SPHERA FUNDS MANAGEMENT LTD. Q3 2025 Filing
Filed November 14, 2025
Portfolio Value
$474.1B
Holdings
105
Report Date
Q3 2025
Filing Type
13F-HR
All Holdings (105 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | TEVATEVA PHARMACEUTICAL INDS LTD | 1,507,025 | $30.4B | 6.42% | |
| 2 | NSYNICE LTD | 157,400 | $22.8B | 4.81% | |
| 3 | TSEMTOWER SEMICONDUCTOR LTD | 311,802 | $22.5B | 4.76% | |
| 4 | CDTXCIDARA THERAPEUTICS INC | 175,743 | $16.8B | 3.55% | Call |
| 5 | MRUSMERUS N V | 150,000 | $14.1B | 2.98% | Call |
| 6 | NVMINOVA LTD | 43,896 | $14.0B | 2.96% | |
| 7 | NDQINVESCO QQQ TR | 22,960 | $13.8B | 2.91% | |
| 8 | BIIBBIOGEN INC | 82,738 | $11.6B | 2.44% | |
| 9 | RAREULTRAGENYX PHARMACEUTICAL IN | 352,558 | $10.6B | 2.24% | |
| 10 | AZNASTRAZENECA PLC | 135,060 | $10.4B | 2.19% | |
| 11 | SNYSANOFI SA | 219,515 | $10.4B | 2.19% | |
| 12 | CYTKCYTOKINETICS INC | 161,517 | $8.9B | 1.87% | |
| 13 | BBIOBRIDGEBIO PHARMA INC | 170,746 | $8.9B | 1.87% | Call |
| 14 | MLYSMINERALYS THERAPEUTICS INC | 219,910 | $8.3B | 1.76% | |
| 15 | AM6AMICUS THERAPEUTICS INC | 991,142 | $7.8B | 1.65% | |
| 16 | LLYELI LILLY & CO | 10,040 | $7.7B | 1.62% | |
| 17 | JNJJOHNSON & JOHNSON | 40,831 | $7.6B | 1.60% | |
| 18 | FBRXFORTE BIOSCIENCES INC | 474,309 | $7.1B | 1.50% | |
| 19 | TRVITREVI THERAPEUTICS INC | 773,157 | $7.1B | 1.49% | Call |
| 20 | GPCRSTRUCTURE THERAPEUTICS INC | 223,931 | $6.3B | 1.32% | Call |
| 21 | SNDXSYNDAX PHARMACEUTICALS INC | 387,716 | $6.0B | 1.26% | |
| 22 | NVONOVO-NORDISK A S | 105,677 | $5.9B | 1.24% | |
| 23 | ABBVABBVIE INC | 25,256 | $5.8B | 1.23% | |
| 24 | QUREUNIQURE NV | 99,900 | $5.8B | 1.23% | Put |
| 25 | PRAXPRAXIS PRECISION MEDICINES I | 107,901 | $5.7B | 1.21% | Call |
| 26 | CLBTCELLEBRITE DI LTD | 298,948 | $5.5B | 1.17% | |
| 27 | ANNXANNEXON INC | 1,794,387 | $5.5B | 1.15% | |
| 28 | DYNDYNE THERAPEUTICS INC | 426,518 | $5.4B | 1.14% | |
| 29 | TCE2CELLDEX THERAPEUTICS INC NEW | 207,764 | $5.4B | 1.13% | |
| 30 | SEDG 2.25 07/01/29SOLAREDGE TECHNOLOGIES INC | 4,000,000 | $5.3B | 1.12% | |
| 31 | GSKGSK PLC | 122,000 | $5.3B | 1.11% | |
| 32 | SEDGSOLAREDGE TECHNOLOGIES INC | 140,966 | $5.2B | 1.10% | |
| 33 | ORICORIC PHARMACEUTICALS INC | 431,693 | $5.2B | 1.09% | |
| 34 | IMTXIMMATICS N.V | 583,105 | $5.0B | 1.05% | |
| 35 | YB4PSAVARA INC | 1,350,333 | $4.8B | 1.02% | |
| 36 | NVSNNOVARTIS AG | 37,000 | $4.7B | 1.00% | |
| 37 | RAPPRAPPORT THERAPEUTICS INC | 157,533 | $4.7B | 0.99% | |
| 38 | VRNSVARONIS SYS INC | 73,900 | $4.2B | 0.90% | |
| 39 | TLTISHARES TR | 47,000 | $4.2B | 0.89% | Call |
| 40 | IMVTIMMUNOVANT INC | 256,743 | $4.1B | 0.87% | |
| 41 | MRKMERCK & CO INC | 48,600 | $4.1B | 0.86% | |
| 42 | MAZEMAZE THERAPEUTICS INC | 154,343 | $4.0B | 0.84% | |
| 43 | ELDNELEDON PHARMACEUTICALS INC | 1,480,233 | $3.8B | 0.81% | Put |
| 44 | ENGNENGENE HOLDINGS INC | 504,409 | $3.4B | 0.73% | |
| 45 | ESLTELBIT SYS LTD | 6,740 | $3.4B | 0.72% | |
| 46 | RZLTREZOLUTE INC | 363,947 | $3.4B | 0.72% | |
| 47 | ELVNENLIVEN THERAPEUTICS INC | 166,765 | $3.4B | 0.72% | |
| 48 | MDWDMEDIWOUND LTD | 185,270 | $3.3B | 0.70% | |
| 49 | ACADACADIA PHARMACEUTICALS INC | 148,900 | $3.2B | 0.67% | |
