Ikarian Capital, LLC Q4 2025 Filing

Filed February 18, 2026

Portfolio Value

$1.3B

Holdings

148

Report Date

Q4 2025

Filing Type

13F-HR

All Holdings (148 positions)

#StockSharesValue% PortfolioType
1
CDTXCIDARA THERAPEUTICS INC
573,243$126.6M9.89%Put
2
XBISPDR SERIES TRUST
850,000$103.6M8.09%Put
3
AMGNAMGEN INC
245,000$80.2M6.26%Put
4
TERNTERNS PHARMACEUTICALS INC
1,596,378$64.5M5.04%
5
ABVXABIVAX SA
331,085$46.0M3.59%Call
6
HROWHARROW INC
693,047$34.0M2.65%Call
7
RAPTRAPT THERAPEUTICS INC
955,271$32.4M2.53%Call
8
CYTKCYTOKINETICS INC
463,572$29.5M2.30%Call
9
JAZZJAZZ PHARMACEUTICALS PLC
170,000$28.9M2.26%Call
10
SLNOSOLENO THERAPEUTICS INC
597,723$27.7M2.16%Call
11
JAZZJAZZ PHARMACEUTICALS PLC
160,367$27.3M2.13%
12
MAZEMAZE THERAPEUTICS INC
644,680$26.7M2.09%
13
OMEROMEROS CORP
1,500,000$25.8M2.01%Put
14
PRAXPRAXIS PRECISION MEDICINES I
86,581$25.5M1.99%
15
OLMAOLEMA PHARMACEUTICALS INC
958,654$24.0M1.87%Call
16
ISIIONIS PHARMACEUTICALS INC
296,638$23.5M1.83%Call
17
HTDCORCEPT THERAPEUTICS INC
586,093$20.4M1.59%Put
18
KODKODIAK SCIENCES INC
719,787$20.1M1.57%
19
RVMDREVOLUTION MEDICINES INC
233,142$18.6M1.45%Call
20
PCVXVAXCYTE INC
378,682$17.5M1.36%
21
CRNXCRINETICS PHARMACEUTICALS IN
368,500$17.2M1.34%Put
22
CAPRCAPRICOR THERAPEUTICS INC
578,015$16.7M1.30%
23
FULCFULCRUM THERAPEUTICS INC
1,375,472$15.6M1.21%
24
NBIXNEUROCRINE BIOSCIENCES INC
105,062$14.9M1.16%Call
25
LLYELI LILLY & CO
13,815$14.8M1.16%
26
RLMDRELMADA THERAPEUTICS INC
3,068,359$14.8M1.16%
27
CNTBCONNECT BIOPHARMA HLDGS LTD
4,933,086$13.9M1.09%Call
28
CTMXCYTOMX THERAPEUTICS INC
3,172,616$13.5M1.06%
29
PHVSPHARVARIS N V
486,856$13.5M1.05%
30
DRUGBRIGHT MINDS BIOSCIENCES INC
159,421$12.4M0.97%
31
RAREULTRAGENYX PHARMACEUTICAL IN
517,771$11.9M0.93%Put
32
TENXTENAX THERAPEUTICS INC
967,600$11.8M0.92%
33
SPRBSPRUCE BIOSCIENCES INC
121,356$10.6M0.83%
34
CELCCELCUITY INC
105,545$10.5M0.82%
35
APLSAPELLIS PHARMACEUTICALS INC
397,347$10.0M0.78%Call
36
ANROALTO NEUROSCIENCE INC
515,000$9.2M0.72%
37
DC4DEXCOM INC
137,500$9.1M0.71%Call
38
PTCTPTC THERAPEUTICS INC
118,657$9.0M0.70%
39
VTYXVENTYX BIOSCIENCES INC
958,704$8.7M0.68%
40
CGONCG ONCOLOGY INC
199,473$8.3M0.65%
41
FBRXFORTE BIOSCIENCES INC
300,000$8.2M0.64%
42
PTHSPELTHOS THERAPEUTICS INC
255,758$7.9M0.62%
43
MLYSMINERALYS THERAPEUTICS INC
200,000$7.3M0.57%
44
AGIOAGIOS PHARMACEUTICALS INC
252,689$6.9M0.54%Call
45
ACOGALPHA COGNITION INC
1,056,259$6.9M0.54%
46
GLTOGALECTO INC
285,710$6.6M0.51%
47
IVVDINVIVYD INC
