Siren, L.L.C. Q3 2025 Filing
Filed November 13, 2025
Portfolio Value
$2.6T
Holdings
115
Report Date
Q3 2025
Filing Type
13F-HR
All Holdings (115 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | SRRKScholar Rock Holding Corp | 9,250,005 | $344.5B | 13.48% | |
| 2 | KYMRKymera Therapeutics Inc | 3,428,150 | $194.0B | 7.59% | |
| 3 | ONCBeOne Medicines AG | 492,990 | $168.0B | 6.57% | |
| 4 | ARWRArrowhead Pharmaceuticals Inc | 2,669,880 | $92.1B | 3.60% | |
| 5 | BCAXBicara Therapeutics Inc | 5,216,969 | $82.4B | 3.22% | |
| 6 | CNTACentessa Pharmaceuticals PLC | 3,227,517 | $78.3B | 3.06% | |
| 7 | CRNXCrinetics Pharmaceuticals Inc | 1,688,611 | $70.3B | 2.75% | |
| 8 | EWTXEdgewise Therapeutics Inc | 3,897,099 | $63.2B | 2.47% | |
| 9 | IRONDisc Medicine Inc | 913,401 | $60.4B | 2.36% | |
| 10 | DYNDyne Therapeutics Inc | 4,729,174 | $59.8B | 2.34% | |
| 11 | APLSApellis Pharmaceuticals Inc | 2,578,396 | $58.3B | 2.28% | |
| 12 | RNAAvidity Biosciences Inc | 1,285,610 | $56.0B | 2.19% | |
| 13 | STOKStoke Therapeutics Inc | 2,247,347 | $52.8B | 2.07% | |
| 14 | LXRXLexicon Pharmaceuticals Inc | 38,918,903 | $52.5B | 2.06% | |
| 15 | RYTMRhythm Pharmaceuticals Inc | 499,975 | $50.5B | 1.98% | |
| 16 | TNGXTango Therapeutics Inc | 5,883,188 | $49.4B | 1.93% | |
| 17 | RVMDRevolution Medicines Inc | 1,043,720 | $48.7B | 1.91% | |
| 18 | ASNDAscendis Pharma A/S | 235,862 | $46.9B | 1.83% | |
| 19 | RZLTRezolute Inc | 4,870,000 | $45.8B | 1.79% | |
| 20 | SLDBSolid Biosciences Inc | 7,415,905 | $45.8B | 1.79% | |
| 21 | SEPNSepterna Inc | 2,202,514 | $41.4B | 1.62% | |
| 22 | RCUSArcus Biosciences Inc | 2,912,077 | $39.6B | 1.55% | |
| 23 | TSHATaysha Gene Therapies Inc | 11,014,737 | $36.0B | 1.41% | |
| 24 | TBLATaboola.com Ltd | 9,969,495 | $34.0B | 1.33% | |
| 25 | XENEXenon Pharmaceuticals Inc | 812,761 | $32.6B | 1.28% | |
| 26 | SLNOSoleno Therapeutics Inc | 467,342 | $31.6B | 1.24% | |
| 27 | RAPPRapport Therapeutics Inc | 1,053,469 | $31.3B | 1.22% | |
| 28 | GPCRStructure Therapeutics Inc | 1,026,811 | $28.8B | 1.12% | |
| 29 | WVEWAVE Life Sciences Ltd | 3,696,322 | $27.1B | 1.06% | |
| 30 | RELYRemitly Global Inc | 1,618,271 | $26.4B | 1.03% | |
| 31 | COGTCogent Biosciences Inc | 1,724,279 | $24.8B | 0.97% | |
| 32 | TRVITrevi Therapeutics Inc | 2,536,867 | $23.2B | 0.91% | |
| 33 | NAMSNewAmsterdam Pharma Company NV | 765,705 | $21.8B | 0.85% | |
| 34 | KRROKorro Bio Inc | 418,833 | $20.1B | 0.78% | |
| 35 | ERASErasca Inc | 8,757,249 | $19.1B | 0.75% | |
| 36 | IHSIHS Holding Limited | 2,357,520 | $16.1B | 0.63% | |
| 37 | QUREUniqure NV | 275,200 | $16.1B | 0.63% | |
| 38 | BCYCBicycle Therapeutics PLC | 2,012,752 | $15.6B | 0.61% | |
| 39 | SLNSilence Therapeutics PLC | 2,911,438 | $15.1B | 0.59% | |
| 40 | RAPTRAPT Therapeutics Inc | 580,466 | $15.0B | 0.59% | |
| 41 | UPBUpstream Bio Inc | 788,450 | $14.8B | 0.58% | |
| 42 | GOSSGossamer Bio Inc | 5,208,968 | $13.7B | 0.54% | |
| 43 | AVBPArrivent Biopharma Inc | 700,000 | $12.9B | 0.51% | |
| 44 | AMZNAmazon.com Inc | 58,500 | $12.8B | 0.50% | |
| 45 | ORICOric Pharmaceuticals Inc | 1,007,575 | $12.1B | 0.47% | |
| 46 | DNLIDenali Therapeutics Inc | 821,513 | $11.9B | 0.47% | |
