SPHERA FUNDS MANAGEMENT LTD. Q2 2025 Filing
Filed August 14, 2025
Portfolio Value
$426.1M
Holdings
104
Report Date
Q2 2025
Filing Type
13F-HR
All Holdings (104 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | TEVATEVA PHARMACEUTICAL INDS LTD | 1,620,990 | $27.2M | 6.38% | |
| 2 | NVMINOVA LTD | 75,836 | $20.9M | 4.90% | |
| 3 | XBISPDR SERIES TRUST | 200,000 | $16.6M | 3.89% | Put |
| 4 | SNDXSYNDAX PHARMACEUTICALS INC | 1,571,564 | $14.7M | 3.45% | |
| 5 | TSEMTOWER SEMICONDUCTOR LTD | 264,722 | $11.5M | 2.69% | |
| 6 | CYTKCYTOKINETICS INC | 326,718 | $10.8M | 2.53% | |
| 7 | SNYSANOFI | 219,515 | $10.6M | 2.49% | |
| 8 | BIIBBIOGEN INC | 82,738 | $10.4M | 2.44% | |
| 9 | RAREULTRAGENYX PHARMACEUTICAL IN | 280,685 | $10.2M | 2.39% | Call |
| 10 | AZNASTRAZENECA PLC | 135,060 | $9.4M | 2.21% | |
| 11 | LLYELI LILLY & CO | 11,540 | $9.0M | 2.11% | |
| 12 | PRAXPRAXIS PRECISION MEDICINES I | 209,757 | $8.8M | 2.07% | Call |
| 13 | NVDANVIDIA CORPORATION | 54,515 | $8.6M | 2.02% | |
| 14 | TCE2CELLDEX THERAPEUTICS INC NEW | 419,540 | $8.5M | 2.00% | |
| 15 | NVONOVO-NORDISK A S | 105,677 | $7.3M | 1.71% | |
| 16 | AMZNAMAZON COM INC | 32,441 | $7.1M | 1.67% | |
| 17 | CDTXCIDARA THERAPEUTICS INC | 138,001 | $6.7M | 1.58% | |
| 18 | HNMORMAT TECHNOLOGIES INC | 78,000 | $6.5M | 1.53% | |
| 19 | MLYSMINERALYS THERAPEUTICS INC | 480,974 | $6.5M | 1.53% | |
| 20 | FBRXFORTE BIOSCIENCES INC | 495,109 | $6.4M | 1.50% | |
| 21 | METAMETA PLATFORMS INC | 8,526 | $6.3M | 1.48% | |
| 22 | JNJJOHNSON & JOHNSON | 40,831 | $6.2M | 1.46% | |
| 23 | BBIOBRIDGEBIO PHARMA INC | 137,008 | $5.9M | 1.39% | Put |
| 24 | MLTXMOONLAKE IMMUNOTHERAPEUTICS | 125,000 | $5.9M | 1.38% | Call |
| 25 | MSFTMICROSOFT CORP | 11,792 | $5.9M | 1.38% | |
| 26 | AM6AMICUS THERAPEUTICS INC | 990,718 | $5.7M | 1.33% | |
| 27 | ORA 2.5 07/15/27 SEPTORMAT TECHNOLOGIES INC | 5,037,000 | $5.6M | 1.32% | |
| 28 | PHVSPHARVARIS N V | 309,931 | $5.5M | 1.28% | |
| 29 | ELDNELEDON PHARMACEUTICALS INC | 1,990,810 | $5.4M | 1.27% | Call |
| 30 | SRPTSAREPTA THERAPEUTICS INC | 309,323 | $5.3M | 1.24% | Call |
| 31 | TVTXTRAVERE THERAPEUTICS INC | 335,333 | $5.0M | 1.16% | |
| 32 | ABBVABBVIE INC | 25,256 | $4.7M | 1.10% | |
| 33 | GSKGSK PLC | 122,000 | $4.7M | 1.10% | |
| 34 | NVSNNOVARTIS AG | 37,000 | $4.5M | 1.05% | |
| 35 | TRVITREVI THERAPEUTICS INC | 799,957 | $4.4M | 1.03% | |
| 36 | MAZEMAZE THERAPEUTICS INC | 356,453 | $4.4M | 1.03% | |
| 37 | ANNXANNEXON INC | 1,764,387 | $4.2M | 0.99% | |
| 38 | TLTISHARES TR | 47,000 | $4.1M | 0.97% | Call |
| 39 | IMVTIMMUNOVANT INC | 256,743 | $4.1M | 0.96% | |
| 40 | ORICORIC PHARMACEUTICALS INC | 394,693 | $4.0M | 0.94% | |
| 41 | MRKMERCK & CO INC | 48,600 | $3.8M | 0.90% | |
| 42 | ACADACADIA PHARMACEUTICALS INC | 174,900 | $3.8M | 0.89% | |
| 43 | RNAAVIDITY BIOSCIENCES INC | 126,000 | $3.6M | 0.84% | |
| 44 | ACOGALPHA COGNITION INC | 376,649 | $3.5M | 0.82% | |
| 45 | RZLTREZOLUTE INC | 751,447 | $3.4M | 0.79% | |
| 46 | HELPCYBIN INC | 398,309 | $3.3M | 0.78% | |
| 47 | AMATAPPLIED MATLS INC | 18,000 | $3.3M | 0.77% | |
| 48 | ARWRARROWHEAD PHARMACEUTICALS IN | 202,996 | $3.2M | 0.75% | |
| 49 | IMTXIMMATICS N.V | 583,105 | $3.1M | 0.74% | |
