Siren, L.L.C. Q1 2025 Filing
Filed May 14, 2025
Portfolio Value
$1.8T
Holdings
116
Report Date
Q1 2025
Filing Type
13F-HR
All Holdings (116 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | SRRKScholar Rock Holding Corp | 9,250,005 | $297.4B | 16.93% | |
| 2 | ONCBeigene Ltd | 498,689 | $135.7B | 7.73% | |
| 3 | KYMRKymera Therapeutics Inc | 3,240,313 | $88.7B | 5.05% | |
| 4 | 2L9Blueprint Medicines Corp | 726,167 | $64.3B | 3.66% | |
| 5 | CRNXCrinetics Pharmaceuticals Inc | 1,688,611 | $56.6B | 3.22% | |
| 6 | APLSApellis Pharmaceuticals Inc | 2,578,396 | $56.4B | 3.21% | |
| 7 | IRONDisc Medicine Inc | 1,071,865 | $53.2B | 3.03% | |
| 8 | SLNOSoleno Therapeutics Inc | 727,337 | $52.0B | 2.96% | |
| 9 | ASNDAscendis Pharma A/S | 287,366 | $44.8B | 2.55% | |
| 10 | MRUSMerus NV | 1,043,467 | $43.9B | 2.50% | |
| 11 | BCAXBicara Therapeutics Inc | 3,267,083 | $42.6B | 2.42% | |
| 12 | CNTACentessa Pharmaceuticals PLC | 2,960,029 | $42.6B | 2.42% | |
| 13 | NAMSNewAmsterdam Pharma Company NV | 1,912,030 | $39.1B | 2.23% | |
| 14 | EWTXEdgewise Therapeutics Inc | 1,696,444 | $37.3B | 2.12% | |
| 15 | ARWRArrowhead Pharmaceuticals Inc | 2,669,880 | $34.0B | 1.94% | |
| 16 | RNAAvidity Biosciences Inc | 1,110,610 | $32.8B | 1.87% | |
| 17 | WVEWAVE Life Sciences Ltd | 3,696,322 | $29.9B | 1.70% | |
| 18 | TBLATaboola.com Ltd | 9,969,495 | $29.4B | 1.67% | |
| 19 | DYNDyne Therapeutics Inc | 2,717,987 | $28.4B | 1.62% | |
| 20 | SLDBSolid Biosciences Inc | 7,415,905 | $27.4B | 1.56% | |
| 21 | XENEXenon Pharmaceuticals Inc | 732,761 | $24.6B | 1.40% | |
| 22 | APGEApogee Therapeutics Inc | 594,994 | $22.2B | 1.27% | |
| 23 | RVMDRevolution Medicines Inc | 563,755 | $19.9B | 1.13% | |
| 24 | TRVITrevi Therapeutics Inc | 2,863,793 | $18.0B | 1.03% | |
| 25 | VERAVera Therapeutics Inc | 747,216 | $17.9B | 1.02% | |
| 26 | PRTAProthena Corporation PLC | 1,283,555 | $15.9B | 0.90% | |
| 27 | BCYCBicycle Therapeutics PLC | 1,812,752 | $15.4B | 0.88% | |
| 28 | STOKStoke Therapeutics Inc | 2,247,347 | $14.9B | 0.85% | |
| 29 | RYTMRhythm Pharmaceuticals Inc | 277,533 | $14.7B | 0.84% | |
| 30 | SMMTSummit Therapeutics Inc | 695,000 | $13.4B | 0.76% | |
| 31 | SEPNSepterna Inc | 2,202,514 | $12.8B | 0.73% | |
| 32 | RCUSArcus Biosciences Inc | 1,612,077 | $12.7B | 0.72% | |
| 33 | IHSIHS Holding Limited | 2,357,520 | $12.3B | 0.70% | |
| 34 | ERASErasca Inc | 8,757,249 | $12.0B | 0.68% | |
| 35 | DNLIDenali Therapeutics Inc | 821,513 | $11.2B | 0.64% | |
| 36 | PCVXVaxcyte Inc | 295,543 | $11.2B | 0.64% | |
| 37 | AMZNAmazon.com Inc | 56,500 | $10.7B | 0.61% | |
| 38 | MSFTMicrosoft Corp | 28,500 | $10.7B | 0.61% | |
| 39 | RELYRemitly Global Inc | 490,449 | $10.2B | 0.58% | |
| 40 | TSHATaysha Gene Therapies Inc | 6,514,737 | $9.1B | 0.52% | |
| 41 | CGEMCullinan Therapeutics Inc | 1,193,410 | $9.0B | 0.51% | |
| 42 | CRWDCrowdStrike Holdings Inc | 25,000 | $8.8B | 0.50% | |
| 43 | SLNSilence Therapeutics PLC | 2,789,833 | $7.9B | 0.45% | |
| 44 | GOOGLAlphabet Inc | 50,703 | $7.8B | 0.45% | |
| 45 | RNACCartesian Therapeutics Inc | 563,272 | $7.4B | 0.42% | |
| 46 | ADBEAdobe Inc | 19,298 | $7.4B | 0.42% | |
| 47 | KRROKorro Bio Inc | 418,833 | $7.3B | 0.42% | |