| 47 | IONQIONQ Inc | 170,000 | $10.5B | 0.41% | |
| 48 | SIONSionna Therapeutics Inc | 325,000 | $9.6B | 0.37% | |
| 49 | CRWDCrowdStrike Holdings Inc | 18,500 | $9.1B | 0.35% | |
| 50 | MSFTMicrosoft Corp | 17,150 | $8.9B | 0.35% | |
| 51 | SEERSeer Inc | 4,000,000 | $8.7B | 0.34% | |
| 52 | NBISNebius Group NV | 72,600 | $8.2B | 0.32% | |
| 53 | NMRANeumora Therapeutics Inc | 4,358,283 | $7.9B | 0.31% | |
| 54 | TSMTaiwan Semiconductor Manufacturing Co Ltd | 28,200 | $7.9B | 0.31% | |
| 55 | CRMSalesforce Inc | 30,100 | $7.1B | 0.28% | |
| 56 | CGEMCullinan Therapeutics Inc | 1,193,410 | $7.1B | 0.28% | |
| 57 | NVDANVIDIA Corp | 37,485 | $7.0B | 0.27% | |
| 58 | NOWServiceNow Inc | 7,126 | $6.6B | 0.26% | |
| 59 | SYRESpyre Therapeutics Inc | 368,598 | $6.2B | 0.24% | |
| 60 | RNACCartesian Therapeutics Inc | 563,272 | $5.8B | 0.23% | |
| 61 | PDDPDD Holdings Inc | 43,401 | $5.7B | 0.22% | |
| 62 | ELDNEledon Pharmaceuticals Inc | 2,072,767 | $5.4B | 0.21% | |
| 63 | ADBEAdobe Inc | 15,051 | $5.3B | 0.21% | |
| 64 | GOOGLAlphabet Inc | 21,203 | $5.2B | 0.20% | |
| 65 | FROGJfrog Ltd | 107,116 | $5.1B | 0.20% | |
| 66 | SGMTSagimet Biosciences Inc | 724,771 | $5.0B | 0.19% | |
| 67 | DTDynatrace Inc | 100,229 | $4.9B | 0.19% | |
| 68 | DDOGDatadog Inc | 32,925 | $4.7B | 0.18% | |
| 69 | NBPI-Mab | 1,165,957 | $4.4B | 0.17% | |
| 70 | AGENAgenus Inc | 1,064,250 | $4.1B | 0.16% | |
| 71 | LXEOLexeo Therapeutics Inc | 603,435 | $4.0B | 0.16% | |
| 72 | BDTXBlack Diamond Therapeutics Inc | 1,046,517 | $4.0B | 0.16% | |
| 73 | WHWKWhitehawk Therapeutics Inc | 2,082,000 | $4.0B | 0.15% | |
| 74 | VTVTvTv Therapeutics Inc | 163,000 | $3.8B | 0.15% | |
| 75 | TILInstil Bio Inc | 203,933 | $3.6B | 0.14% | |
| 76 | FHTXFoghorn Therapeutics Inc | 720,720 | $3.5B | 0.14% | |
| 77 | PRQRProQR Therapeutics NV | 1,552,183 | $3.3B | 0.13% | |
| 78 | N1UANew Oriental Education & Technology Group Inc | 62,000 | $3.3B | 0.13% | |
| 79 | CRWVCoreWeave Inc | 24,000 | $3.3B | 0.13% | |
| 80 | PEPGPepGen Inc | 700,000 | $3.2B | 0.13% | |
| 81 | GTLBGitLab Inc | 64,000 | $2.9B | 0.11% | |
| 82 | BEKEKe Holdings Inc | 145,000 | $2.8B | 0.11% | |
| 83 | PANWPalo Alto Networks Inc | 13,450 | $2.7B | 0.11% | |
| 84 | TENXTenax Therapeutics Inc | 352,441 | $2.7B | 0.10% | |
| 85 | WKWorkiva Inc | 30,000 | $2.6B | 0.10% | |
| 86 | QCOMQualcomm Inc | 14,000 | $2.3B | 0.09% | |
| 87 | BIOABIOAGE Labs Inc | 382,406 | $2.2B | 0.09% | |
| 88 | KDPKeurig Dr Pepper Inc | 77,050 | $2.0B | 0.08% | |
| 89 | HUBSHubSpot Inc | 4,000 | $1.9B | 0.07% | |
| 90 | CMGChipotle Mexican Grill Inc | 47,500 | $1.9B | 0.07% | |
| 91 | KLRSKalaris Therapeutics Inc | 318,264 | $1.8B | 0.07% | |
| 92 | GBIOGeneration Bio Co | 296,892 | $1.8B | 0.07% | |
| 93 | CLBTCellebrite DI Ltd | 90,000 | $1.7B | 0.07% | |
| 94 | PRMBPrimo Brands Corp | 75,000 | $1.7B | 0.06% | |
| 95 | SPOTSpotify Technology SA | 2,173 | $1.5B | 0.06% | |
| 96 | NIQNIQ Global Intelligence PLC | 95,000 | $1.5B | 0.06% | |
| 97 | MNDYmonday.com Ltd | 7,000 | $1.4B | 0.05% | |
| 98 | SAILSailPoint Inc | 50,000 | $1.1B | 0.04% | |
| 99 | ESTCElastic NV | 12,500 | $1.1B | 0.04% | |
| 100 | IRENIREN Ltd | 20,000 | $938.1M | 0.04% |
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