| 50 | CAMTCAMTEK LTD | 29,048 | $3.1B | 0.64% | |
| 51 | AMZNAMAZON COM INC | 13,760 | $3.0B | 0.64% | |
| 52 | CRVSCORVUS PHARMACEUTICALS INC | 407,709 | $3.0B | 0.63% | |
| 53 | PHVSPHARVARIS N V | 119,406 | $3.0B | 0.63% | |
| 54 | ROIVROIVANT SCIENCES LTD | 194,171 | $2.9B | 0.62% | Call |
| 55 | SRPTSAREPTA THERAPEUTICS INC | 150,000 | $2.9B | 0.61% | Call |
| 56 | METAMETA PLATFORMS INC | 3,924 | $2.9B | 0.61% | |
| 57 | SLNOSOLENO THERAPEUTICS INC | 41,606 | $2.8B | 0.59% | |
| 58 | RVMDREVOLUTION MEDICINES INC | 60,000 | $2.8B | 0.59% | |
| 59 | HNMORMAT TECHNOLOGIES INC | 29,000 | $2.8B | 0.59% | |
| 60 | IDYAIDEAYA BIOSCIENCES INC | 100,000 | $2.7B | 0.57% | |
| 61 | AMGNAMGEN INC | 9,500 | $2.7B | 0.57% | |
| 62 | AMDADVANCED MICRO DEVICES INC | 15,470 | $2.5B | 0.53% | |
| 63 | TVTXTRAVERE THERAPEUTICS INC | 101,800 | $2.4B | 0.51% | Call |
| 64 | ACOGALPHA COGNITION INC | 338,752 | $2.2B | 0.47% | |
| 65 | PFEPFIZER INC | 86,000 | $2.2B | 0.46% | |
| 66 | HELPCYBIN INC | 370,376 | $2.2B | 0.46% | |
| 67 | KURAKURA ONCOLOGY INC | 245,522 | $2.2B | 0.46% | |
| 68 | AVGOBROADCOM INC | 6,555 | $2.2B | 0.46% | |
| 69 | CEVACEVA INC | 81,085 | $2.1B | 0.45% | |
| 70 | JANXJANUX THERAPEUTICS INC | 85,840 | $2.1B | 0.44% | |
| 71 | SKYESKYE BIOSCIENCE INC | 478,928 | $1.9B | 0.40% | |
| 72 | CATBUSDASTRIA THERAPEUTICS INC | 251,225 | $1.8B | 0.39% | |
| 73 | TECXTECTONIC THERAPEUTIC INC | 115,908 | $1.8B | 0.38% | |
| 74 | PCVXVAXCYTE INC | 50,000 | $1.8B | 0.38% | |
| 75 | CATXPERSPECTIVE THERAPEUTICS INC | 510,343 | $1.8B | 0.37% | |
| 76 | IMNMIMMUNOME INC | 147,200 | $1.7B | 0.36% | |
| 77 | MISTMILESTONE PHARMACEUTICALS IN | 820,000 | $1.6B | 0.35% | |
| 78 | JSPRJASPER THERAPEUTICS INC | 629,470 | $1.5B | 0.32% | |
| 79 | APLSAPELLIS PHARMACEUTICALS INC | 63,660 | $1.4B | 0.30% | |
| 80 | COGTCOGENT BIOSCIENCES INC | 98,526 | $1.4B | 0.30% | |
| 81 | IBITISHARES BITCOIN TRUST ETF | 21,455 | $1.4B | 0.29% | |
| 82 | VTYXVENTYX BIOSCIENCES INC | 440,114 | $1.4B | 0.29% | |
| 83 | BHVNBIOHAVEN LTD | 91,155 | $1.4B | 0.29% | |
| 84 | BCAXBICARA THERAPEUTICS INC | 85,747 | $1.4B | 0.29% | |
| 85 | TSHATAYSHA GENE THERAPIES INC | 408,146 | $1.3B | 0.28% | |
| 86 | DAWNDAY ONE BIOPHARMACEUTICALS I | 175,371 | $1.2B | 0.26% | |
| 87 | HOWLWEREWOLF THERAPEUTICS INC | 626,810 | $1.2B | 0.26% | |
| 88 | SABSSAB BIOTHERAPEUTICS INC | 566,395 | $1.1B | 0.24% | |
| 89 | ENPHENPHASE ENERGY INC | 26,700 | $944.9M | 0.20% | |
| 90 | VYGRVOYAGER THERAPEUTICS INC | 199,761 | $932.9M | 0.20% | |
| 91 | CLYMCLIMB BIO INC | 434,837 | $874.0M | 0.18% | |
| 92 | LRMRLARIMAR THERAPEUTICS INC | 260,385 | $841.0M | 0.18% | |
| 93 | PEPGPEPGEN INC | 171,467 | $792.2M | 0.17% | |
| 94 | BMYBRISTOL-MYERS SQUIBB CO | 17,500 | $789.3M | 0.17% | |
| 95 | VSTMVERASTEM INC | 78,307 | $691.5M | 0.15% | |
| 96 | ETNBGBP89BIO INC | 39,675 | $583.2M | 0.12% | |
| 97 | MLTXMOONLAKE IMMUNOTHERAPEUTICS | 81,010 | $580.8M | 0.12% | Call |
| 98 | CMMBCHEMOMAB THERAPEUTICS LTD | 179,425 | $471.9M | 0.10% | |
| 99 | ARWRARROWHEAD PHARMACEUTICALS IN | 12,496 | $431.0M | 0.09% | |
| 100 | APREAPREA THERAPEUTICS INC | 270,000 | $398.3M | 0.08% |
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