 | NUVLNUVALENT INC | 1,665,105 | $167.5B | 2985.45% | |
| 8 | TVTXTRAVERE THERAPEUTICS INC | 4,278,180 | $163.5B | 2913.74% | |
| 9 | XBISPDR SERIES TRUST | 1,100,000 | $134.1B | 2390.66% | Put |
| 10 | EXASEXACT SCIENCES CORP | 1,200,487 | $121.9B | 2173.17% | |
| 11 | PTGXPROTAGONIST THERAPEUTICS INC | 1,350,425 | $117.9B | 2102.32% | |
| 12 | INBXINHIBRX BIOSCIENCES INC | 1,452,707 | $114.8B | 2045.58% | |
| 13 | EWTXEDGEWISE THERAPEUTICS | 4,457,974 | $110.6B | 1971.81% | |
| 14 | IMTXIMMATICS N.V | 10,383,456 | $109.0B | 1943.32% | |
| 15 | SYRESPYRE THERAPEUTICS INC | 3,069,225 | $100.5B | 1792.19% | |
| 16 | AMLXAMYLYX PHARMACEUTICALS INC | 8,284,882 | $100.1B | 1783.88% | |
| 17 | ACLXARCELLX INC | 1,466,071 | $95.6B | 1703.78% | |
| 18 | VRDNVIRIDIAN THERAPEUTICS INC | 3,042,703 | $94.7B | 1687.76% | |
| 19 | BSXBOSTON SCIENTIFIC CORP | 979,000 | $93.3B | 1663.86% | |
| 20 | AM6AMICUS THERAPEUTICS INC | 6,370,851 | $90.7B | 1617.03% | |
| 21 | ZYMEZYMEWORKS INC | 3,261,850 | $85.9B | 1530.83% | |
| 22 | CATBUSDASTRIA THERAPEUTICS INC | 6,485,420 | $84.9B | 1513.19% | |
| 23 | MGTXMEIRAGTX HLDGS PLC | 10,326,103 | $82.1B | 1463.24% | |
| 24 | AORTARTIVION INC | 1,722,290 | $78.6B | 1400.16% | |
| 25 | CNTACENTESSA PHARMACEUTICALS PLC | 2,917,634 | $73.0B | 1300.65% | |
| 26 | DYNDYNE THERAPEUTICS INC | 3,478,944 | $68.0B | 1212.92% | |
| 27 | NRIXNURIX THERAPEUTICS INC | 3,555,877 | $67.5B | 1202.33% | |
| 28 | SLDBSOLID BIOSCIENCES INC | 11,833,539 | $66.7B | 1189.62% | |
| 29 | BLTEBELITE BIO INC | 414,239 | $66.3B | 1181.06% | |
| 30 | ABVXABIVAX SA | 458,343 | $61.8B | 1101.71% | |
| 31 | IVVDINVIVYD INC | 21,785,166 | $53.8B | 959.11% | |
| 32 | ENGNENGENE HOLDINGS INC | 5,869,076 | $53.0B | 944.64% | |
| 33 | RGENREPLIGEN CORP | 315,541 | $51.7B | 921.59% | |
| 34 | IMVTIMMUNOVANT INC | 1,994,890 | $50.7B | 903.88% | |
| 35 | ISRGINTUITIVE SURGICAL INC | 87,919 | $49.8B | 887.53% | |
| 36 | SIONSIONNA THERAPEUTICS INC | 1,179,098 | $48.5B | 864.63% | |
| 37 | NBIXNEUROCRINE BIOSCIENCES INC | 331,050 | $47.0B | 836.89% | |
| 38 | DHRDANAHER CORPORATION | 200,000 | $45.8B | 816.07% | |
| 39 | ORKAORUKA THERAPEUTICS INC | 1,476,501 | $44.8B | 797.68% | |
| 40 | CTMXCYTOMX THERAPEUTICS INC | 9,680,185 | $41.2B | 735.03% | |
| 41 | OMDAOMADA HEALTH INC | 2,396,330 | $37.8B | 674.01% | |
| 42 | CDTXCIDARA THERAPEUTICS INC | 165,131 | $36.5B | 650.15% | |
| 43 | IRONDISC MEDICINE INC | 450,743 | $35.8B | 637.99% | |
| 44 | DRUGBRIGHT MINDS BIOSCIENCES INC | 449,290 | $35.1B | 624.96% | |
| 45 | PENPENUMBRA INC | 110,529 | $34.4B | 612.52% | |
| 46 | ANROALTO NEUROSCIENCE INC | 1,784,393 | $31.8B | 566.14% | |
| 47 | CAICARIS LIFE SCIENCES INC | 1,136,206 | $30.7B | 546.39% | |
| 48 | JAZZJAZZ PHARMACEUTICALS PLC | 170,000 | $28.9B | 515.13% | |
| 49 | PALIPALISADE BIO INC | 12,050,000 | $28.3B | 504.73% | |
| 50 | RAPTRAPT THERAPEUTICS INC | 825,890 | $28.0B | 498.58% | |
| 51 | PVLAPALVELLA THERAPEUTICS INC NE | 266,287 | $27.9B | 496.80% | |
| 52 | AXSMAXSOME THERAPEUTICS INC | 148,900 | $27.2B | 484.73% | |
| 53 | AXGNAXOGEN INC | 784,140 | $25.7B | 457.45% | |