| 50 | YB4PSAVARA INC | 1,310,233 | $3.0M | 0.70% | |
| 51 | UBERUBER TECHNOLOGIES INC | 30,000 | $2.8M | 0.66% | |
| 52 | CAMTCAMTEK LTD | 31,976 | $2.7M | 0.63% | |
| 53 | ESLTELBIT SYS LTD | 6,000 | $2.7M | 0.63% | |
| 54 | PANWPALO ALTO NETWORKS INC | 13,114 | $2.7M | 0.63% | |
| 55 | WIXWIX COM LTD | 16,931 | $2.7M | 0.63% | |
| 56 | AMGNAMGEN INC | 9,500 | $2.7M | 0.62% | |
| 57 | SEDGSOLAREDGE TECHNOLOGIES INC | 127,966 | $2.6M | 0.61% | |
| 58 | ELVNENLIVEN THERAPEUTICS INC | 128,515 | $2.6M | 0.60% | |
| 59 | COGTCOGENT BIOSCIENCES INC | 343,693 | $2.5M | 0.58% | Call |
| 60 | SKYESKYE BIOSCIENCE INC | 538,434 | $2.3M | 0.53% | |
| 61 | DYNDYNE THERAPEUTICS INC | 221,416 | $2.1M | 0.49% | |
| 62 | PFEPFIZER INC | 86,000 | $2.1M | 0.49% | |
| 63 | BHVNBIOHAVEN LTD | 145,372 | $2.1M | 0.48% | |
| 64 | SRRKSCHOLAR ROCK HLDG CORP | 57,497 | $2.0M | 0.48% | |
| 65 | ETNBGBP89BIO INC | 205,675 | $2.0M | 0.47% | |
| 66 | GPCRSTRUCTURE THERAPEUTICS INC | 95,931 | $2.0M | 0.47% | |
| 67 | JANXJANUX THERAPEUTICS INC | 85,840 | $2.0M | 0.47% | |
| 68 | APLSAPELLIS PHARMACEUTICALS INC | 114,346 | $2.0M | 0.46% | |
| 69 | CRMSALESFORCE INC | 6,800 | $1.9M | 0.44% | |
| 70 | ENGNENGENE HOLDINGS INC | 504,409 | $1.8M | 0.43% | |
| 71 | CYBRCYBERARK SOFTWARE LTD | 4,000 | $1.6M | 0.38% | |
| 72 | MRVLMARVELL TECHNOLOGY INC | 18,730 | $1.4M | 0.34% | |
| 73 | CATBUSDASTRIA THERAPEUTICS INC | 257,402 | $1.4M | 0.32% | |
| 74 | KURAKURA ONCOLOGY INC | 235,522 | $1.4M | 0.32% | |
| 75 | IBITISHARES BITCOIN TRUST ETF | 21,455 | $1.3M | 0.31% | |
| 76 | NTLAINTELLIA THERAPEUTICS INC | 128,780 | $1.2M | 0.28% | |
| 77 | VTYXVENTYX BIOSCIENCES INC | 555,814 | $1.2M | 0.28% | |
| 78 | AMDADVANCED MICRO DEVICES INC | 8,250 | $1.2M | 0.27% | |
| 79 | NNDMNANO DIMENSION LTD | 717,518 | $1.2M | 0.27% | |
| 80 | DAWNDAY ONE BIOPHARMACEUTICALS I | 175,371 | $1.1M | 0.27% | |
| 81 | CEVACEVA INC | 48,920 | $1.1M | 0.25% | |
| 82 | CATXPERSPECTIVE THERAPEUTICS INC | 310,343 | $1.1M | 0.25% | |
| 83 | KRYSKRYSTAL BIOTECH INC | 7,335 | $1.0M | 0.24% | |
| 84 | TSHATAYSHA GENE THERAPIES INC | 420,000 | $970K | 0.23% | |
| 85 | PMNEURPROMIS NEUROSCIENCES INC | 1,899,297 | $918K | 0.22% | |
| 86 | VTGNVISTAGEN THERAPEUTICS INC | 447,939 | $895K | 0.21% | |
| 87 | CMMBCHEMOMAB THERAPEUTICS LTD | 738,048 | $856K | 0.20% | |
| 88 | BMYBRISTOL-MYERS SQUIBB CO | 17,500 | $810K | 0.19% | |
| 89 | CRVSCORVUS PHARMACEUTICALS INC | 183,094 | $732K | 0.17% | |
| 90 | HOWLWEREWOLF THERAPEUTICS INC | 626,810 | $683K | 0.16% | |
| 91 | VSTMVERASTEM INC | 163,307 | $677K | 0.16% | |
| 92 | BCAXBICARA THERAPEUTICS INC | 65,679 | $610K | 0.14% | |
| 93 | LRMRLARIMAR THERAPEUTICS INC | 196,635 | $568K | 0.13% | |
| 94 | SSENTINELONE INC | 27,000 | $493K | 0.12% | |
| 95 | APREAPREA THERAPEUTICS INC | 270,000 | $456K | 0.11% | |
| 96 | CGNTCOGNYTE SOFTWARE LTD | 45,181 | $417K | 0.10% | |
| 97 | KZRKEZAR LIFE SCIENCES INC | 58,539 | $268K | 0.06% | |
| 98 | CLYMCLIMB BIO INC | 209,837 | $260K | 0.06% | |
| 99 | SLDBSOLID BIOSCIENCES INC | 50,190 | $244K | 0.06% | |
| 100 | PEPGPEPGEN INC | 156,467 | $173K | 0.04% |
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