| 48 | NOWServiceNow Inc | 9,126 | $7.3B | 0.41% | |
| 49 | SEERSeer Inc | 4,000,000 | $6.8B | 0.38% | |
| 50 | PDDPDD Holdings Inc | 52,901 | $6.3B | 0.36% | |
| 51 | SYRESpyre Therapeutics Inc | 368,598 | $5.9B | 0.34% | |
| 52 | GOSSGossamer Bio Inc | 5,208,968 | $5.7B | 0.33% | |
| 53 | ORICOric Pharmaceuticals Inc | 1,007,575 | $5.6B | 0.32% | |
| 54 | UPBUpstream Bio Inc | 788,450 | $4.8B | 0.27% | |
| 55 | NVDANVIDIA Corp | 44,432 | $4.8B | 0.27% | |
| 56 | TSMTaiwan Semiconductor Manufacturing Co Ltd | 28,500 | $4.7B | 0.27% | |
| 57 | DDOGDatadog Inc | 47,425 | $4.7B | 0.27% | |
| 58 | NMRANeumora Therapeutics Inc | 4,358,283 | $4.4B | 0.25% | |
| 59 | FROGJfrog Ltd | 131,616 | $4.2B | 0.24% | |
| 60 | DTDynatrace Inc | 87,729 | $4.1B | 0.24% | |
| 61 | MTSRMetsera Inc | 150,000 | $4.1B | 0.23% | |
| 62 | RCKTRocket Pharmaceuticals Inc | 591,263 | $3.9B | 0.22% | |
| 63 | CRMSalesforce Inc | 14,600 | $3.9B | 0.22% | |
| 64 | N1UANew Oriental Education & Technology Group Inc | 79,500 | $3.8B | 0.22% | |
| 65 | RAPPRapport Therapeutics Inc | 378,469 | $3.8B | 0.22% | |
| 66 | IONQIONQ Inc | 170,000 | $3.8B | 0.21% | |
| 67 | 1K0IGM Biosciences Inc | 3,255,826 | $3.7B | 0.21% | |
| 68 | WHWKWhitehawk Therapeutics Inc | 2,082,000 | $3.7B | 0.21% | |
| 69 | TILInstil Bio Inc | 203,933 | $3.5B | 0.20% | |
| 70 | TNGXTango Therapeutics Inc | 2,565,342 | $3.5B | 0.20% | |
| 71 | VIGLVigil Neuroscience Inc | 1,967,064 | $3.5B | 0.20% | |
| 72 | SIONSionna Therapeutics Inc | 325,000 | $3.4B | 0.19% | |
| 73 | NBISNebius Group NV | 140,000 | $3.0B | 0.17% | |
| 74 | FHTXFoghorn Therapeutics Inc. | 720,720 | $2.6B | 0.15% | |
| 75 | RDDTReddit Inc | 23,500 | $2.5B | 0.14% | |
| 76 | LPLALPL Financial Holdings Inc | 7,500 | $2.5B | 0.14% | |
| 77 | SGMTSagimet Biosciences Inc | 724,771 | $2.4B | 0.13% | |
| 78 | ELDNEledon Pharmaceuticals Inc | 690,170 | $2.3B | 0.13% | |
| 79 | TSLATesla Inc | 9,000 | $2.3B | 0.13% | |
| 80 | KLRSKalaris Therapeutics Inc | 282,586 | $2.3B | 0.13% | |
| 81 | MRVLMarvell Technology Inc | 36,808 | $2.3B | 0.13% | |
| 82 | QCOMQualcomm Inc | 14,000 | $2.2B | 0.12% | |
| 83 | BEKEKe Holdings Inc | 105,000 | $2.1B | 0.12% | |
| 84 | LXEOLexeo Therapeutics Inc | 603,435 | $2.1B | 0.12% | |
| 85 | PRQRProQR Therapeutics NV | 1,552,183 | $2.1B | 0.12% | |
| 86 | PANWPalo Alto Networks Inc | 11,500 | $2.0B | 0.11% | |
| 87 | SAILSailPoint Inc | 95,000 | $1.8B | 0.10% | |
| 88 | BDTXBlack Diamond Therapeutics Inc | 1,046,517 | $1.6B | 0.09% | |
| 89 | LXRXLexicon Pharmaceuticals Inc | 3,516,214 | $1.6B | 0.09% | |
| 90 | SAROStandardAero, Inc. | 56,855 | $1.5B | 0.09% | |
| 91 | BIOABIOAGE Labs Inc | 382,406 | $1.4B | 0.08% | |
| 92 | TRMLTourmaline Bio Inc | 91,426 | $1.4B | 0.08% | |
| 93 | WKWorkiva Inc | 17,500 | $1.3B | 0.08% | |
| 94 | BILLBILL Holdings Inc | 28,500 | $1.3B | 0.07% | |
| 95 | PYPLPayPal Holdings Inc | 20,000 | $1.3B | 0.07% | |
| 96 | GBIOGBXGeneration Bio Co | 2,968,925 | $1.2B | 0.07% | |
| 97 | SEMRSEMrush Holdings Inc | 125,000 | $1.2B | 0.07% | |
| 98 | PEGAPegasystems Inc | 16,500 | $1.1B | 0.07% | |
| 99 | MDBMongoDB Inc | 5,500 | $964.7M | 0.05% | |
| 100 | NKENike Inc | 15,000 | $952.2M | 0.05% |
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