| 54 | XFORX4 PHARMACEUTICALS INC | 6,314,452 | $25.3B | 450.19% | |
| 55 | BCRXBIOCRYST PHARMACEUTICALS INC | 3,162,529 | $24.7B | 439.67% | |
| 56 | NAUTNAUTILUS BIOTECHNOLOGY INC | 12,594,211 | $24.6B | 437.73% | |
| 57 | KODKODIAK SCIENCES INC | 848,900 | $23.7B | 423.06% | |
| 58 | BIIBBIOGEN INC | 124,000 | $21.8B | 388.96% | |
| 59 | ALDXALDEYRA THERAPEUTICS INC | 4,185,632 | $21.7B | 386.45% | |
| 60 | OBIOORCHESTRA BIOMED HLDGS INC | 5,127,256 | $21.3B | 379.27% | |
| 61 | MIRMMIRUM PHARMACEUTICALS INC | 259,545 | $20.5B | 365.42% | |
| 62 | RAPPRAPPORT THERAPEUTICS INC | 673,923 | $20.4B | 364.44% | |
| 63 | GRALGRAIL INC | 237,342 | $20.3B | 362.09% | |
| 64 | IRTCIRHYTHM TECHNOLOGIES INC | 108,000 | $19.2B | 341.57% | |
| 65 | BBNXBETA BIONICS INC | 602,944 | $18.4B | 327.45% | |
| 66 | CVSCVS HEALTH CORP | 220,000 | $17.5B | 311.20% | |
| 67 | CTNMCONTINEUM THERAPEUTICS INC | 1,464,592 | $16.7B | 298.38% | |
| 68 | GHGUARDANT HEALTH INC | 160,000 | $16.3B | 291.29% | |
| 69 | ADMAADMA BIOLOGICS INC | 883,468 | $16.1B | 287.22% | |
| 70 | RLAYRELAY THERAPEUTICS INC | 1,903,245 | $16.1B | 286.99% | |
| 71 | GKOSGLAUKOS CORP | 140,000 | $15.8B | 281.75% | |
| 72 | DC4DEXCOM INC | 225,758 | $15.0B | 267.06% | |
| 73 | YB4PSAVARA INC | 2,400,000 | $14.5B | 257.95% | |
| 74 | CELC 2.75 08/01/31CELCUITY INC | 6,500,000 | $14.1B | 251.29% | |
| 75 | LONAATHIRA PHARMA INC | 1,859,322 | $14.1B | 250.88% | |
| 76 | SEPNSEPTERNA INC | 433,160 | $12.1B | 215.25% | |
| 77 | IKTINHIBIKASE THERAPEUTICS INC | 5,421,568 | $11.1B | 198.10% | |
| 78 | ADGMADAGIO MED HLDGS INC | 9,876,576 | $10.3B | 183.07% | |
| 79 | OCSOCULIS HOLDING AG | 493,827 | $9.9B | 175.77% | |
| 80 | GOSSGOSSAMER BIO INC | 3,139,669 | $9.7B | 173.47% | |
| 81 | MPLTMAPLIGHT THERAPEUTICS INC | 550,000 | $9.7B | 172.18% | |
| 82 | XENEXENON PHARMACEUTICALS INC | 200,791 | $9.0B | 160.40% | |
| 83 | IRDOPUS GENETICS INC | 4,325,000 | $8.7B | 154.95% | |
| 84 | AVRANTERIS TECHNOLOGIES GLOBAL | 1,675,476 | $8.4B | 149.01% | |
| 85 | KMTSKESTRA MED TECHNOLOGIES LTD | 285,000 | $7.6B | 134.72% | |
| 86 | CAPRCAPRICOR THERAPEUTICS INC | 242,100 | $7.0B | 124.54% | Call |
| 87 | BLLNBILLIONTOONE INC | 72,812 | $6.0B | 106.20% | |
| 88 | BHVNBIOHAVEN LTD | 500,000 | $5.6B | 100.62% | Call |
| 89 | KYMRKYMERA THERAPEUTICS INC | 69,935 | $5.4B | 96.98% | |
| 90 | PEPGPEPGEN INC | 829,870 | $5.4B | 96.29% | |
| 91 | CBIOCRESCENT BIOPHARMA INC. | 453,686 | $5.4B | 95.90% | |
| 92 | TENXTENAX THERAPEUTICS INC | 439,142 | $5.4B | 95.41% | |
| 93 | CRVSCORVUS PHARMACEUTICALS INC | 692,441 | $5.3B | 95.02% | |
| 94 | TECXTECTONIC THERAPEUTIC INC | 250,000 | $5.2B | 92.95% | Call |
| 95 | AQSTAQUESTIVE THERAPEUTICS INC | 747,193 | $4.8B | 86.02% | |
| 96 | TNGXTANGO THERAPEUTICS INC | 513,035 | $4.5B | 81.01% | |
| 97 | KRYSKRYSTAL BIOTECH INC | 17,500 | $4.3B | 76.89% | |
| 98 | COGTCOGENT BIOSCIENCES INC | 121,082 | $4.3B | 76.64% | |
| 99 | OLMAOLEMA PHARMACEUTICALS INC | 165,713 | $4.1B | 73.83% | |
| 100 | SDGRSCHRODINGER INC | 202,400 | $3.6B | 64.49% |
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