2,656,570$6.6M0.51%
48
BSFAANI PHARMACEUTICALS INC
82,800$6.5M0.51%Call
49
NUVLNUVALENT INC
59,594$6.0M0.47%
50
LXEOLEXEO THERAPEUTICS INC
513,011$5.1M0.40%
51
LEGNLEGEND BIOTECH CORP
226,888$4.9M0.39%
52
PEPGPEPGEN INC
747,165$4.9M0.38%Call
53
JBIOJADE BIOSCIENCES INC
300,000$4.6M0.36%
54
EPRXEUPRAXIA PHARMACEUTICALS INC
610,000$4.6M0.36%
55
DCTHDELCATH SYS INC
431,251$4.4M0.34%
56
CMPXCOMPASS THERAPEUTICS INC
800,000$4.3M0.34%
57
ADMAADMA BIOLOGICS INC
234,854$4.3M0.33%
58
ARVNARVINAS INC
358,257$4.2M0.33%
59
ZURAZURA BIO LTD
802,322$4.2M0.33%
60
KPTIKARYOPHARM THERAPEUTICS INC
544,554$4.0M0.31%
61
KRYSKRYSTAL BIOTECH INC
14,814$3.7M0.29%
62
TGTXTG THERAPEUTICS INC
117,903$3.5M0.27%
63
VIRVIR BIOTECHNOLOGY INC
575,712$3.5M0.27%
64
ZBIOZENAS BIOPHARMA INC
93,600$3.4M0.27%Put
65
NXTCNEXTCURE INC
238,303$3.4M0.26%
66
SLDBSOLID BIOSCIENCES INC
584,409$3.3M0.26%Call
67
ALECALECTOR INC
2,082,606$3.2M0.25%
68
CTNMCONTINEUM THERAPEUTICS INC
282,874$3.2M0.25%
69
AQSTAQUESTIVE THERAPEUTICS INC
500,000$3.2M0.25%Put
70
PERCEPTIVE CAP SOLUTIONS COR
240,951$3.1M0.25%
71
IM8NINSMED INC
17,937$3.1M0.24%Call
72
GOSSGOSSAMER BIO INC
1,000,000$3.1M0.24%Put
73
NKTRNEKTAR THERAPEUTICS
72,600$3.1M0.24%Put
74
QNRXQUOIN PHARMACEUTICALS LTD
211,538$3.1M0.24%
75
KLRSKALARIS THERAPEUTICS INC
360,000$3.0M0.24%
76
PRQRPROQR THRAPEUTICS N V
1,492,229$3.0M0.24%
77
CMPSCOMPASS PATHWAYS PLC
400,000$2.8M0.22%
78
BBOTBRIDGEBIO ONCOLOGY THERAPEUT
220,231$2.8M0.22%
79
ERASERASCA INC
735,396$2.7M0.21%
80
TARSTARSUS PHARMACEUTICALS INC
31,166$2.6M0.20%
81
QUREUNIQURE NV
105,400$2.5M0.20%Call
82
GUTSFRACTYL HEALTH INC
1,100,000$2.4M0.19%
83
BHVNBIOHAVEN LTD
212,481$2.4M0.19%
84
IVAINVENTIVA SA
502,601$2.3M0.18%
85
NMRANEUMORA THERAPEUTICS INC.
1,278,408$2.3M0.18%
86
CPIXCUMBERLAND PHARMACEUTICALS I
555,932$2.2M0.17%
87
QUREUNIQURE NV
91,060$2.2M0.17%
88
DBVTDBV TECHNOLOGIES S A
525,000$2.1M0.16%
89
ALMSALUMIS INC
211,100$2.1M0.16%Put
90
CABACABALETTA BIO INC
900,000$2.0M0.15%
91
DERMJOURNEY MED CORP
251,436$1.9M0.15%
92
IBIOIBIO INC
957,062$1.8M0.14%
93
SLNSILENCE THERAPEUTICS PLC
865,784$1.7M0.14%
94
VSTMVERASTEM INC
213,865$1.7M0.13%
95
AVTXAVALO THERAPEUTICS INC
89,206$1.6M0.13%Call
96
NAMSNEWAMSTERDAM PHARMA COMPANY
45,830$1.6M0.13%
97
LPCNLIPOCINE INC NEW
199,542$1.6M0.13%
98
SRZNSURROZEN INC
65,788$1.5M0.12%
99
WVEWAVE LIFE SCIENCES LTD
85,285$1.4M0.11%
100
TVTXTRAVERE THERAPEUTICS INC
36,600$1.4M0.11%Call
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